KEGG   DRUG: Daptomycin
Entry
D01080                      Drug                                   
Name
Daptomycin (JAN/USAN/INN);
Cubicin (TN)
  Abbr
DAP
Product
DAPZURA RT (Baxter Healthcare Corporation), DAPTOMYCIN (Civica), DAPTOMYCIN (Fresenius Kabi USA), DAPTOMYCIN (Hospira), DAPTOMYCIN (Hospira), CUBICIN RF (Merck Sharp & Dohme LLC), CUBICIN RF (Merck Sharp & Dohme LLC), CUBICIN (Merck Sharp & Dohme LLC), DAPTOMYCIN (Sagent Pharmaceuticals), DAPTOMYCIN (Sagent Pharmaceuticals), DAPTOMYCIN (Xellia Pharmaceuticals USA LLC)
  Generic
DAPTOMYCIN (APOTEX CORP.), DAPTOMYCIN (Accord Healthcare), DAPTOMYCIN (Accord Healthcare), DAPTOMYCIN (AuroMedics Pharma LLC), DAPTOMYCIN (BE Pharmaceuticals), DAPTOMYCIN (BE Pharmaceuticals), DAPTOMYCIN (BluePoint Laboratories), DAPTOMYCIN (BluePoint Laboratories), DAPTOMYCIN (Camber Pharmaceuticals), DAPTOMYCIN (Camber Pharmaceuticals), DAPTOMYCIN (Cipla USA), DAPTOMYCIN (Cipla USA), DAPTOMYCIN (Civica), DAPTOMYCIN (Dr. Reddy's Laboratories Inc.,), DAPTOMYCIN (Dr.Reddy's Laboratories Inc.,), DAPTOMYCIN (Fresenius Kabi USA), DAPTOMYCIN (Fresenius Kabi USA), DAPTOMYCIN (Fresenius Kabi USA), DAPTOMYCIN (Hikma Pharmaceuticals USA), DAPTOMYCIN (Hospira), DAPTOMYCIN (Meitheal Pharmaceuticals), DAPTOMYCIN (Meitheal Pharmaceuticals), DAPTOMYCIN (Meitheal Pharmaceuticals), DAPTOMYCIN (Meitheal Pharmaceuticals), DAPTOMYCIN (Meitheal Pharmaceuticals), DAPTOMYCIN (Meitheal Pharmaceuticals), DAPTOMYCIN (Mylan Institutional LLC), DAPTOMYCIN (NorthStar RxLLC), DAPTOMYCIN (Qilu Pharmaceutical), DAPTOMYCIN (Sagent Pharmaceuticals), DAPTOMYCIN (Sandoz), DAPTOMYCIN (Slate Run Pharmaceuticals), DAPTOMYCIN (Teva Parenteral Medicines), DAPTOMYCIN (Xellia Pharmaceuticals LLC), DAPTOMYCIN (Xellia Pharmaceuticals USA LLC)
Formula
C72H101N17O26
Exact mass
1619.7104
Mol weight
1620.6706
Structure
Simcomp
Sequence
0 FA  1 Trp  2 D-Asn  3 Asp  4 Thr  5 Gly  6 Orn  7 Asp  8 D-Ala
9 Asp  10 Gly  11 D-Ser  12 threo-Glu  13 Kyn  (Cyclization: 4-13)
  Type
NRP
Source
Streptomyces roseosporus [TAX:67294]
Remark
Same as: C12013
Therapeutic category: 6119
ATC code: J01XX09
Product: D01080<JP/US>
Efficacy
Antibacterial, Cell membrane function inhibitor
  Disease
Infective endocarditis [DS:H00334]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XX Other antibacterials
     J01XX09 Daptomycin
      D01080  Daptomycin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Daptomycin
    D01080  Daptomycin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   611  Acting mainly on gram-positive bacteria
    6119  Others
     D01080  Daptomycin (JAN/USAN/INN)
Antimicrobials [BR:br08307]
 Antibacterials
  Cell membrane function inhibitor
   Lipopeptide
    D01080  Daptomycin (JAN/USAN/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell membrane function inhibitor
   Lipopeptide
    D01080  Daptomycin (JAN/USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01080
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01080
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01080
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01080
Other DBs
CAS: 103060-53-3
PubChem: 7848143
ChEBI: 600103
LigandBox: D01080
NIKKAJI: J359.001A
LinkDB
KCF data

ATOM        115
            1   C1a C    11.1300  -23.9400
            2   C1b C    12.3200  -24.6400
            3   C1b C    13.5800  -23.9400
            4   C1b C    14.7700  -24.6400
            5   C1b C    15.9600  -23.9400
            6   C1b C    17.2200  -24.6400
            7   C1b C    18.4100  -23.9400
            8   C1b C    19.6000  -24.6400
            9   C1b C    20.8600  -23.9400
            10  C5a C    22.0500  -24.6400
            11  N1b N    23.3100  -24.0100
