| Entry |
|
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| Name |
Idarubicin hydrochloride (JP18/USP);
Idamycin (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C26H27NO9. HCl
|
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| Exact mass |
533.1453
|
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| Mol weight |
533.95
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Antineoplastic
DG01682 Anthracycline antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
|
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| Remark |
| Therapeutic category: | 4235 |
| Product (DG00700): | D01747<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Topoisomerase II inhibitor |
|---|
| Disease |
Acute myeloid leukemia [DS: H00003] |
|---|
| Target |
|
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| Interaction |
|
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| Structure map |
| map07042 | Antineoplastics - agents from natural products |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
L01DB Anthracyclines and related substances
L01DB06 Idarubicin
D01747 Idarubicin hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Molecular Target Inhibitors
Topoisomerase Inhibitors
Idarubicin
D01747 Idarubicin hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
423 Antibiotics
4235 Anthracycline antibiotics
D01747 Idarubicin hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Antineoplastic
DG01682 Anthracycline antineoplastic
DG00700 Idarubicin
D01747 Idarubicin hydrochloride
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG00700 Idarubicin
D01747 Idarubicin hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
Isomerases (EC5)
DNA topoisomerase
TOP2
D01747 Idarubicin hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01747 Idarubicin hydrochloride
D01747 Idarubicin hydrochloride for injection
Drug groups [BR:br08330]
Antineoplastic
DG01682 Anthracycline antineoplastic
DG00700 Idarubicin
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG00700 Idarubicin
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 37
1 X Cl 38.2200 -13.1600
2 C8x C 22.4700 -11.7600
3 C8x C 22.4700 -13.1600
4 C8x C 23.6600 -13.8600
5 C8y C 24.9200 -13.1600
6 C8y C 24.9200 -11.7600
7 C8x C 23.6600 -11.0600
8 C5x C 26.1100 -13.8600
9 C8y C 27.3000 -13.1600
10 C8y C 27.3000 -11.7600
11 C5x C 26.1100 -11.0600
12 C8y C 28.5600 -13.8600
13 C8y C 29.7500 -13.1600
14 C8y C 29.7500 -11.7600
15 C8y C 28.5600 -11.0600
16 C1y C 30.9400 -13.8600
17 C1x C 32.2000 -13.1600
18 C1z C 32.2000 -11.7600
19 C1x C 30.9400 -11.0600
20 O5x O 26.1100 -9.6600
21 O5x O 26.1100 -15.2600
22 O1a O 28.5600 -9.6600
23 O1a O 28.5600 -15.2600
24 C5a C 33.3900 -10.8500
25 C1a C 34.5800 -11.5500
26 O5a O 33.3900 -9.4500
27 O1a O 33.3900 -12.6000
28 O2a O 30.9400 -15.2600
29 C1y C 32.1300 -15.9600
30 C1x C 32.1300 -17.3600
31 C1y C 33.3900 -18.0600
32 C1y C 34.5800 -17.3600
33 C1y C 34.5800 -15.9600
34 O2x O 33.3900 -15.2600
35 C1a C 35.7700 -15.2600
36 O1a O 35.7700 -18.0600
37 N1a N 33.3900 -19.4600
BOND 40
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 5 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 6 11 1
12 9 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 10 15 2
17 13 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 14 19 1
22 11 20 2
23 8 21 2
24 15 22 1
25 12 23 1
26 18 24 1 #Up
27 24 25 1
28 24 26 2
29 18 27 1 #Down
30 16 28 1 #Down
31 29 28 1 #Down
32 29 30 1
33 30 31 1
34 31 32 1
35 32 33 1
36 33 34 1
37 29 34 1
38 33 35 1 #Up
39 32 36 1 #Up
40 31 37 1 #Up
|
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