KEGG   DRUG: Tranexamic acidHelp
Entry
D01136                      Drug                                   

Name
Tranexamic acid (JP17/USAN/INN);
Cyklokapron (TN);
Rikavarin (TN);
Transamin (TN)
Product
  Generic
TRANEXAMIC ACID (Acella Pharmaceuticals), TRANEXAMIC ACID (Actavis Pharma), TRANEXAMIC ACID (Akorn), TRANEXAMIC ACID (Akorn), TRANEXAMIC ACID (Akorn), TRANEXAMIC ACID (Alvogen), TRANEXAMIC ACID (American Health Packaging), TRANEXAMIC ACID (American Regent), TRANEXAMIC ACID (Amneal Biosciences LLC), TRANEXAMIC ACID (Amring Pharmaceuticals), TRANEXAMIC ACID (Apotex Corp.), TRANEXAMIC ACID (Athenex Pharmaceutical Division), TRANEXAMIC ACID (AuroMedics Pharma LLC), TRANEXAMIC ACID (Cadila Healthcare Limited), TRANEXAMIC ACID (Fresenius Kabi USA), TRANEXAMIC ACID (Gland Pharma Limited), TRANEXAMIC ACID (Heritage Pharmaceuticals), TRANEXAMIC ACID (Heritage Pharmaceuticals), TRANEXAMIC ACID (Micro Labs Limited), TRANEXAMIC ACID (Mylan Institutional LLC), TRANEXAMIC ACID (Nexus Pharmaceuticals), TRANEXAMIC ACID (Prasco Laboratories), TRANEXAMIC ACID (Prasco Laboratories), TRANEXAMIC ACID (Virtus Pharmaceuticals), TRANEXAMIC ACID (X-GEN Pharmaceuticals), TRANEXAMIC ACID (X-GEN Pharmaceuticals), TRANEXAMIC ACID (Zydus Pharmaceuticals (USA))
Formula
C8H15NO2
Exact mass
157.1103
Mol weight
157.2102
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG02012  Antifibrinolytics
  DG01540  Plasmin inhibitor
 DG02016  Hemostatics
  DG02012  Antifibrinolytics
   DG01540  Plasmin inhibitor
Anti-allergic agent
 DG01540  Plasmin inhibitor
Remark
Same as: C12535
Therapeutic category: 3327 4490
ATC code: B02AA02
Product: D01136<JP/US>
Efficacy
Antifibrinolytic, Anti-inflammatory, Plasmin inhibitor
  Disease
Hemophilia [DS:H00219]
Target
PLG [HSA:5340] [KO:K01315]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02A ANTIFIBRINOLYTICS
    B02AA Amino acids
     B02AA02 Tranexamic acid
      D01136  Tranexamic acid (JP17/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Hemostasis Agents
   Tranexamic acid
    D01136  Tranexamic acid (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   332  Hemostatics
    3327  Antiplasmins
     D01136  Tranexamic acid (JP17/USAN/INN)
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01136  Tranexamic acid (JP17/USAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Nourishing tonics and health supplements
  38 Vitamin C based drugs
   D01136  Tranexamic acid (JP17/USAN/INN)
 Agents for dental and stomatological use
  73 Stomatologic and laryngologic remedies (incl. toche without claims for cough and phlegm)
   D01136  Tranexamic acid (JP17/USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Tranexamic acid
    D01136  Tranexamic acid (JP17/USAN/INN)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Tranexamic acid
    D01136  Tranexamic acid (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Immune system
   Complement and coagulation
    PLG
     D01136  Tranexamic acid (JP17/USAN/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01136  Tranexamic acid
  D01136  Tranexamic acid tablets
  D01136  Tranexamic acid capsules
  D01136  Tranexamic acid injection
Rx-to-OTC switch list in Japan [br08314.html]
 D01136
BRITE hierarchy
Other DBs
CAS: 1197-18-8
PubChem: 7848199
ChEBI: 48669
ChEMBL: CHEMBL877
DrugBank: DB00302
PDB-CCD: AMH[PDBj]
LigandBox: D01136
NIKKAJI: J3.664A
LinkDB All DBs
KCF data Show

ATOM        11
            1   C1x C    23.7617  -17.2548
            2   C1x C    23.7617  -18.6550
            3   C1y C    24.9772  -19.3552
            4   C1x C    26.1856  -18.6550
            5   C1x C    26.1856  -17.2548
            6   C1y C    24.9772  -16.5547
            7   C6a C    24.9789  -15.1545
            8   O6a O    26.1924  -14.4560
            9   O6a O    23.7673  -14.4529
            10  C1b C    24.9789  -20.7554
            11  N1a N    26.1924  -21.4540
BOND        11
            1     5   6 1
            2     6   1 1
            3     6   7 1
            4     1   2 1
            5     7   8 1
            6     2   3 1
            7     7   9 2
            8     3   4 1
            9     3  10 1 #Down
            10    4   5 1
            11   10  11 1

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