            12  O5a O    22.0500  -26.0400
            13  C1c C    24.5000  -24.7100
            14  C5a C    25.7600  -24.0100
            15  N1b N    26.9500  -24.7800
            16  O5a O    25.7600  -22.6100
            17  C1c C    28.1400  -24.0800
            18  C5a C    29.3300  -24.7800
            19  C1b C    28.1400  -22.6800
            20  C5a C    29.3300  -21.9800
            21  N1a N    30.5200  -22.6800
            22  O5a O    29.3300  -20.5800
            23  N1b N    30.5900  -24.1500
            24  C1c C    31.7800  -24.8500
            25  O5a O    29.3300  -26.1800
            26  C1b C    24.5000  -26.1100
            27  C8y C    25.6900  -26.8100
            28  C8y C    26.1100  -28.1400
            29  C8y C    27.5100  -28.1400
            30  N4x N    27.9300  -26.8100
            31  C8x C    26.8100  -26.0400
            32  C8x C    25.4100  -29.3300
            33  C8x C    26.1800  -30.5900
            34  C8x C    27.5100  -30.5900
            35  C8x C    28.2100  -29.3300
            36  C5a C    33.0400  -24.1500
            37  C1b C    31.7800  -26.2500
            38  C6a C    32.9700  -26.9500
            39  O6a O    34.2300  -26.3200
            40  O6a O    32.9700  -28.3500
            41  N1b N    34.2300  -24.9200
            42  O5a O    33.0400  -22.7500
            43  C1c C    35.4200  -24.2200
            44  C1c C    36.9600  -24.9200
            45  C5a C    35.4200  -22.8200
            46  O5a O    36.6100  -22.1200
            47  N1b N    34.2300  -22.1200
            48  C1b C    34.2300  -20.7200
            49  C5a C    33.0400  -20.0200
            50  O5a O    31.8500  -20.7200
            51  N1b N    33.0400  -18.6200
            52  C1c C    31.8500  -17.9200
            53  C1b C    30.6600  -18.6200
            54  C5a C    31.8500  -16.5200
            55  C1b C    29.4700  -17.9200
            56  C1b C    28.2800  -18.6200
            57  N1a N    27.0900  -17.9200
            58  O5a O    30.6600  -15.8200
            59  N1b N    33.0400  -15.8200
            60  C1c C    33.7400  -14.6300
            61  C5a C    35.1400  -14.6300
            62  N1b N    35.8400  -15.8200
            63  C1b C    33.0400  -13.3700
            64  C6a C    31.6400  -13.3700
            65  O6a O    30.9400  -12.1800
            66  O6a O    30.9400  -14.5600
            67  O5a O    35.8400  -13.4400
            68  C1c C    37.0300  -16.5200
            69  C5a C    38.2200  -15.8200
            70  C1a C    37.0300  -17.9200
            71  N1b N    39.4100  -16.5200
            72  O5a O    38.2200  -14.4200
            73  C1c C    40.6000  -15.8200
            74  C5a C    41.7900  -16.5200
            75  C1b C    40.6000  -14.4200
            76  C6a C    41.7900  -13.7200
            77  O6a O    43.0500  -14.4200
            78  O6a O    41.7900  -12.3200
            79  N1b N    42.9800  -15.8200
            80  O5a O    41.7900  -17.9200
            81  C1b C    44.2400  -16.5200
            82  C5a C    44.2400  -17.9200
            83  N1b N    42.9800  -18.6200
            84  O5a O    45.4300  -18.6200
            85  C1c C    42.9800  -20.0200
            86  C5a C    41.7900  -20.7200
            87  C1b C    44.2400  -20.6500
            88  O1a O    45.4300  -19.9500
            89  O5a O    40.6000  -20.0200
            90  N1b N    41.7900  -22.1200
            91  C1c C    40.6000  -22.8200
            92  C1c C    39.4100  -22.1200
            93  C5a C    40.6000  -24.2200
            94  N1b N    39.4100  -24.9200
            95  O5a O    41.7900  -24.9200
            96  C1c C    39.4100  -26.3200
            97  C7a C    38.1500  -27.0200
