 | | DRUG: Hydroxyzine hydrochloride | |
| Entry |
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| Name |
Hydroxyzine hydrochloride (JP18/USP);
Hydroxyzine dihydrochloride;
Atarax (TN);
Vistaril (TN) |
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| Product |
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| Generic |
HYDROXYZINE (Henry Schein), HYDROXYZINE HCL (Advanced Rx Pharmacy of Tennessee), HYDROXYZINE HCL (Direct_rx), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (APOZEAL PHARMACEUTICALS), HYDROXYZINE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), HYDROXYZINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), HYDROXYZINE HYDROCHLORIDE (Advanced Rx of Tennessee), HYDROXYZINE HYDROCHLORIDE (Advanced Rx of Tennessee), HYDROXYZINE HYDROCHLORIDE (American Health Packaging), HYDROXYZINE HYDROCHLORIDE (American Regent), HYDROXYZINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), HYDROXYZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE HYDROCHLORIDE (Asclemed USA), HYDROXYZINE HYDROCHLORIDE (Aurobindo Pharma Limited), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Camber Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Cardinal Health 107), HYDROXYZINE HYDROCHLORIDE (Chartwell RX), HYDROXYZINE HYDROCHLORIDE (Chartwell RX), HYDROXYZINE HYDROCHLORIDE (Chartwell RX), HYDROXYZINE HYDROCHLORIDE (Chartwell RX), HYDROXYZINE HYDROCHLORIDE (Coupler LLC), HYDROXYZINE HYDROCHLORIDE (Coupler LLC), HYDROXYZINE HYDROCHLORIDE (Coupler LLC), HYDROXYZINE HYDROCHLORIDE (Direct Rx), HYDROXYZINE HYDROCHLORIDE (Epic Pharma), HYDROXYZINE HYDROCHLORIDE (Golden State Medical Supply), HYDROXYZINE HYDROCHLORIDE (HF Acquisition Co LLC), HYDROXYZINE HYDROCHLORIDE (Henry Schein), HYDROXYZINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (KVK-Tech), HYDROXYZINE HYDROCHLORIDE (Lannett Company), HYDROXYZINE HYDROCHLORIDE (Major Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Major Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Marlex Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), HYDROXYZINE HYDROCHLORIDE (Medsource Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NCS HealthCare of KY), HYDROXYZINE HYDROCHLORIDE (Northstar RxLLC), HYDROXYZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PAI Holdings), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PURACAP LABORATORIES LLC DBA BLU PHARMACEUTICALS), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals Incl), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE HYDROCHLORIDE (Rising Pharma Holdings), HYDROXYZINE HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), HYDROXYZINE HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), HYDROXYZINE HYDROCHLORIDE (St Mary's Medical Park Pharmacy), HYDROXYZINE HYDROCHLORIDE (Sunrise Pharmaceutical), HYDROXYZINE HYDROCHLORIDE (Teva Pharmaceuticals USA) |
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| Formula |
C21H27ClN2O2. 2HCl
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| Exact mass |
446.1295
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| Mol weight |
447.82
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| Structure |
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| Simcomp |
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00912): | D00672<JP/US> D01096<JP/US> |
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| Efficacy |
Antianxiety, Minor tranquilizer, H1 receptor antagonist |
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| Disease |
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| Comment |
In vitro studies suggested a role for CYP3A4 and CYP3A5 in the metabolism of Hydroxyzine.
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Interaction |
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BB Diphenylmethane derivatives
N05BB01 Hydroxyzine
D00672 Hydroxyzine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antiemetics
Antiemetics, Other
Hydroxyzine
D00672 Hydroxyzine hydrochloride (JP18/USP)
Anxiolytics
Anxiolytics, Other
Hydroxyzine
D00672 Hydroxyzine hydrochloride (JP18/USP)
Respiratory Tract/Pulmonary Agents
Antihistamines
Histamine (H1) Receptor Antagonists, Sedating
Hydroxyzine
D00672 Hydroxyzine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00672 Hydroxyzine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00912 Hydroxyzine
D00672 Hydroxyzine hydrochloride
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D00672 Hydroxyzine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00672 Hydroxyzine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00672 Hydroxyzine hydrochloride
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00912 Hydroxyzine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 28
1 C8x C 8.6800 -18.1300
2 C8y C 8.6800 -19.5300
3 C8x C 9.8924 -20.2300
4 C8x C 11.1049 -19.5300
5 C8y C 11.1049 -18.1300
6 C8x C 9.8924 -17.4300
7 C8x C 13.5297 -19.5300
8 C8y C 13.5297 -18.1300
9 C1c C 12.3173 -17.4300
10 N1y N 12.3173 -16.0300
11 C1x C 13.5318 -15.3288
12 C1x C 13.5318 -13.9288
13 N1y N 12.3193 -13.2288
14 C1x C 11.1049 -13.9300
15 C1x C 11.1049 -15.3300
16 C8x C 14.7422 -20.2300
17 C8x C 15.9546 -19.5300
18 C8x C 15.9546 -18.1300
19 C8x C 14.7422 -17.4300
20 X Cl 7.4676 -20.2300
21 C1b C 12.3193 -11.8300
22 C1b C 13.5323 -11.1297
23 O2a O 14.7280 -11.8202
24 C1b C 15.9152 -11.1349
25 C1b C 17.1065 -11.8229
26 O1a O 18.2960 -11.1362
27 X Cl 17.8500 -15.4000
28 X Cl 17.8500 -15.4000
BOND 28
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 14 15 1
16 10 15 1
17 7 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 8 19 2
22 2 20 1
23 13 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 25 26 1
BRACKET 1 16.2400 -16.2400 16.2400 -14.6300
1 18.6900 -14.6300 18.6900 -16.2400
1 2
ORIGINAL 1 27
REPEAT 1 28
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