KEGG   DRUG: FelbinacHelp
Entry
D01675                      Drug                                   

Name
Felbinac (JP17/USAN/INN);
Dolinac (TN);
Felbinac (TN)
Formula
C14H12O2
Exact mass
212.0837
Mol weight
212.2439
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01906  Antiinflammatory drug, acetic acid derivatives
  DG01898  Antiinflammatory drug, phenylacetic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01906  Antiinflammatory drug, acetic acid derivatives
   DG01898  Antiinflammatory drug, phenylacetic acid derivatives
Remark
Therapeutic category: 2649
ATC code: M02AA08
Chemical structure group: DG00764
Product (DG00764): D01675<JP>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Comment
Phenylacetic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA08 Felbinac
      D01675  Felbinac (JP17/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D01675  Felbinac (JP17/USAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01675  Felbinac (JP17/USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Felbinac
    D01675  Felbinac (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01675  Felbinac (JP17/USAN/INN) <JP>
    PTGS2 (COX2)
     D01675  Felbinac (JP17/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01675 Felbinac
  D01675  Felbinac tape
  D01675  Felbinac cataplasm
Rx-to-OTC switch list in Japan [br08314.html]
 D01675
BRITE hierarchy
Other DBs
CAS: 5728-52-9
PubChem: 7848738
ChEBI: 31597
ChEMBL: CHEMBL413965
PDB-CCD: BP4[PDBj]
LigandBox: D01675
NIKKAJI: J105.145H
LinkDB All DBs
KCF data Show

ATOM        16
            1   C8x C    18.2700  -14.2800
            2   C8x C    18.2700  -15.6800
            3   C8x C    19.4824  -16.3800
            4   C8x C    20.6949  -15.6800
            5   C8y C    20.6949  -14.2800
            6   C8x C    19.4824  -13.5800
            7   C8y C    21.9260  -13.5690
            8   C8x C    23.1312  -14.2647
            9   C8x C    24.3435  -13.5646
            10  C8y C    24.3435  -12.1646
            11  C8x C    23.1383  -11.4689
            12  C8x C    21.9259  -12.1690
            13  C1b C    25.5614  -11.4612
            14  C6a C    26.7734  -12.1607
            15  O6a O    27.9523  -11.4798
            16  O6a O    26.7740  -13.5796
BOND        17
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   14  16 2

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