| Entry |
|
|---|
| Name |
Daptomycin (JAN/USAN/INN);
Cubicin (TN)
|
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C72H101N17O26
|
|---|
| Exact mass |
1619.7104
|
|---|
| Mol weight |
1620.6706
|
|---|
| Structure |
   |
|---|
| Simcomp |
 |
|---|
| Sequence |
0 FA 1 Trp 2 D-Asn 3 Asp 4 Thr 5 Gly 6 Orn 7 Asp 8 D-Ala
9 Asp 10 Gly 11 D-Ser 12 threo-Glu 13 Kyn (Cyclization: 4-13) |
|---|
| Type |
NRP |
|---|
| Source |
Streptomyces roseosporus [TAX: 67294]
|
|---|
| Remark |
| Therapeutic category: | 6119 |
|
|---|
| Efficacy |
Antibacterial, Cell membrane function inhibitor |
|---|
| Disease |
Infective endocarditis [DS: H00334] |
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XX Other antibacterials
J01XX09 Daptomycin
D01080 Daptomycin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Daptomycin
D01080 Daptomycin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
611 Acting mainly on gram-positive bacteria
6119 Others
D01080 Daptomycin (JAN/USAN/INN)
Antiinfectives [br08350.html]
Antibacterials
D01080
New drug approvals in the USA [br08319.html]
New Molecular Entity and New Therapeutic Biological Product Approvals
D01080
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D01080
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01080
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01080
 |
|---|
| Other DBs |
|
|---|
| LinkDB |
 |
|---|
| KCF data |
ATOM 115
1 C1a C 11.1300 -23.9400
2 C1b C 12.3200 -24.6400
3 C1b C 13.5800 -23.9400
4 C1b C 14.7700 -24.6400
5 C1b C 15.9600 -23.9400
6 C1b C 17.2200 -24.6400
7 C1b C 18.4100 -23.9400
8 C1b C 19.6000 -24.6400
9 C1b C 20.8600 -23.9400
10 C5a C 22.0500 -24.6400
11 N1b N 23.3100 -24.0100
12 O5a O 22.0500 -26.0400
13 C1c C 24.5000 -24.7100
14 C5a C 25.7600 -24.0100
15 N1b N 26.9500 -24.7800
16 O5a O 25.7600 -22.6100
17 C1c C 28.1400 -24.0800
18 C5a C 29.3300 -24.7800
19 C1b C 28.1400 -22.6800
20 C5a C 29.3300 -21.9800
21 N1a N 30.5200 -22.6800
22 O5a O 29.3300 -20.5800
23 N1b N 30.5900 -24.1500
24 C1c C 31.7800 -24.8500
25 O5a O 29.3300 -26.1800
26 C1b C 24.5000 -26.1100
27 C8y C 25.6900 -26.8100
28 C8y C 26.1100 -28.1400
29 C8y C 27.5100 -28.1400
30 N4x N 27.9300 -26.8100
31 C8x C 26.8100 -26.0400
32 C8x C 25.4100 -29.3300
33 C8x C 26.1800 -30.5900
34 C8x C 27.5100 -30.5900
35 C8x C 28.2100 -29.3300
36 C5a C 33.0400 -24.1500
37 C1b C 31.7800 -26.2500
38 C6a C 32.9700 -26.9500
39 O6a O 34.2300 -26.3200
40 O6a O 32.9700 -28.3500
41 N1b N 34.2300 -24.9200
42 O5a O 33.0400 -22.7500
43 C1c C 35.4200 -24.2200
44 C1c C 36.9600 -24.9200
45 C5a C 35.4200 -22.8200
46 O5a O 36.6100 -22.1200
47 N1b N 34.2300 -22.1200
48 C1b C 34.2300 -20.7200
49 C5a C 33.0400 -20.0200
50 O5a O 31.8500 -20.7200
51 N1b N 33.0400 -18.6200
52 C1c C 31.8500 -17.9200
53 C1b C 30.6600 -18.6200
54 C5a C 31.8500 -16.5200
55 C1b C 29.4700 -17.9200
56 C1b C 28.2800 -18.6200
57 N1a N 27.0900 -17.9200
58 O5a O 30.6600 -15.8200
