KEGG   DRUG: Cefditoren pivoxil
Entry
D01628                      Drug                                   
Name
Cefditoren pivoxil (JP18/USAN);
Meiact (TN);
Spectracef (TN)
Formula
C25H28N6O7S3
Exact mass
620.1182
Mol weight
620.73
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01776  Third-generation cephalosporin
 DG01804  Oxyimino beta-lactam
Remark
Therapeutic category: 6132
ATC code: J01DD16
Chemical structure group: DG00584
Product (DG00584): D01628<JP>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
  Disease
Pharyngitis/tonsillitis [DS:H01424]
Comment
Active form of prodrug: Cefditoren [DR:D07639]
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07013  Cephalosporins - oral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DD Third-generation cephalosporins
     J01DD16 Cefditoren
      D01628  Cefditoren pivoxil (JP18/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D01628  Cefditoren pivoxil (JP18/USAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00584  Cefditoren
      D01628  Cefditoren pivoxil
  DG01776  Third-generation cephalosporin
   DG00584  Cefditoren
    D01628  Cefditoren pivoxil
  DG01804  Oxyimino beta-lactam
   DG00584  Cefditoren
    D01628  Cefditoren pivoxil
Drug classes [BR:br08332]
 Antibacterial
  DG01488  Cephem
   D01628  Cefditoren pivoxil
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Third-generation cephalosporin
    D01628  Cefditoren pivoxil (JP18/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01628  Cefditoren pivoxil
  D01628  Cefditoren pivoxil tablets
  D01628  Cefditoren pivoxil fine granules
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01628
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01628
Prodrugs [br08324.html]
 D01628
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00584  Cefditoren
  DG01776  Third-generation cephalosporin
   DG00584  Cefditoren
  DG01804  Oxyimino beta-lactam
   DG00584  Cefditoren
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Third-generation cephalosporin
    DG00584  Cefditoren
Other DBs
CAS: 117467-28-4
PubChem: 7848691
ChEBI: 560555
LigandBox: D01628
NIKKAJI: J419.563I
LinkDB
KCF data

ATOM        41
            1   C1y C    27.8866  -17.6079
            2   N1y N    27.8866  -19.0055
            3   C2y C    29.0746  -19.7043
            4   C2y C    30.2625  -19.0055
            5   C1x C    30.2625  -17.6079
            6   S2x S    29.0746  -16.9091
            7   C1y C    26.4890  -17.6079
            8   C5x C    26.4890  -19.0055
            9   N1b N    25.3010  -16.9091
            10  C5a C    24.0432  -17.6079
            11  O5a O    24.0432  -19.0055
            12  O5x O    25.3010  -19.7043
            13  C2c C    22.8552  -16.9091
            14  C2b C    31.4505  -19.7043
            15  C8y C    21.6673  -17.6079
            16  C2b C    32.7083  -19.0055
            17  C8x C    20.5492  -16.7693
            18  S2x S    19.3612  -17.5380
            19  C8y C    19.7805  -18.9357
            20  N5x N    21.1781  -18.9356
            21  C7a C    29.0746  -21.3814
            22  O7a O    27.8167  -22.0802
            23  O6a O    30.2625  -22.0802
            24  C1b C    26.6288  -21.4513
            25  O7a O    25.5107  -22.0802
            26  C7a C    24.3227  -21.4513
            27  C1d C    23.1348  -22.0802
            28  O6a O    24.3227  -20.0537
            29  C1a C    21.8769  -22.7790
            30  C1a C    22.4360  -20.8922
            31  C1a C    23.8336  -23.3380
            32  N2b N    22.8552  -15.5115
            33  N1a N    18.8721  -20.0537
            34  O2a O    24.0432  -14.8127
            35  C1a C    24.0432  -13.4151
            36  C8y C    32.7083  -17.6079
            37  C8y C    33.8390  -16.7864
            38  N5x N    33.4071  -15.4572
            39  C8x C    32.0095  -15.4572
            40  S2x S    31.5777  -16.7864
            41  C1a C    35.1480  -17.2121
BOND        44
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16   13  15 1
            17   14  16 2
            18   15  17 2
            19   17  18 1
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23    3  21 1
            24   21  22 1
            25   21  23 2
            26   22  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   26  28 2
            31   27  29 1
            32   27  30 1
            33   27  31 1
            34   13  32 2
            35   19  33 1
            36   32  34 1
            37   34  35 1
            38   16  36 1
            39   36  37 2
            40   37  38 1
            41   38  39 2
            42   39  40 1
            43   36  40 1
            44   37  41 1

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