Entry |
|
Name |
Thiethylperazine maleate (JAN/USP); Norzine (TN) |
Formula |
C22H29N3S2. (C4H4O4)2
|
Exact mass |
631.2022
|
Mol weight |
631.76
|
Structure |

|
Simcomp |
|
Class |
Neuropsychiatric agent
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
|
Remark |
|
Efficacy |
Anti-emetic, Antipsychotic, Dopamine D2 receptor antagonist |
Comment |
Phenothiazine derivative
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Interaction |
|
Structure map |
map07029 | Antipsychotics - phenothiazines |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AD Phenothiazine derivatives
R06AD03 Thiethylperazine
D01130 Thiethylperazine maleate (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG01102 Thiethylperazine
D01130 Thiethylperazine maleate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D01130 Thiethylperazine maleate (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG01102 Thiethylperazine
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 43
1 C6a C 40.5832 -20.1140
2 C2b C 39.9323 -18.9911
3 O6a O 39.9382 -21.3127
4 O6a O 41.8853 -20.1079
5 C2b C 38.2335 -18.9970
6 C6a C 37.5885 -20.1258
7 O6a O 36.2863 -20.1258
8 O6a O 38.2454 -21.2486
9 C8y C 23.6600 -21.2800
10 N1y N 24.8500 -20.5100
11 C8y C 23.6600 -22.6100
12 C8x C 22.4000 -20.5100
13 C8y C 26.0400 -21.2800
14 S2x S 24.8500 -23.3800
15 C8x C 22.4000 -23.3800
16 C8x C 21.2100 -21.2800
17 C8y C 26.0400 -22.6100
18 C8x C 27.3000 -20.5100
19 C8x C 21.2100 -22.6100
20 C8x C 27.3000 -23.3800
21 C8y C 28.4900 -21.2800
22 C8x C 28.4900 -22.6100
23 S2a S 29.6800 -20.5800
24 C1b C 30.9400 -21.2800
25 C1a C 32.1300 -20.5800
26 C1b C 24.8500 -19.1100
27 C1b C 26.1100 -18.4100
28 C1b C 27.3000 -19.1100
29 N1y N 28.4900 -18.4100
30 C1x C 29.6800 -19.0400
31 C1x C 30.8700 -18.3400
32 N1y N 30.8700 -16.9400
33 C1x C 29.6800 -16.3100
34 C1x C 28.4900 -17.0100
35 C1a C 32.1300 -16.2400
36 C6a C 40.5832 -20.1140
37 C2b C 39.9323 -18.9911
38 C2b C 38.2335 -18.9970
39 C6a C 37.5885 -20.1258
40 O6a O 36.2863 -20.1258
41 O6a O 38.2454 -21.2486
42 O6a O 39.9382 -21.3127
43 O6a O 41.8853 -20.1079
BOND 44
1 9 10 1
2 9 11 2
3 9 12 1
4 10 13 1
5 11 14 1
6 11 15 1
7 12 16 2
8 13 17 2
9 13 18 1
10 15 19 2
11 17 20 1
12 18 21 2
13 20 22 2
14 14 17 1
15 16 19 1
16 21 22 1
17 21 23 1
18 23 24 1
19 24 25 1
20 10 26 1
21 26 27 1
22 27 28 1
23 28 29 1
24 29 30 1
25 30 31 1
26 31 32 1
27 32 33 1
28 33 34 1
29 29 34 1
30 32 35 1
31 6 7 1
32 6 8 2
33 1 2 1
34 1 3 1
35 1 4 2
36 2 5 2
37 5 6 1
38 39 40 1
39 39 41 2
40 36 37 1
41 36 42 1
42 36 43 2
43 37 38 2
44 38 39 1
BRACKET 1 34.5800 -21.9800 34.5800 -18.4100
1 42.9100 -18.4100 42.9100 -21.9800
1 2
ORIGINAL 1 1 2 5 6 7 8 3 4
REPEAT 1 36 37 38 39 40 41 42 43
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