KEGG   DRUG: Pamidronate disodiumHelp
Entry
D00941                      Drug                                   

Name
Pamidronate disodium (USAN);
Pamidronate disodium hydrate (JAN);
Pamidronate disodium pentahydrate;
Aredia (TN)
Product
  Generic
Formula
C3H9NO7P2. 5H2O. 2Na
Exact mass
369.0178
Mol weight
369.1095
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01600  Bisphosphonate
Remark
Therapeutic category: 3999
ATC code: M05BA03
Chemical structure group: DG00782
Product (DG00782): D00941<JP/US>
Efficacy
Antihypercalcemia, Antiresorptive, Farnesylpyrophosphate synthetase inhibitor
  Disease
Paget's disease of bone [DS:H00437]
Target
FDPS [HSA:2224] [KO:K00787]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Interaction
Drug interaction
Structure map
map07047  Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M05 DRUGS FOR TREATMENT OF BONE DISEASES
   M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
    M05BA Bisphosphonates
     M05BA03 Pamidronic acid
      D00941  Pamidronate disodium (USAN) <JP/US>
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Bisphosphonates
   Pamidronate
    D00941  Pamidronate disodium (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D00941  Pamidronate disodium (USAN); Pamidronate disodium hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Alkyl/Aryl transferases
    FDPS
     D00941  Pamidronate disodium (USAN) <JP/US>
Antineoplastics [br08340.html]
 D00941
BRITE hierarchy
Other DBs
CAS: 109552-15-0
PubChem: 7848004
ChEBI: 7904
ChEMBL: CHEMBL3989401
DrugBank: DB00282
LigandBox: D00941
NIKKAJI: J1.631.466H
LinkDB All DBs
KCF data Show

ATOM        20
            1   Z   Na   19.9441  -25.8315 #+
            2   Z   Na   26.4457  -25.8885 #+
            3   O0  O    30.8700  -23.6600
            4   C1d C    23.5200  -23.5900
            5   P1b P    21.9800  -23.5900
            6   P1b P    25.2700  -23.5900
            7   C1b C    23.5200  -22.4700
            8   O1a O    23.5200  -24.9900
            9   O1c O    20.6500  -23.5900
            10  O1c O    21.9800  -24.9900 #-
            11  O1c O    21.9800  -22.1200
            12  O1c O    25.2700  -25.0600 #-
            13  O1c O    25.2700  -22.0500
            14  O1c O    26.6000  -23.5900
            15  C1b C    24.5000  -21.9800
            16  N1a N    24.5000  -20.5800
            17  O0  O    30.8700  -23.6600
            18  O0  O    30.8700  -23.6600
            19  O0  O    30.8700  -23.6600
            20  O0  O    30.8700  -23.6600
BOND        12
            1     4   5 1
            2     4   6 1
            3     4   7 1
            4     4   8 1
            5     5   9 1
            6     5  10 1
            7     5  11 2
            8     6  12 1
            9     6  13 2
            10    6  14 1
            11    7  15 1
            12   15  16 1
BRACKET     1    28.8400  -24.7100   28.8400  -22.6800
            1    31.7100  -22.6800   31.7100  -24.7100
            1  5
 ORIGINAL  1    3
 REPEAT    1   17  18  19  20

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