| Entry |
|
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| Name |
Pamidronate disodium (USP);
Pamidronate disodium hydrate (JAN);
Pamidronate disodium pentahydrate;
Aredia (TN) |
|---|
| Product |
|
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| Generic |
|
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| Formula |
C3H9NO7P2. 5H2O. 2Na
|
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| Exact mass |
369.0178
|
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| Mol weight |
369.11
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Musculo-skeletal system agent
DG03232 Osteoporosis agent
DG01600 Bisphosphonate
|
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| Remark |
| Therapeutic category: | 3999 |
| Product (DG00782): | D00941<JP/US> |
|
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| Efficacy |
Antihypercalcemia, Antiresorptive, Farnesylpyrophosphate synthetase inhibitor |
|---|
| Disease |
Paget's disease of bone [DS: H00437] |
|---|
| Target |
|
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| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
|
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M05 DRUGS FOR TREATMENT OF BONE DISEASES
M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
M05BA Bisphosphonates
M05BA03 Pamidronic acid
D00941 Pamidronate disodium (USP) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Antineoplastic Adjuncts/Mitigators
Pamidronate
D00941 Pamidronate disodium (USP)
Metabolic Bone Disease Agents
Bisphosphonates
Pamidronate
D00941 Pamidronate disodium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
399 Miscellaneous
3999 Others
D00941 Pamidronate disodium (USP); Pamidronate disodium hydrate (JAN)
Drug groups [BR:br08330]
Musculo-skeletal system agent
DG03232 Osteoporosis agent
DG01600 Bisphosphonate
DG00782 Pamidronic acid
D00941 Pamidronate disodium
Drug classes [BR:br08332]
Musculo-skeletal system agent
DG03232 Osteoporosis agent
D00941 Pamidronate disodium
Target-based classification of drugs [BR:br08310]
Enzymes
Transferases (EC2)
Alkyl/Aryl transferases
FDPS
D00941 Pamidronate disodium (USP) <JP/US>
Drug groups [BR:br08330]
Musculo-skeletal system agent
DG03232 Osteoporosis agent
DG01600 Bisphosphonate
DG00782 Pamidronic acid
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 20
1 Z Na 19.9441 -25.8315 #+
2 Z Na 26.4457 -25.8885 #+
3 O0 O 30.8700 -23.6600
4 C1d C 23.5200 -23.5900
5 P1b P 21.9800 -23.5900
6 P1b P 25.2700 -23.5900
7 C1b C 23.5200 -22.4700
8 O1a O 23.5200 -24.9900
9 O1c O 20.6500 -23.5900
10 O1c O 21.9800 -24.9900 #-
11 O1c O 21.9800 -22.1200
12 O1c O 25.2700 -25.0600 #-
13 O1c O 25.2700 -22.0500
14 O1c O 26.6000 -23.5900
15 C1b C 24.5000 -21.9800
16 N1a N 24.5000 -20.5800
17 O0 O 30.8700 -23.6600
18 O0 O 30.8700 -23.6600
19 O0 O 30.8700 -23.6600
20 O0 O 30.8700 -23.6600
BOND 12
1 4 5 1
2 4 6 1
3 4 7 1
4 4 8 1
5 5 9 1
6 5 10 1
7 5 11 2
8 6 12 1
9 6 13 2
10 6 14 1
11 7 15 1
12 15 16 1
BRACKET 1 28.8400 -24.7100 28.8400 -22.6800
1 31.7100 -22.6800 31.7100 -24.7100
1 5
ORIGINAL 1 3
REPEAT 1 17 18 19 20
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