59 N1b N 33.0400 -15.8200
60 C1c C 33.7400 -14.6300
61 C5a C 35.1400 -14.6300
62 N1b N 35.8400 -15.8200
63 C1b C 33.0400 -13.3700
64 C6a C 31.6400 -13.3700
65 O6a O 30.9400 -12.1800
66 O6a O 30.9400 -14.5600
67 O5a O 35.8400 -13.4400
68 C1c C 37.0300 -16.5200
69 C5a C 38.2200 -15.8200
70 C1a C 37.0300 -17.9200
71 N1b N 39.4100 -16.5200
72 O5a O 38.2200 -14.4200
73 C1c C 40.6000 -15.8200
74 C5a C 41.7900 -16.5200
75 C1b C 40.6000 -14.4200
76 C6a C 41.7900 -13.7200
77 O6a O 43.0500 -14.4200
78 O6a O 41.7900 -12.3200
79 N1b N 42.9800 -15.8200
80 O5a O 41.7900 -17.9200
81 C1b C 44.2400 -16.5200
82 C5a C 44.2400 -17.9200
83 N1b N 42.9800 -18.6200
84 O5a O 45.4300 -18.6200
85 C1c C 42.9800 -20.0200
86 C5a C 41.7900 -20.7200
87 C1b C 44.2400 -20.6500
88 O1a O 45.4300 -19.9500
89 O5a O 40.6000 -20.0200
90 N1b N 41.7900 -22.1200
91 C1c C 40.6000 -22.8200
92 C1c C 39.4100 -22.1200
93 C5a C 40.6000 -24.2200
94 N1b N 39.4100 -24.9200
95 O5a O 41.7900 -24.9200
96 C1c C 39.4100 -26.3200
97 C7a C 38.1500 -27.0200
98 C1b C 40.6000 -27.0200
99 O7a O 36.9600 -26.3200
100 O6a O 38.1500 -28.4200
101 C1a C 38.1500 -24.1500
102 C1b C 39.4100 -20.7200
103 C1a C 38.2200 -22.8200
104 C6a C 38.2200 -20.0200
105 O6a O 37.0300 -20.7200
106 O6a O 38.2200 -18.6200
107 C5a C 40.6000 -28.4200
108 O5a O 39.4100 -29.1200
109 C8y C 41.7900 -29.1200
110 C8x C 41.7900 -30.5200
111 C8x C 43.0500 -31.2200
112 C8x C 44.2400 -30.5200
113 C8x C 44.2400 -29.1200
114 C8y C 43.0500 -28.4200
115 N1a N 43.0500 -27.0200
BOND 118
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 6 7 1
7 7 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 10 12 2
12 11 13 1
13 13 14 1
14 14 15 1
15 14 16 2
16 15 17 1
17 17 18 1
18 17 19 1 #Down
19 19 20 1
20 20 21 1
21 20 22 2
22 18 23 1
23 23 24 1
24 18 25 2
25 13 26 1 #Down
26 26 27 1
27 27 28 1
28 28 29 1
29 29 30 1
30 30 31 1
31 27 31 2
32 28 32 2
33 32 33 1
34 33 34 2
35 34 35 1
36 29 35 2
37 24 36 1
38 24 37 1 #Down
39 37 38 1
40 38 39 1
41 38 40 2
42 36 41 1
43 36 42 2
44 43 41 1 #Down
45 43 44 1
46 43 45 1
47 45 46 2
48 45 47 1
49 47 48 1
50 48 49 1
51 49 50 2
52 49 51 1
53 51 52 1
54 52 53 1 #Up
55 52 54 1
56 53 55 1
57 55 56 1
58 56 57 1
59 54 58 2
60 54 59 1
61 59 60 1
62 60 61 1
63 61 62 1
64 60 63 1 #Up
65 63 64 1
66 64 65 1
67 64 66 2
68 61 67 2
69 62 68 1
70 68 69 1
71 68 70 1 #Up
72 69 71 1
73 69 72 2
74 71 73 1
75 73 74 1
76 73 75 1 #Up
77 75 76 1
78 76 77 1
79 76 78 2
80 74 79 1
81 74 80 2
82 79 81 1
83 81 82 1
84 82 83 1
85 82 84 2
86 83 85 1
87 85 86 1
88 85 87 1 #Down
89 87 88 1
90 86 89 2
91 86 90 1
92 90 91 1
93 91 92 1
94 91 93 1
95 93 94 1
96 93 95 2
97 94 96 1
98 96 97 1
99 96 98 1 #Up
100 97 99 1
101 97 100 2
102 99 44 1
103 44 101 1 #Up
104 92 102 1
105 92 103 1 #Down
106 102 104 1
107 104 105 1
108 104 106 2
109 98 107 1
110 107 108 2
111 107 109 1
112 109 110 2
113 110 111 1
114 111 112 2
115 112 113 1
116 113 114 2
117 109 114 1
118 114 115 1
|
|---|
