KEGG   DRUG: GliclazideHelp
Entry
D01599                      Drug                                   

Name
Gliclazide (JP17/INN);
Glimicron (TN)
Formula
C15H21N3O3S
Exact mass
323.1304
Mol weight
323.4105
Structure
Mol fileKCF fileDB search
Class
Antidiabetic agent
 DG01790  Sulfonamide hypoglycemic
  DG01734  Sulfonamide type sulfonylurea receptor agonist
 DG01508  Sulfonylurea receptor agonist
 DG02044  Hypoglycemics
  DG01790  Sulfonamide hypoglycemic
   DG01734  Sulfonamide type sulfonylurea receptor agonist
Remark
Therapeutic category: 3961
ATC code: A10BB09
Product: D01599<JP>
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
Comment
Sulfonylurea
Target
ABCC8 (SUR1) [HSA:6833] [KO:K05032]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Interaction
Drug interaction
Structure map
map07018  Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB09 Gliclazide
      D01599  Gliclazide (JP17/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D01599  Gliclazide (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8 (SUR1)
     D01599  Gliclazide (JP17/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01599  Gliclazide
Drug classes of therapeutic agents [br08360.html]
 Antidiabetic agents
  D01599
BRITE hierarchy
Other DBs
CAS: 21187-98-4
PubChem: 7848662
ChEBI: 31654
ChEMBL: CHEMBL427216
DrugBank: DB01120
PDB-CCD: GCZ[PDBj]
LigandBox: D01599
NIKKAJI: J3.151H
LinkDB All DBs
KCF data Show

ATOM        22
            1   S4a S    16.8000  -16.3800
            2   C8y C    15.6100  -17.0800
            3   N1b N    18.2700  -17.0800
            4   O3c O    17.5700  -15.1900
            5   O3c O    15.8200  -15.1200
            6   C8x C    14.4200  -16.3800
            7   C8x C    15.6100  -18.4100
            8   C5a C    19.4600  -16.3800
            9   C8x C    13.2300  -17.0800
            10  C8x C    14.4200  -19.1100
            11  N1b N    20.6500  -17.0100
            12  C8y C    13.2300  -18.4100
            13  C1a C    12.0400  -19.1100
            14  N1y N    21.7700  -16.3100
            15  C1x C    21.7700  -14.9100
            16  C1x C    23.1000  -16.7300
            17  C1y C    23.9400  -15.6100
            18  C1y C    23.1000  -14.4900
            19  C1x C    23.9400  -13.3000
            20  C1x C    25.2700  -13.7900
            21  C1x C    25.2700  -15.1900
            22  O5a O    19.4600  -14.9800
BOND        24
            1     6   9 2
            2     7  10 1
            3     8  11 1
            4     9  12 1
            5    12  13 1
            6    10  12 2
            7    11  14 1
            8     1   2 1
            9     1   3 1
            10   14  15 1
            11   15  18 1
            12   17  16 1
            13   16  14 1
            14    1   4 2
            15    1   5 2
            16    2   6 1
            17    2   7 2
            18    3   8 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  17 1
            24    8  22 2

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