KEGG   DRUG: Albuterol sulfate
Entry
D00683                      Drug                                   
Name
Albuterol sulfate (USP);
Salbutamol sulfate (JP18);
Accuneb (TN);
Proventil (TN);
Ventolin (TN)
Product
  Generic
ALBUTEROL (Amneal Pharmaceuticals NY LLC), ALBUTEROL (Aurobindo Pharma Limited), ALBUTEROL (Cadila Healthcare Limited), ALBUTEROL (Mylan Institutional), ALBUTEROL (Proficient Rx LP), ALBUTEROL (Rising Pharmaceuticals), ALBUTEROL (Virtus Pharmaceuticals LLC), ALBUTEROL (Zydus Pharmaceuticals (USA)), ALBUTEROL SULFATE (A-S Medication Solutions), ALBUTEROL SULFATE (A-S Medication Solutions), ALBUTEROL SULFATE HFA (A-S Medication Solutions), ALBUTEROL SULFATE (A-S Medication Solutions), ALBUTEROL SULFATE (A-S Medication Solutions), ALBUTEROL SULFATE (A-S Medication Solutions), ALBUTEROL SULFATE (A-S Medication Solutions), ALBUTEROL SULFATE (A-S Medication Solutions), ALBUTEROL SULFATE (ATLANTIC BIOLOGICALS CORP.), ALBUTEROL SULFATE (Actavis Pharma), ALBUTEROL SULFATE (Actavis Pharma), ALBUTEROL SULFATE (Akorn), ALBUTEROL SULFATE (Akorn), ALBUTEROL SULFATE (American Health Packaging), ALBUTEROL SULFATE (American Health Packaging), ALBUTEROL SULFATE (Asclemed USA), ALBUTEROL SULFATE (Aurobindo Pharma Limited), ALBUTEROL SULFATE (Aurobindo Pharma Limited), ALBUTEROL SULFATE (Bryant Ranch Prepack), ALBUTEROL SULFATE (Bryant Ranch Prepack), ALBUTEROL SULFATE (Cardinal Health 107), ALBUTEROL SULFATE (Cardinal Health), ALBUTEROL SULFATE (Chartwell RX), ALBUTEROL SULFATE (Cipla USA), ALBUTEROL SULFATE (Civica), ALBUTEROL SULFATE (DIRECT RX), ALBUTEROL SULFATE (Direct_Rx), ALBUTEROL SULFATE (Exelan Pharmaceuticals), ALBUTEROL SULFATE (Golden State Medical Supply), ALBUTEROL SULFATE (HF Acquisition Co LLC), ALBUTEROL SULFATE (HF Acquisition Co LLC), ALBUTEROL SULFATE (Hikma Pharmaceuticals USA), ALBUTEROL SULFATE (Lupin Pharmaceuticals), ALBUTEROL SULFATE (Medical Purchasing Solutions), ALBUTEROL (Mylan Pharmaceuticals), ALBUTEROL SULFATE (Mylan Pharmaceuticals), ALBUTEROL SULFATE (Mylan Pharmaceuticals), ALBUTEROL SULFATE (Nephron Pharmaceuticals Corporation), ALBUTEROL SULFATE (Nephron Pharmaceuticals Corporation), ALBUTEROL SULFATE (Nephron Pharmaceuticals Corporation), ALBUTEROL (Nivagen Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (NuCare Pharmaceuticals), ALBUTEROL SULFATE (Padagis Israel Pharmaceuticals), ALBUTEROL SULFATE (Par Pharmaceutical), ALBUTEROL SULFATE (Prasco Laboratories), ALBUTEROL SULATE (Preferred Pharmaceuticals), ALBUTEROL SULFATE (Preferred Pharmaceuticals), ALBUTEROL SULFATE (Preferred Pharmaceuticals), ALBUTEROL SULFATE (Preferred Pharmaceuticals), ALBUTEROL SULFATE (Proficient Rx LP), ALBUTEROL SULFATE (Proficient Rx LP), ALBUTEROL SULFATE (Proficient Rx LP), ALBUTEROL SULFATE (QUAGEN PHARMACEUTICALS LLC), ALBUTEROL SULFATE (Quality Care Products), ALBUTEROL SULFATE (REMEDYREPACK), ALBUTEROL SULFATE (REMEDYREPACK), ALBUTEROL SULFATE (REMEDYREPACK), ALBUTEROL SULFATE (RPK Pharmaceuticals), ALBUTEROL SULFATE (RPK Pharmaceuticals), ALBUTEROL SULFATE (RPK Pharmaceuticals), ALBUTEROL SULFATE (Ritedose Pharmaceuticals), ALBUTEROL SULFATE INHALATION SOLUTION (Ritedose Pharmaceuticals), ALBUTEROL SULFATE (Sandoz), ALBUTEROL SULFATE (Sun Pharmaceutical Industries), ALBUTEROL SULFATE (Sun Pharmaceutical Industries)
Formula
(C13H21NO3)2. H2SO4
Exact mass
576.2717
Mol weight
576.7
Structure
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
Remark
Therapeutic category: 2254
ATC code: R03AC02 R03CC02
Chemical structure group: DG01045
Product (DG01045): D00683<JP/US>
Product (mixture): D10256<US>
Efficacy
Bronchodilator, beta2-Adrenergic receptor agonist
Comment
Phenethylamine derivative
Treatment or prevention of bronchospasm
Target
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AC Selective beta-2-adrenoreceptor agonists
     R03AC02 Salbutamol
      D00683  Albuterol sulfate (USP) <JP/US>
