| Entry |
|
|---|
| Name |
Flurbiprofen axetil (JAN);
FP 83;
Ropion (TN) |
|---|
| Formula |
C19H19FO4
|
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| Exact mass |
330.1267
|
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| Mol weight |
330.35
|
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| Structure |
|
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
| Therapeutic category: | 1149 |
| Product (DG00755): | D00330<JP/US> D01475<JP> D02290<US> |
|
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| Efficacy |
Analgesic, COX inhibitor |
|---|
| Comment |
Propionic acid derivative
Active form of prodrug: Flurbiprofen [DR: D00330]
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE09 Flurbiprofen
D01475 Flurbiprofen axetil (JAN) <JP>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA19 Flurbiprofen
D01475 Flurbiprofen axetil (JAN) <JP>
R RESPIRATORY SYSTEM
R02 THROAT PREPARATIONS
R02A THROAT PREPARATIONS
R02AX Other throat preparations
R02AX01 Flurbiprofen
D01475 Flurbiprofen axetil (JAN) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC04 Flurbiprofen
D01475 Flurbiprofen axetil (JAN) <JP>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Flurbiprofen
D01475 Flurbiprofen axetil (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D01475 Flurbiprofen axetil (JAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00755 Flurbiprofen
D01475 Flurbiprofen axetil
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00755 Flurbiprofen
D01475 Flurbiprofen axetil
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D01475 Flurbiprofen axetil
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D01475 Flurbiprofen axetil (JAN) <JP>
PTGS2 (COX2)
D01475 Flurbiprofen axetil (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01475
Prodrugs [br08324.html]
D01475
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00755 Flurbiprofen
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00755 Flurbiprofen
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 24
1 C8x C 10.3600 -10.3600
2 C8y C 10.3600 -8.9600
3 C8x C 9.1000 -8.2600
4 C8x C 7.9100 -8.9600
5 C8x C 7.9100 -10.3600
6 C8x C 9.1000 -11.0600
7 C8y C 11.5500 -8.2600
8 C8y C 12.7400 -8.9600
9 C8x C 14.0000 -8.2600
10 C8y C 14.0000 -6.8600
11 C8x C 12.7400 -6.1600
12 C8x C 11.5500 -6.8600
13 X F 12.7400 -10.3600
14 C1c C 15.1900 -6.1600
15 C7a C 16.3800 -6.8600
16 C1a C 15.1900 -4.8300
17 O6a O 16.3800 -8.2600
18 O7a O 17.6400 -6.1600
19 C1c C 18.8407 -6.8799
20 O7a O 20.0646 -6.2000
21 C7a C 21.2974 -6.9387
22 C1a C 18.8178 -8.2599
23 C1a C 22.5113 -6.2637
24 O6a O 21.2747 -8.3300
BOND 25
1 4 5 2
2 5 6 1
3 7 8 2
4 8 9 1
5 9 10 2
6 10 11 1
7 11 12 2
8 12 7 1
9 6 1 2
10 8 13 1
11 10 14 1
12 2 7 1
13 14 15 1
14 1 2 1
15 14 16 1
16 2 3 2
17 15 17 2
18 3 4 1
19 15 18 1
20 18 19 1
21 19 20 1
22 20 21 1
23 19 22 1
24 21 23 1
25 21 24 2
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