KEGG   DRUG: AmcinonideHelp
Entry
D01387                      Drug                                   

Name
Amcinonide (JAN/USP/INN);
Cyclocort (TN)
Product
  Generic
Formula
C28H35FO7
Exact mass
502.2367
Mol weight
502.5717
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: D07AC11
Product: D01387<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC11 Amcinonide
      D01387  Amcinonide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Amcinonide
   D01387  Amcinonide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01387  Amcinonide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01387  Amcinonide (JAN/USP/INN) <JP/US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D01387
 Classification in Japan
  D01387
BRITE hierarchy
Other DBs
CAS: 51022-69-6
PubChem: 7848450
ChEBI: 31199
ChEMBL: CHEMBL1200732
DrugBank: DB00288
LigandBox: D01387
NIKKAJI: J3.189E
LinkDB All DBs
KCF data Show

ATOM        36
            1   C2x C    18.6900  -29.1900
            2   C5x C    18.6900  -30.5200
            3   C2x C    19.8800  -31.2200
            4   C2y C    21.0700  -30.5200
            5   C1z C    21.0700  -29.1900
            6   C2x C    19.8800  -28.4900
            7   C1x C    22.2600  -31.2200
            8   C1x C    23.4500  -30.5200
            9   C1y C    23.4500  -29.1900
            10  C1z C    22.2600  -28.4900
            11  C1y C    24.5000  -28.4900
            12  C1z C    24.5000  -27.1600
            13  C1x C    23.4500  -26.4600
            14  C1y C    22.2600  -27.1600
            15  C1x C    26.8800  -28.4900
            16  C1y C    26.8800  -27.1600
            17  C1z C    25.6900  -26.4600
            18  O5x O    17.5700  -31.2200
            19  C1a C    21.0700  -27.7900
            20  X   F    22.2600  -29.8200
            21  O1a O    21.0700  -26.4600
            22  C1a C    24.5000  -25.7600
            23  C5a C    25.6900  -24.8500
            24  O2x O    27.0900  -25.5500
            25  O5a O    26.8800  -24.2200
            26  C1b C    24.5000  -24.2200
            27  O7a O    23.4500  -24.8500
            28  O2x O    28.2800  -27.1600
            29  C1z C    28.4900  -25.5500
            30  C7a C    22.2600  -24.1500
            31  C1a C    21.0700  -24.8500
            32  O6a O    22.2600  -22.7500
            33  C1x C    28.4900  -24.1500
            34  C1x C    29.8200  -25.9700
            35  C1x C    30.6600  -24.8500
            36  C1x C    29.8200  -23.7300
BOND        41
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Up
            27   17  24 1 #Down
            28   23  25 2
            29   23  26 1
            30   26  27 1
            31   16  28 1 #Down
            32   24  29 1
            33   29  28 1
            34   27  30 1
            35   30  31 1
            36   30  32 2
            37   33  29 1
            38   29  34 1
            39   34  35 1
            40   35  36 1
            41   33  36 1

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