KEGG   DRUG: Trospium chloride
Entry
D01103                      Drug                                   
Name
Trospium chloride (JAN/USP/INN);
Spasmex (TN);
Spasmoplex (TN)
Product
  Generic
TROSPIUM CHLORIDE (A-S Medication Solutions), TROSPIUM CHLORIDE (Actavis Pharma), TROSPIUM CHLORIDE (Bluepoint Laboratories), TROSPIUM CHLORIDE (Bryant Ranch Prepack), TROSPIUM CHLORIDE (Bryant Ranch Prepack), TROSPIUM CHLORIDE (Bryant Ranch Prepack), TROSPIUM CHLORIDE (CIPLA USA INC.,), TROSPIUM CHLORIDE (Exelan Pharmaceuticals), TROSPIUM CHLORIDE (Glenmark Pharmaceuticals), TROSPIUM CHLORIDE (Golden State Medical Supply), TROSPIUM CHLORIDE (Granules Pharmaceuticals), TROSPIUM CHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), TROSPIUM CHLORIDE (Major Pharmaceuticals), TROSPIUM CHLORIDE (Padagis US LLC), TROSPIUM CHLORIDE (Padagis US LLC), TROSPIUM CHLORIDE (Proficient Rx LP), TROSPIUM CHLORIDE (Slate Run Pharmaceuticals), TROSPIUM CHLORIDE (Zameer Pharmaceuticals LLC), TROSPIUM CHLORIDE ER (35573)
Formula
C25H30NO3. Cl
Exact mass
427.1914
Mol weight
427.9636
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
ATC code: G04BD09
Product: D01103<US>
Efficacy
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Comment
Treatment of urinary incontinence
Target
CHRM2 [HSA:1129] [KO:K04130]
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Drugs for urinary frequency and incontinence
     G04BD09 Trospium
      D01103  Trospium chloride (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Cholinergic Muscarinic Antagonists
    Trospium Chloride
     D01103  Trospium chloride (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   D01103  Trospium chloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D01103  Trospium chloride (JAN/USP/INN) <US>
    CHRM3
     D01103  Trospium chloride (JAN/USP/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01103
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01103
Other DBs
CAS: 10405-02-4
PubChem: 7848166
ChEBI: 32270
LigandBox: D01103
NIKKAJI: J252.925D
LinkDB
KCF data

ATOM        30
            1   X   Cl   11.7779  -16.5523 #-
            2   N2y N    14.0700  -15.8200 #+
            3   C1x C    15.1900  -14.9800
            4   C1x C    14.7700  -13.6500
            5   C1x C    13.3700  -13.6500
            6   C1x C    12.9500  -15.0500
            7   O7a O    18.1300  -19.5300
            8   C1y C    17.4300  -18.3400
            9   C1x C    16.3800  -16.8000
            10  C1x C    16.3800  -17.8500
            11  C1y C    14.9100  -16.8000
            12  C1y C    14.8400  -17.8500
            13  C1x C    13.8600  -17.3600
            14  C1x C    13.3700  -18.4800
            15  C7a C    19.5300  -19.5300
            16  O6a O    20.2300  -20.7424
            17  C1d C    20.2300  -18.3176
            18  C8y C    21.8398  -18.3176
            19  C8y C    19.5396  -17.1221
            20  O1a O    20.9300  -17.1051
            21  C8x C    20.2251  -15.9347
            22  C8x C    19.5250  -14.7223
            23  C8x C    18.1250  -14.7224
            24  C8x C    17.4396  -15.9097
            25  C8x C    18.1396  -17.1221
            26  C8x C    22.5497  -19.5468
            27  C8x C    23.9497  -19.5466
            28  C8x C    24.6496  -18.3341
            29  C8x C    23.9397  -17.1049
            30  C8x C    22.5397  -17.1051
BOND        33
            1     3   4 1
            2     8   9 1
            3     8  10 1
            4     9  11 1
            5    10  12 1
            6    11   2 1
            7    11  13 1
            8    12  14 1
            9    12   2 1
            10   13  14 1
            11    8   7 1 #Down
            12    4   5 1
            13    5   6 1
            14    6   2 1
            15    2   3 1
            16    7  15 1
            17   15  16 2
            18   15  17 1
            19   17  18 1
            20   17  19 1
            21   17  20 1
            22   19  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   19  25 1
            28   18  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   18  30 1

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