KEGG   DRUG: DifluprednateHelp
Entry
D01266                      Drug                                   

Name
Difluprednate (JAN/USAN/INN);
Durezol (TN)
Product
Formula
C27H34F2O7
Exact mass
508.2273
Mol weight
508.5515
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C12695
Therapeutic category: 2646
ATC code: D07AC19
Product: D01266<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC19 Difluprednate
      D01266  Difluprednate (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Difluprednate
    D01266  Difluprednate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01266  Difluprednate (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01266  Difluprednate (JAN/USAN/INN) <JP/US>
Topical steroids potency [br08317.html]
 Classification in Japan
  D01266
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01266
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01266
BRITE hierarchy
Other DBs
CAS: 23674-86-4
PubChem: 7848329
ChEBI: 31485
ChEMBL: CHEMBL1201749 CHEMBL1881053
LigandBox: D01266
NIKKAJI: J15.820H
LinkDB All DBs
KCF data Show

ATOM        36
            1   C1z C    23.2566  -15.7189
            2   C1z C    22.0669  -16.3838
            3   C1x C    24.4349  -16.4188
            4   C5a C    23.2800  -14.0508
            5   O7a O    24.4523  -15.0131
            6   C1y C    22.0435  -17.7543
            7   C1x C    20.8770  -15.6956
            8   C1a C    22.0552  -14.9899
            9   C1x C    24.4173  -17.7894
            10  C1b C    22.0900  -13.3392
            11  O5a O    24.4930  -13.3742
            12  C7a C    25.8345  -15.0131
            13  C1y C    20.8536  -18.4252
            14  C1y C    19.6930  -16.3605
            15  O7a O    20.8829  -14.0274
            16  C1b C    26.5170  -13.8174
            17  O6a O    26.5286  -16.2147
            18  C1z C    19.6813  -17.7369
            19  C1x C    20.8536  -19.7900
            20  O1a O    18.5032  -15.6839
            21  C7a C    19.6813  -13.3334
            22  C1b C    27.8992  -13.8174
            23  C1z C    18.4916  -18.4135
            24  X   F    19.6696  -19.0958
            25  C1y C    19.6696  -20.4723
            26  C1a C    18.4857  -14.0274
            27  O6a O    19.6756  -11.9453
            28  C2y C    18.4857  -19.7840
            29  C2x C    17.3076  -17.7310
            30  C2x C    17.3076  -20.4665
            31  C2x C    16.1293  -18.4135
            32  C5x C    16.1293  -19.7840
            33  O5x O    14.9396  -20.4606
            34  X   F    19.6669  -21.8677
            35  C1a C    18.4784  -17.0159
            36  C1a C    28.5969  -12.6089
BOND        39
            1     1   4 1 #Up
            2     1   5 1 #Down
            3     2   6 1
            4     2   7 1
            5     2   8 1 #Up
            6     3   9 1
            7     4  10 1
            8     4  11 2
            9     5  12 1
            10    6  13 1
            11    7  14 1
            12   10  15 1
            13   12  16 1
            14   12  17 2
            15   13  18 1
            16   13  19 1
            17   14  20 1 #Up
            18   15  21 1
            19   16  22 1
            20   18  23 1
            21   18  24 1 #Down
            22   19  25 1
            23   21  26 1
            24   21  27 2
            25   23  28 1
            26   23  29 1
            27   28  30 2
            28   29  31 2
            29   30  32 1
            30   32  33 2
            31    6   9 1
            32   14  18 1
            33   25  28 1
            34   31  32 1
            35   25  34 1 #Down
            36    1   2 1
            37   23  35 1 #Up
            38    1   3 1
            39   22  36 1

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