KEGG   DRUG: Diflorasone diacetateHelp
Entry
D01327                      Drug                                   

Name
Diflorasone diacetate (JP17/USP);
Florone (TN);
Psorcon (TN)
Product
  Generic
Formula
C26H32F2O7
Exact mass
494.2116
Mol weight
494.5249
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: D07AC10
Chemical structure group: DG00418
Product (DG00418): D01327<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC10 Diflorasone
      D01327  Diflorasone diacetate (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Diflorasone
   D01327  Diflorasone diacetate (JP17/USP)
  Diflorasone
   D01327  Diflorasone diacetate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01327  Diflorasone diacetate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01327  Diflorasone diacetate (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01327  Diflorasone diacetate
Topical steroids potency [br08317.html]
 Classification in the USA
  D01327
 Classification in Japan
  D01327
BRITE hierarchy
Other DBs
CAS: 33564-31-7
PubChem: 7848390
ChEBI: 31483
ChEMBL: CHEMBL1200545
DrugBank: DB00223
LigandBox: D01327
NIKKAJI: J17.484J
LinkDB All DBs
KCF data Show

ATOM        35
            1   C1z C    32.0564  -14.3706
            2   C1z C    30.9003  -15.0167
            3   C1y C    33.2015  -15.0507
            4   C5a C    32.0791  -12.5453
            5   O7a O    34.3069  -13.4125
            6   C1y C    30.8775  -16.3486
            7   C1x C    29.7439  -14.3479
            8   C1a C    30.8889  -13.6621
            9   C1x C    33.1844  -16.3826
            10  C1b C    30.9227  -11.8538
            11  O5a O    33.2580  -11.8878
            12  C7a C    35.6502  -13.4125
            13  C1y C    29.7211  -17.0006
            14  C1y C    28.5932  -14.9941
            15  O7a O    29.7496  -12.5227
            16  C1a C    36.3134  -12.2505
            17  O6a O    36.3248  -14.5802
            18  C1z C    28.5818  -16.3317
            19  C1x C    29.7211  -18.3268
            20  O1a O    27.4370  -14.3365
            21  C7a C    28.5818  -11.8482
            22  C1z C    27.4257  -16.9892
            23  X   F    28.5706  -17.6523
            24  C1y C    28.5706  -18.9900
            25  C1a C    27.4199  -12.5227
            26  O6a O    28.5763  -10.4991
            27  C2y C    27.4199  -18.3211
            28  C2x C    26.2751  -16.3260
            29  C1a C    27.4144  -15.6571
            30  C2x C    26.2751  -18.9844
            31  C2x C    25.1300  -16.9892
            32  C5x C    25.1300  -18.3211
            33  O5x O    23.9738  -18.9786
            34  C1a C    34.5562  -15.0488
            35  X   F    28.5635  -20.3431
BOND        38
            1     1   4 1 #Up
            2     1   5 1 #Down
            3     2   6 1
            4     2   7 1
            5     2   8 1 #Up
            6     3   9 1
            7     4  10 1
            8     4  11 2
            9     5  12 1
            10    6  13 1
            11    7  14 1
            12   10  15 1
            13   12  16 1
            14   12  17 2
            15   13  18 1
            16   13  19 1
            17   14  20 1 #Up
            18   15  21 1
            19   18  22 1
            20   18  23 1 #Down
            21   19  24 1
            22   21  25 1
            23   21  26 2
            24   22  27 1
            25   22  28 1
            26   22  29 1 #Up
            27   27  30 2
            28   28  31 2
            29   30  32 1
            30   32  33 2
            31    6   9 1
            32   14  18 1
            33   24  27 1
            34   31  32 1
            35    3  34 1 #Up
            36    1   2 1
            37    1   3 1
            38   24  35 1 #Down

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