KEGG   DRUG: Sapropterin dihydrochlorideHelp
Entry
D01798                      Drug                                   

Name
Sapropterin dihydrochloride (USAN);
Sapropterin hydrochloride (JAN);
Biopten (TN);
Kuvan (TN)
Product
Formula
C9H15N5O3. 2HCl
Exact mass
313.0708
Mol weight
314.169
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Therapeutic category: 3999
ATC code: A16AX07
Chemical structure group: DG00147
Product (DG00147): D01798<JP/US>
Efficacy
Antihyperphenylalaninemia, Cofactor replacement (tetrahydrobiopterin)
  Disease
Phenylketonuria, BH4-responsive [DS:H00167]
Comment
Cofactor replacement
Treatment of mild-to-moderate phenylketonuria (PKU)
Target
  Network
N10019  Replacement of cofactor BH4 for deficient QDPR
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AX Various alimentary tract and metabolism products
     A16AX07 Sapropterin
      D01798  Sapropterin dihydrochloride (USAN) <JP/US>
USP drug classification [BR:br08302]
 Genetic or Enzyme Disorder: Replacement, Modifiers, Treatment
  Sapropterin
   D01798  Sapropterin dihydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D01798  Sapropterin dihydrochloride (USAN); Sapropterin hydrochloride (JAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01798
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01798
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01798
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D01798
BRITE hierarchy
Other DBs
CAS: 69056-38-8
PubChem: 7848860
ChEBI: 32120
ChEMBL: CHEMBL1201775
LigandBox: D01798
NIKKAJI: J1.219.960K
LinkDB All DBs
KCF data Show

ATOM        19
            1   N5x N    19.7015  -17.4044
            2   C8y C    19.7015  -18.8056
            3   N4x N    20.9179  -19.5062
            4   C8y C    20.9179  -16.7038
            5   C8y C    22.1272  -17.4044
            6   C8y C    22.1211  -18.8056
            7   N1x N    23.3315  -19.5114
            8   C1x C    24.5481  -18.8159
            9   C1y C    24.5541  -17.4147
            10  N1x N    23.3436  -16.7090
            11  C1c C    25.7591  -16.7180
            12  C1c C    26.9692  -17.4186
            13  C1a C    28.1793  -16.7250
            14  O1a O    26.9661  -18.8198
            15  O1a O    25.7596  -15.3169
            16  N1a N    18.4884  -19.5068
            17  O5x O    20.9196  -15.3026
            18  X   Cl   31.9459  -17.9706
            19  X   Cl   31.9459  -17.9706
BOND        18
            1     8   9 1
            2     9  10 1
            3    10   5 1
            4     4   1 1
            5     9  11 1
            6    11  12 1
            7    12  13 1
            8     1   2 2
            9    12  14 1 #Down
            10    2   3 1
            11   11  15 1 #Up
            12    3   6 1
            13    2  16 1
            14    5   4 1
            15    4  17 2
            16    5   6 2
            17    6   7 1
            18    7   8 1
BRACKET     1    30.8700  -18.9700   30.8700  -17.0800
            1    32.5500  -17.0800   32.5500  -18.9700
            1  2
 ORIGINAL  1   19
 REPEAT    1   20

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