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CC Selective beta-2-adrenoreceptor agonists
     R03CC02 Salbutamol
      D00683  Albuterol sulfate (USP) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Albuterol
    D00683  Albuterol sulfate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2254  Salbutamols
     D00683  Albuterol sulfate (USP); Salbutamol sulfate (JP18)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG01452  beta2-Adrenergic receptor agonist
     DG01045  Albuterol
      D00683  Albuterol sulfate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB2
     D00683  Albuterol sulfate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00683  Salbutamol sulfate
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG01452  beta2-Adrenergic receptor agonist
     DG01045  Albuterol
Other DBs
CAS: 51022-70-9
PubChem: 7847749
ChEBI: 2550
LigandBox: D00683
NIKKAJI: J268.936G
LinkDB
KCF data

ATOM        39
            1   C8y C    21.5532  -15.2544
            2   C8x C    20.2937  -15.9541
            3   C1c C    22.7428  -15.9541
            4   C8x C    21.5532  -13.8549
            5   C8y C    19.1041  -15.2544
            6   C1b C    23.9324  -15.2544
            7   O1a O    22.7428  -17.3536
            8   C8x C    20.2937  -13.1551
            9   C8y C    19.1041  -13.8549
            10  C1b C    17.9145  -15.9541
            11  N1b N    25.1919  -15.9541
            12  O1a O    17.9145  -13.1551
            13  O1a O    16.6550  -15.2544
            14  C1d C    26.3815  -15.2544
            15  C1a C    27.5711  -15.9541
            16  C1a C    26.3815  -13.8549
            17  C1a C    27.5935  -14.5546
            18  S4a S    32.8895  -15.4644
            19  O1d O    31.4899  -15.4644
            20  O1d O    34.2890  -15.4644
            21  O1d O    32.8895  -14.0649
            22  O1d O    32.8895  -16.8639
            23  C8y C    21.5532  -15.2544
            24  C8x C    20.2937  -15.9541
            25  C8y C    19.1041  -15.2544
            26  C8y C    19.1041  -13.8549
            27  O1a O    17.9145  -13.1551
            28  C8x C    20.2937  -13.1551
            29  C8x C    21.5532  -13.8549
            30  C1b C    17.9145  -15.9541
            31  O1a O    16.6550  -15.2544
            32  C1c C    22.7428  -15.9541
            33  C1b C    23.9324  -15.2544
            34  N1b N    25.1919  -15.9541
            35  C1d C    26.3815  -15.2544
            36  C1a C    27.5711  -15.9541
            37  C1a C    26.3815  -13.8549
            38  C1a C    27.5935  -14.5546
            39  O1a O    22.7428  -17.3536
BOND        38
            1    18  19 1
            2    18  20 1
            3    18  21 2
            4    18  22 2
            5     1   2 1
            6     1   3 1
            7     1   4 2
            8     2   5 2
            9     3   6 1
            10    3   7 1
            11    4   8 1
            12    5   9 1
            13    5  10 1
            14    6  11 1
            15    9  12 1
            16   10  13 1
            17   11  14 1
            18   14  15 1
            19   14  16 1
            20    8   9 2
            21   14  17 1
            22   23  24 1
            23   23  32 1
            24   23  29 2
            25   24  25 2
            26   32  33 1
            27   32  39 1
            28   29  28 1
            29   25  26 1
            30   25  30 1
            31   33  34 1
            32   26  27 1
            33   30  31 1
            34   34  35 1
            35   35  36 1
            36   35  37 1
            37   28  26 2
            38   35  38 1
BRACKET     1    15.1900  -18.4800   15.1900  -11.7600
            1    29.3300  -11.7600   29.3300  -18.4800
            1  2
 ORIGINAL  1    1   2   5   9  12   8   4  10  13   3   6  11  14  15  16  17
            1    7
 REPEAT    1   23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38
            1   39

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