KEGG   DRUG: Tiaprofenic acidHelp
Entry
D01325                      Drug                                   

Name
Tiaprofenic acid (JAN/INN);
Surgam (TN)
Formula
C14H12O3S
Exact mass
260.0507
Mol weight
260.3083
Structure
Mol fileKCF fileDB search
Class
Anti-inflammatory
 DG01908  Antiinflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01908  Antiinflammatory drug, propionic acid derivatives
Remark
Therapeutic category: 1149
ATC code: M01AE11
Product: D01325<JP>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Drug interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE11 Tiaprofenic acid
      D01325  Tiaprofenic acid (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01325  Tiaprofenic acid (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01325  Tiaprofenic acid (JAN/INN) <JP>
    PTGS2 (COX2)
     D01325  Tiaprofenic acid (JAN/INN) <JP>
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D01325
 Anesthetics, analgesics and anti-inflammatory drugs
  D01325
BRITE hierarchy
Other DBs
CAS: 33005-95-7
PubChem: 7848388
ChEBI: 32221
ChEMBL: CHEMBL365795
LigandBox: D01325
NIKKAJI: J3.176C
LinkDB All DBs
KCF data Show

ATOM        18
            1   C8y C    26.6788  -17.9072
            2   C1c C    27.8898  -17.2080
            3   C6a C    29.1008  -17.9072
            4   C1a C    27.8898  -15.8098
            5   O6a O    29.1008  -19.3054
            6   O6a O    30.3116  -17.2080
            7   S2x S    25.5444  -17.0823
            8   C8y C    24.4031  -17.9072
            9   C8x C    24.8382  -19.2432
            10  C8x C    26.2436  -19.2432
            11  C8x C    19.5607  -17.9053
            12  C8x C    19.5607  -19.3036
            13  C8x C    20.7746  -20.0027
            14  C8x C    21.9813  -19.3036
            15  C8y C    21.9813  -17.9053
            16  C8x C    20.7746  -17.2062
            17  C5a C    23.1928  -17.2072
            18  O5a O    23.1938  -15.8089
BOND        19
            1     9  10 1
            2    10   1 2
            3     1   7 1
            4     2   3 1
            5     3   6 1
            6     8   9 2
            7     1   2 1
            8     2   4 1
            9    11  12 2
            10   12  13 1
            11   13  14 2
            12   14  15 1
            13   15  16 2
            14   16  11 1
            15    3   5 2
            16   15  17 1
            17   17   8 1
            18    7   8 1
            19   17  18 2

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