KEGG   DRUG: Diclofenac potassium
Entry
D00903                      Drug                                   

Name
Diclofenac potassium (USP);
Cambia (TN);
Cataflam (TN);
Zipsor (TN)
Product
  Generic
DICLOFENAC POTASSIUM (A-S Medication Solutions), DICLOFENAC POTASSIUM (A-S Medication Solutions), DICLOFENAC POTASSIUM (Advagen Pharma), DICLOFENAC POTASSIUM (Amici Pharmaceuticals LLC.), CATAFLAM (BLUCREST PHARMACEUTICALS), DICLOFENAC POTASSIUM (Bryant Ranch Prepack), DICLOFENAC POTASSIUM (Bryant Ranch Prepack), DICLOFENAC POTASSIUM (Bryant Ranch Prepack), DICLOFENAC POTASSIUM (DIRECT RX), DICLOFENAC POTASSIUM (Lake Erie Medical DBA Quality Care Products LLC), DICLOFENAC POTASSIUM (Mylan Pharmaceuticals), DICLOFENAC POTASSIUM (NuCare Pharmaceuticals), DICLOFENAC POTASSIUM (PD-Rx Pharmaceuticals), DICLOFENAC POTASSIUM (PD-Rx Pharmaceuticals), DICLOFENAC POTASSIUM (Par Pharmaceutical), DICLOFENAC POTASSIUM (REMEDYREPACK), DICLOFENAC POTASSIUM (REMEDYREPACK), DICLOFENAC POTASSIUM (RPK Pharmaceuticals), DICLOFENAC POTASSIUM (RedPharm Drug), DICLOFENAC POTASSIUM (RedPharm Drug), DICLOFENAC POTASSIUM (Teva Pharmaceuticals USA)
Formula
C14H10Cl2NO2. K
Exact mass
332.9726
Mol weight
334.239
Structure
Simcomp
Class
Anti-inflammatory
 DG01906  Anti-inflammatory drug, acetic acid derivatives
  DG01898  Anti-inflammatory drug, phenylacetic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01906  Anti-inflammatory drug, acetic acid derivatives
   DG01898  Anti-inflammatory drug, phenylacetic acid derivatives
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Transporter inhibitor
 DG02866  SLC22A8 (OAT3) inhibitor
Remark
ATC code: D11AX18 M01AB05 M02AA15 S01BC03
Chemical structure group: DG00441
Product (DG00441): D07816<US> D00903<US> D00904<JP/US> D07818<US>
Efficacy
Anti-inflammatory, COX inhibitor
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Transporter inhibition: SLC22A8 [HSA:9376]
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX18 Diclofenac
      D00903  Diclofenac potassium (USP) <US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB05 Diclofenac
      D00903  Diclofenac potassium (USP) <US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA15 Diclofenac
      D00903  Diclofenac potassium (USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC03 Diclofenac
      D00903  Diclofenac potassium (USP) <US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Diclofenac
    D00903  Diclofenac potassium (USP)
 Dermatological Agents
  Dermatological Agents, Other
   Warts and Actinic Keratosis Agents
    Diclofenac
     D00903  Diclofenac potassium (USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
    Diclofenac
     D00903  Diclofenac potassium (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00903  Diclofenac potassium (USP) <US>
    PTGS2 (COX2)
     D00903  Diclofenac potassium (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00903
 Drug transporters
  D00903
Other DBs
CAS: 15307-81-0
PubChem: 7847967
ChEBI: 4508
ChEMBL: CHEMBL1200804
DrugBank: DB00586
LigandBox: D00903
NIKKAJI: J435.105C
LinkDB
KCF data

ATOM        20
            1   Z   K    45.1317  -36.4561 #+
            2   C8x C    37.3100  -37.1000
            3   C8x C    37.3100  -38.5000
            4   C8x C    38.5224  -39.2000
            5   C8x C    39.7349  -38.5000
            6   C8y C    39.7349  -37.1000
            7   C8y C    38.5224  -36.4000
            8   C1b C    40.9660  -36.3890
            9   C6a C    42.1712  -37.0847
            10  O6a O    43.3535  -36.4019 #-
            11  O6a O    42.1716  -38.4996
            12  N1b N    38.5224  -35.0002
            13  C8y C    37.2932  -34.2903
            14  C8y C    37.2935  -32.9001
            15  C8x C    36.0812  -32.1999
            16  C8x C    34.8686  -32.8996
            17  C8x C    34.8683  -34.2898
            18  C8y C    36.0806  -34.9901
            19  X   Cl   38.5184  -32.1931
            20  X   Cl   36.0806  -36.3997
BOND        20
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 2
            11    7  12 1
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   13  18 1
            19   14  19 1
            20   18  20 1

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