| Entry |
|
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| Name |
Fluorometholone (JP18/USP/INN);
NSC 33001;
Fluor-op (TN);
Fml (TN);
Oxylone (TN) |
|---|
| Product |
|
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| Generic |
|
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| Formula |
C22H29FO4
|
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| Exact mass |
376.2050
|
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| Mol weight |
376.46
|
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| Structure |
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| Simcomp |
|
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| Class |
|
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| Remark |
| Therapeutic category: | 1315 |
| Product (DG00294): | D01367<JP/US> D04221<US> |
|
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA06 Fluorometholone
D01367 Fluorometholone (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB06 Fluorometholone
D01367 Fluorometholone (JP18/USP/INN) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB04 Fluorometholone
D01367 Fluorometholone (JP18/USP/INN) <JP/US>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA01 Fluorometholone
D01367 Fluorometholone (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA07 Fluorometholone
D01367 Fluorometholone (JP18/USP/INN) <JP/US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB05 Fluorometholone
D01367 Fluorometholone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Ophthalmic Agents
Ophthalmic Anti-inflammatories
Glucocorticoids, Ophthalmic
Fluorometholone
D01367 Fluorometholone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1315 Ophthalmic cortisones
D01367 Fluorometholone (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00294 Fluorometholone
D01367 Fluorometholone
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01367 Fluorometholone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01367 Fluorometholone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01367 Fluorometholone
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00294 Fluorometholone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 27
1 C2x C 4.2000 -16.3800
2 C5x C 4.2000 -17.7800
3 C2x C 5.4124 -18.4800
4 C2y C 6.6249 -17.7800
5 C1z C 6.6249 -16.3800
6 C2x C 5.4124 -15.6800
7 C1y C 7.8373 -18.4800
8 C1x C 9.0497 -17.7800
9 C1y C 9.0497 -16.3800
10 C1z C 7.8373 -15.6800
11 C1y C 10.2622 -15.6800
12 C1z C 10.2622 -14.2800
13 C1x C 9.0497 -13.5800
14 C1y C 7.8373 -14.2800
15 C1x C 12.6870 -15.6800
16 C1x C 12.6870 -14.2800
17 C1z C 11.4746 -13.5800
18 C5a C 11.4746 -12.1800
19 C1a C 10.2622 -12.8800
20 O1a O 6.6269 -13.5812
21 C1a C 6.6249 -14.9800
22 O1a O 12.6870 -12.8800
23 C1a C 7.8373 -19.8800
24 X F 7.8373 -17.0800
25 O5x O 2.9876 -18.4800
26 C1a C 12.6911 -11.4777
27 O5a O 10.2662 -11.4823
BOND 30
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 17 18 1 #Up
22 12 19 1 #Up
23 14 20 1 #Up
24 5 21 1 #Up
25 17 22 1 #Down
26 7 23 1 #Down
27 10 24 1 #Down
28 2 25 2
29 18 26 1
30 18 27 2
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