KEGG   DRUG: Lanoconazole
Entry
D01092                      Drug                                   

Name
Lanoconazole (JP18/INN);
Latoconazole;
Astat (TN)
Formula
C14H10ClN3S2
Exact mass
319.0005
Mol weight
319.8323
Structure
Simcomp
Class
Antifungal
 DG01883  Imidazole antifungal
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
Remark
Therapeutic category: 2655
Product: D01092<JP>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Imidazole derivative
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Structure map
map07026  Antifungal agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   265  Antiparasitic dermatosis agents
    2655  Imidazoles
     D01092  Lanoconazole (JP18/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  58 Ringworm drugs
   D01092  Lanoconazole (JP18/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Lanoconazole
    D01092  Lanoconazole (JP18/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Lanoconazole
    D01092  Lanoconazole (JP18/INN)
Antimicrobials [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Imidazole
    D01092  Lanoconazole (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01092  Lanoconazole
  D01092  Lanoconazole cutaneous solution
  D01092  Lanoconazole ointment
  D01092  Lanoconazole cream
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01092
Rx-to-OTC switch list in Japan [br08314.html]
 D01092
Other DBs
CAS: 101530-10-3
PubChem: 7848155
ChEBI: 31761
ChEMBL: CHEMBL1555126
LigandBox: D01092
NIKKAJI: J421.471D
LinkDB
KCF data

ATOM        20
            1   C8x C     7.9800  -18.0600
            2   C8x C     7.9800  -19.4600
            3   C8x C     9.1924  -20.1600
            4   C8y C    10.4049  -19.4600
            5   C8y C    10.4049  -18.0600
            6   C8x C     9.1924  -17.3600
            7   X   Cl   11.6173  -20.1600
            8   C1y C    11.6173  -17.3600
            9   C1x C    11.6173  -15.9600
            10  S2x S    12.9488  -17.7926
            11  C2y C    13.7717  -16.6600
            12  S2x S    12.9488  -15.5274
            13  C2c C    15.1900  -16.6600
            14  C3b C    15.8900  -17.8724
            15  N4y N    15.8900  -15.4476
            16  C8x C    17.2900  -15.4476
            17  N5x N    17.7226  -14.1161
            18  C8x C    16.5900  -13.2932
            19  C8x C    15.4574  -14.1161
            20  N3a N    16.5900  -19.0849
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 1
            11   10  11 1
            12   11  12 1
            13    9  12 1
            14   11  13 2
            15   13  14 1
            16   13  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   15  19 1
            22   14  20 3

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