Entry |
|
Name |
Daptomycin (JAN/USAN/INN); Cubicin (TN) |
Abbr |
DAP |
Product |
|
Generic |
DAPTOMYCIN (Accord Healthcare), DAPTOMYCIN (Accord Healthcare), DAPTOMYCIN (BE Pharmaceuticals), DAPTOMYCIN (BE Pharmaceuticals), DAPTOMYCIN (BluePoint Laboratories), DAPTOMYCIN (BluePoint Laboratories), DAPTOMYCIN (Camber Pharmaceuticals), DAPTOMYCIN (Cipla USA), DAPTOMYCIN (Civica), DAPTOMYCIN (Dr.Reddy's Laboratories Inc.,), DAPTOMYCIN (Fresenius Kabi USA), DAPTOMYCIN (Fresenius Kabi USA), DAPTOMYCIN (Fresenius Kabi USA), DAPTOMYCIN (Hikma Pharmaceuticals USA), DAPTOMYCIN (Hospira), DAPTOMYCIN (Meitheal Pharmaceuticals), DAPTOMYCIN (Mylan Institutional LLC), DAPTOMYCIN (NorthStar RxLLC), DAPTOMYCIN (Sagent Pharmaceuticals), DAPTOMYCIN (Sandoz), DAPTOMYCIN (Teva Parenteral Medicines), DAPTOMYCIN (Xellia Pharmaceuticals USA LLC) |
Formula |
C72H101N17O26
|
Exact mass |
1619.7104
|
Mol weight |
1620.6706
|
Structure |

|
Simcomp |
|
Sequence |
0 FA 1 Trp 2 D-Asn 3 Asp 4 Thr 5 Gly 6 Orn 7 Asp 8 D-Ala 9 Asp 10 Gly 11 D-Ser 12 threo-Glu 13 Kyn (Cyclization: 4-13) |
Type |
NRP |
Source |
Streptomyces roseosporus [TAX: 67294]
|
Remark |
Therapeutic category: | 6119 |
|
Efficacy |
Antibacterial, Cell membrane function inhibitor |
Disease |
Infective endocarditis [DS: H00334] |
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XX Other antibacterials
J01XX09 Daptomycin
D01080 Daptomycin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Daptomycin
D01080 Daptomycin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
611 Acting mainly on gram-positive bacteria
6119 Others
D01080 Daptomycin (JAN/USAN/INN)
Antiinfectives [BR:br08307]
Antibacterials
Cell membrane function inhibitor
Lipopeptide
D01080 Daptomycin (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D01080
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D01080
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01080
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01080
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 115
1 C1a C 11.1300 -23.9400
2 C1b C 12.3200 -24.6400
3 C1b C 13.5800 -23.9400
4 C1b C 14.7700 -24.6400
5 C1b C 15.9600 -23.9400
6 C1b C 17.2200 -24.6400
7 C1b C 18.4100 -23.9400
8 C1b C 19.6000 -24.6400
9 C1b C 20.8600 -23.9400
10 C5a C 22.0500 -24.6400
11 N1b N 23.3100 -24.0100
12 O5a O 22.0500 -26.0400
13 C1c C 24.5000 -24.7100
14 C5a C 25.7600 -24.0100
15 N1b N 26.9500 -24.7800
16 O5a O 25.7600 -22.6100
17 C1c C 28.1400 -24.0800
18 C5a C 29.3300 -24.7800
19 C1b C 28.1400 -22.6800
20 C5a C 29.3300 -21.9800
21 N1a N 30.5200 -22.6800
22 O5a O 29.3300 -20.5800
23 N1b N 30.5900 -24.1500
24 C1c C 31.7800 -24.8500
25 O5a O 29.3300 -26.1800
26 C1b C 24.5000 -26.1100
27 C8y C 25.6900 -26.8100
28 C8y C 26.1100 -28.1400
29 C8y C 27.5100 -28.1400
30 N4x N 27.9300 -26.8100
31 C8x C 26.8100 -26.0400
32 C8x C 25.4100 -29.3300
33 C8x C 26.1800 -30.5900
34 C8x C 27.5100 -30.5900
35 C8x C 28.2100 -29.3300
36 C5a C 33.0400 -24.1500
37 C1b C 31.7800 -26.2500
38 C6a C 32.9700 -26.9500
39 O6a O 34.2300 -26.3200
40 O6a O 32.9700 -28.3500
41 N1b N 34.2300 -24.9200
42 O5a O 33.0400 -22.7500
43 C1c C 35.4200 -24.2200
44 C1c C 36.9600 -24.9200
45 C5a C 35.4200 -22.8200
46 O5a O 36.6100 -22.1200
47 N1b N 34.2300 -22.1200
