KEGG   DRUG: Olopatadine hydrochloride
Entry
D01192                      Drug                                   
Name
Olopatadine hydrochloride (JP18/USP);
Allelock (TN);
Patanol (TN);
Opatanol (TN)
Product
  Generic
Formula
C21H23NO3. HCl
Exact mass
373.1445
Mol weight
373.8732
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Therapeutic category: 1319 4490
ATC code: R01AC08 S01GX09
Chemical structure group: DG01039
Product (DG01039): D01192<JP/US>
Efficacy
Antiallergic, H1 receptor antagonist
  Disease
Seasonal allergic rhinitis [DS:H01360]
Comment
Loratadine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC08 Olopatadine
      D01192  Olopatadine hydrochloride (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX09 Olopatadine
      D01192  Olopatadine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Antihistamine
    Olopatadine
     D01192  Olopatadine hydrochloride (JP18/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Mildly/Non-sedating
    Olopatadine
     D01192  Olopatadine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01192  Olopatadine hydrochloride (JP18/USP)
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01192  Olopatadine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01039  Olopatadine
     D01192  Olopatadine hydrochloride
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01192  Olopatadine hydrochloride
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D01192  Olopatadine hydrochloride
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01192  Olopatadine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01192  Olopatadine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01192  Olopatadine hydrochloride
  D01192  Olopatadine hydrochloride tablets
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01192
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01192
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01192
Rx-to-OTC switch list in the USA [br08315.html]
 D01192
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01039  Olopatadine
Other DBs
CAS: 140462-76-6
PubChem: 7848255
ChEBI: 31933
LigandBox: D01192
NIKKAJI: J508.357E
LinkDB
KCF data

ATOM        26
            1   X   Cl   25.5488  -17.6013
            2   O2x O    18.4771  -20.2698
            3   C8y C    17.6355  -19.1476
            4   C8y C    17.9161  -17.7450
            5   C2y C    19.1785  -17.1839
            6   C1x C    19.8798  -20.2698
            7   C8y C    20.4409  -17.8151
            8   C8y C    20.7214  -19.2178
            9   C8x C    16.9341  -16.7630
            10  C8y C    15.6016  -17.1839
            11  C8x C    15.2509  -18.5165
            12  C8x C    16.2328  -19.4983
            13  C8x C    22.1241  -19.6385
            14  C8x C    23.1060  -18.6567
            15  C8x C    22.8254  -17.3241
            16  C8x C    21.4929  -16.9034
            17  C2b C    19.1785  -15.7812
            18  C1b C    14.5495  -16.2021
            19  C6a C    13.2170  -16.6228
            20  O6a O    12.2351  -15.6410
            21  O6a O    12.8664  -17.9554
            22  C1b C    17.9865  -15.0638
            23  C1b C    17.9865  -13.6646
            24  N1c N    16.7747  -12.9650
            25  C1a C    15.5841  -13.6522
            26  C1a C    16.7746  -11.5441
BOND        27
            1     4   5 1
            2     2   6 1
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13    8  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17    7  16 2
            18    5  17 2
            19   10  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23   17  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 1

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