KEGG   DRUG: Prulifloxacin
Entry
D01144                      Drug                                   

Name
Prulifloxacin (JAN/INN);
PUFX;
Sword (TN)
Formula
C21H20FN3O6S
Exact mass
461.1057
Mol weight
461.4634
Structure
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
Therapeutic category: 6241
ATC code: J01MA17
Product: D01144<JP>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Active form of prodrug: Ulifloxacin [CPD:C14492]
Target
DNA gyrase [KO:K02469 K02470]
Interaction
Structure map
map07014  Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA17 Prulifloxacin
      D01144  Prulifloxacin (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D01144  Prulifloxacin (JAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01144
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01144
Prodrugs [br08324.html]
 D01144
Other DBs
CAS: 123447-62-1
PubChem: 7848207
ChEBI: 32071
LigandBox: D01144
NIKKAJI: J727.137I
LinkDB
KCF data

ATOM        32
            1   C8y C    26.6700  -19.5300
            2   C8y C    27.8600  -20.2300
            3   C8y C    25.4100  -20.2300
            4   C8y C    25.4100  -21.6300
            5   C8x C    24.2200  -22.4000
            6   C8y C    23.0300  -21.6300
            7   C8y C    23.0300  -20.2300
            8   C8x C    24.2200  -19.5300
            9   N1y N    21.7700  -22.4000
            10  C1x C    21.7700  -23.8000
            11  C1x C    20.5800  -24.5000
            12  C1x C    20.5800  -21.6300
            13  C1x C    19.3900  -22.4000
            14  N1y N    19.3900  -23.7300
            15  C1b C    18.1300  -24.4300
            16  C8y C    16.9400  -23.8000
            17  X   F    21.7700  -19.5300
            18  O5x O    26.6700  -18.1300
            19  N4y N    26.6700  -22.4000
            20  C8y C    27.8600  -21.6300
            21  S2x S    28.5600  -22.8900
            22  C1y C    27.3700  -23.5900
            23  C6a C    29.0500  -19.5300
            24  O6a O    29.0500  -18.1300
            25  O6a O    30.3100  -20.3000
            26  C1a C    27.0187  -24.9452
            27  O7x O    16.7427  -22.4140
            28  C8y C    15.3635  -22.1733
            29  O7x O    14.7084  -23.4106
            30  C8y C    15.6828  -24.4160
            31  O6a O    14.7478  -20.9168
            32  C1a C    15.4397  -25.8092
BOND        36
            1     5   6 2
            2    13  14 1
            3    14  15 1
            4    15  16 1
            5     6   7 1
            6     7   8 2
            7     8   3 1
            8     3   1 1
            9     6   9 1
            10    1   2 1
            11    2  20 2
            12    7  17 1
            13   19   4 1
            14    1  18 2
            15    9  10 1
            16   10  11 1
            17   11  14 1
            18   13  12 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  19 1
            23   12   9 1
            24    2  23 1
            25    3   4 2
            26   23  24 2
            27    4   5 1
            28   23  25 1
            29   22  26 1 #Down
            30   16  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   16  30 2
            35   28  31 2
            36   30  32 1

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