KEGG   DRUG: Epinastine hydrochlorideHelp
Entry
D01713                      Drug                                   

Name
Epinastine hydrochloride (JAN);
Alesion (TN);
Elestat (TN)
Product
  Generic
Formula
C16H15N3. HCl
Exact mass
285.1033
Mol weight
285.7713
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
Therapeutic category: 1319 4490
ATC code: R06AX24 S01GX10
Chemical structure group: DG01116
Product (DG01116): D01713<JP/US>
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Drug interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX24 Epinastine
      D01713  Epinastine hydrochloride (JAN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX10 Epinastine
      D01713  Epinastine hydrochloride (JAN) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Epinastine
    D01713  Epinastine hydrochloride (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01713  Epinastine hydrochloride (JAN)
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01713  Epinastine hydrochloride (JAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D01713  Epinastine hydrochloride (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Epinastine
    D01713  Epinastine hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01713  Epinastine hydrochloride (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01713
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01713
Rx-to-OTC switch list in Japan [br08314.html]
 D01713
BRITE hierarchy
Other DBs
CAS: 108929-04-0
PubChem: 7848776
ChEMBL: CHEMBL1200491
DrugBank: DB00751
LigandBox: D01713
NIKKAJI: J439.015F
LinkDB All DBs
KCF data Show

ATOM        20
            1   C1y C    41.4777  -20.8394
            2   C8y C    40.6389  -21.9579
            3   C8y C    40.9884  -23.2861
            4   C1x C    42.2467  -23.8453
            5   N1y N    42.8758  -20.8394
            6   C8y C    43.4351  -23.2861
            7   C8y C    43.7846  -21.8880
            8   C8x C    39.9398  -24.2647
            9   C8x C    38.6116  -23.8453
            10  C8x C    38.2621  -22.5171
            11  C8x C    39.3107  -21.5385
            12  C8x C    45.1128  -21.4685
            13  C8x C    46.1614  -22.3773
            14  C8x C    45.8118  -23.7754
            15  C8x C    44.4836  -24.1948
            16  C1x C    40.9884  -19.5112
            17  N2x N    42.1069  -18.6723
            18  C2y C    43.2953  -19.4413
            19  N1a N    44.6235  -19.0219
            20  X   Cl   48.3983  -22.4472
BOND        22
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    1  16 1
            19   16  17 1
            20   17  18 2
            21    5  18 1
            22   18  19 1

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