48 C1b C 34.2300 -20.7200
49 C5a C 33.0400 -20.0200
50 O5a O 31.8500 -20.7200
51 N1b N 33.0400 -18.6200
52 C1c C 31.8500 -17.9200
53 C1b C 30.6600 -18.6200
54 C5a C 31.8500 -16.5200
55 C1b C 29.4700 -17.9200
56 C1b C 28.2800 -18.6200
57 N1a N 27.0900 -17.9200
58 O5a O 30.6600 -15.8200
59 N1b N 33.0400 -15.8200
60 C1c C 33.7400 -14.6300
61 C5a C 35.1400 -14.6300
62 N1b N 35.8400 -15.8200
63 C1b C 33.0400 -13.3700
64 C6a C 31.6400 -13.3700
65 O6a O 30.9400 -12.1800
66 O6a O 30.9400 -14.5600
67 O5a O 35.8400 -13.4400
68 C1c C 37.0300 -16.5200
69 C5a C 38.2200 -15.8200
70 C1a C 37.0300 -17.9200
71 N1b N 39.4100 -16.5200
72 O5a O 38.2200 -14.4200
73 C1c C 40.6000 -15.8200
74 C5a C 41.7900 -16.5200
75 C1b C 40.6000 -14.4200
76 C6a C 41.7900 -13.7200
77 O6a O 43.0500 -14.4200
78 O6a O 41.7900 -12.3200
79 N1b N 42.9800 -15.8200
80 O5a O 41.7900 -17.9200
81 C1b C 44.2400 -16.5200
82 C5a C 44.2400 -17.9200
83 N1b N 42.9800 -18.6200
84 O5a O 45.4300 -18.6200
85 C1c C 42.9800 -20.0200
86 C5a C 41.7900 -20.7200
87 C1b C 44.2400 -20.6500
88 O1a O 45.4300 -19.9500
89 O5a O 40.6000 -20.0200
90 N1b N 41.7900 -22.1200
91 C1c C 40.6000 -22.8200
92 C1c C 39.4100 -22.1200
93 C5a C 40.6000 -24.2200
94 N1b N 39.4100 -24.9200
95 O5a O 41.7900 -24.9200
96 C1c C 39.4100 -26.3200
97 C7a C 38.1500 -27.0200
98 C1b C 40.6000 -27.0200
99 O7a O 36.9600 -26.3200
100 O6a O 38.1500 -28.4200
101 C1a C 38.1500 -24.1500
102 C1b C 39.4100 -20.7200
103 C1a C 38.2200 -22.8200
104 C6a C 38.2200 -20.0200
105 O6a O 37.0300 -20.7200
106 O6a O 38.2200 -18.6200
107 C5a C 40.6000 -28.4200
108 O5a O 39.4100 -29.1200
109 C8y C 41.7900 -29.1200
110 C8x C 41.7900 -30.5200
111 C8x C 43.0500 -31.2200
112 C8x C 44.2400 -30.5200
113 C8x C 44.2400 -29.1200
114 C8y C 43.0500 -28.4200
115 N1a N 43.0500 -27.0200
BOND 118
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 6 7 1
7 7 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 10 12 2
12 11 13 1
13 13 14 1
14 14 15 1
15 14 16 2
16 15 17 1
17 17 18 1
18 17 19 1 #Down
19 19 20 1
20 20 21 1
21 20 22 2
22 18 23 1
23 23 24 1
24 18 25 2
25 13 26 1 #Down
26 26 27 1
27 27 28 1
28 28 29 1
29 29 30 1
30 30 31 1
31 27 31 2
32 28 32 2
33 32 33 1
34 33 34 2
35 34 35 1
36 29 35 2
37 24 36 1
38 24 37 1 #Down
39 37 38 1
40 38 39 1
41 38 40 2
42 36 41 1
43 36 42 2
44 43 41 1 #Down
45 43 44 1
46 43 45 1
47 45 46 2
48 45 47 1
49 47 48 1
50 48 49 1
51 49 50 2
52 49 51 1
53 51 52 1
54 52 53 1 #Up
55 52 54 1
56 53 55 1
57 55 56 1
58 56 57 1
59 54 58 2
60 54 59 1
61 59 60 1
62 60 61 1
63 61 62 1
64 60 63 1 #Up
65 63 64 1
66 64 65 1
67 64 66 2
68 61 67 2
69 62 68 1
70 68 69 1
71 68 70 1 #Up
72 69 71 1
73 69 72 2
74 71 73 1
75 73 74 1
76 73 75 1 #Up
77 75 76 1
78 76 77 1
79 76 78 2
80 74 79 1
81 74 80 2
82 79 81 1
83 81 82 1
84 82 83 1
85 82 84 2
86 83 85 1
87 85 86 1
88 85 87 1 #Down
89 87 88 1
90 86 89 2
91 86 90 1
92 90 91 1
93 91 92 1
94 91 93 1
95 93 94 1
96 93 95 2
97 94 96 1
98 96 97 1
99 96 98 1 #Up
100 97 99 1
101 97 100 2
102 99 44 1
103 44 101 1 #Up
104 92 102 1
105 92 103 1 #Down
106 102 104 1
107 104 105 1
108 104 106 2
109 98 107 1
110 107 108 2
111 107 109 1
112 109 110 2
113 110 111 1
114 111 112 2
115 112 113 1
116 113 114 2
117 109 114 1
118 114 115 1
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