            98  C1b C    40.6000  -27.0200
            99  O7a O    36.9600  -26.3200
            100 O6a O    38.1500  -28.4200
            101 C1a C    38.1500  -24.1500
            102 C1b C    39.4100  -20.7200
            103 C1a C    38.2200  -22.8200
            104 C6a C    38.2200  -20.0200
            105 O6a O    37.0300  -20.7200
            106 O6a O    38.2200  -18.6200
            107 C5a C    40.6000  -28.4200
            108 O5a O    39.4100  -29.1200
            109 C8y C    41.7900  -29.1200
            110 C8x C    41.7900  -30.5200
            111 C8x C    43.0500  -31.2200
            112 C8x C    44.2400  -30.5200
            113 C8x C    44.2400  -29.1200
            114 C8y C    43.0500  -28.4200
            115 N1a N    43.0500  -27.0200
BOND        118
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   10  12 2
            12   11  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 2
            16   15  17 1
            17   17  18 1
            18   17  19 1 #Down
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   18  23 1
            23   23  24 1
            24   18  25 2
            25   13  26 1 #Down
            26   26  27 1
            27   27  28 1
            28   28  29 1
            29   29  30 1
            30   30  31 1
            31   27  31 2
            32   28  32 2
            33   32  33 1
            34   33  34 2
            35   34  35 1
            36   29  35 2
            37   24  36 1
            38   24  37 1 #Down
            39   37  38 1
            40   38  39 1
            41   38  40 2
            42   36  41 1
            43   36  42 2
            44   43  41 1 #Down
            45   43  44 1
            46   43  45 1
            47   45  46 2
            48   45  47 1
            49   47  48 1
            50   48  49 1
            51   49  50 2
            52   49  51 1
            53   51  52 1
            54   52  53 1 #Up
            55   52  54 1
            56   53  55 1
            57   55  56 1
            58   56  57 1
            59   54  58 2
            60   54  59 1
            61   59  60 1
            62   60  61 1
            63   61  62 1
            64   60  63 1 #Up
            65   63  64 1
            66   64  65 1
            67   64  66 2
            68   61  67 2
            69   62  68 1
            70   68  69 1
            71   68  70 1 #Up
            72   69  71 1
            73   69  72 2
            74   71  73 1
            75   73  74 1
            76   73  75 1 #Up
            77   75  76 1
            78   76  77 1
            79   76  78 2
            80   74  79 1
            81   74  80 2
            82   79  81 1
            83   81  82 1
            84   82  83 1
            85   82  84 2
            86   83  85 1
            87   85  86 1
            88   85  87 1 #Down
            89   87  88 1
            90   86  89 2
            91   86  90 1
            92   90  91 1
            93   91  92 1
            94   91  93 1
            95   93  94 1
            96   93  95 2
            97   94  96 1
            98   96  97 1
            99   96  98 1 #Up
            100  97  99 1
            101  97 100 2
            102  99  44 1
            103  44 101 1 #Up
            104  92 102 1
            105  92 103 1 #Down
            106 102 104 1
            107 104 105 1
            108 104 106 2
            109  98 107 1
            110 107 108 2
            111 107 109 1
            112 109 110 2
            113 110 111 1
            114 111 112 2
            115 112 113 1
            116 113 114 2
            117 109 114 1
            118 114 115 1

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