KEGG   DRUG: Alclometasone dipropionateHelp
Entry
D01820                      Drug                                   

Name
Alclometasone dipropionate (JAN/USP);
Aclovate (TN)
Product
  Generic
Formula
C28H37ClO7
Exact mass
520.2228
Mol weight
521.0422
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: D07AB10 S01BA10
Chemical structure group: DG00415
Product (DG00415): D01820<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB10 Alclometasone
      D01820  Alclometasone dipropionate (JAN/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA10 Alclometasone
      D01820  Alclometasone dipropionate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Alclometasone
   D01820  Alclometasone dipropionate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01820  Alclometasone dipropionate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01820  Alclometasone dipropionate (JAN/USP) <JP/US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D01820
 Classification in Japan
  D01820
BRITE hierarchy
Other DBs
CAS: 66734-13-2
PubChem: 7848882
ChEBI: 31184
ChEMBL: CHEMBL1200989 CHEMBL1377952
DrugBank: DB00240
LigandBox: D01820
NIKKAJI: J18.599J
LinkDB All DBs
KCF data Show

ATOM        36
            1   C2x C    19.1662  -17.6173
            2   C5x C    19.1662  -18.9788
            3   C2x C    20.3484  -19.6596
            4   C2x C    20.3484  -16.9363
            5   C1z C    21.5234  -17.6173
            6   C2y C    21.5174  -18.9788
            7   C1x C    22.6938  -19.6648
            8   C1y C    23.8760  -18.9889
            9   C1y C    22.7055  -16.9416
            10  C1y C    23.8760  -17.6302
            11  C1x C    23.8982  -14.9141
            12  C1y C    22.6466  -15.5835
            13  C1z C    25.0689  -15.6027
            14  C1y C    25.0525  -16.9568
            15  C1x C    27.4434  -16.9390
            16  C1y C    27.4139  -15.6313
            17  C1z C    26.2495  -14.9400
            18  O5x O    17.9874  -19.6603
            19  C1a C    21.5112  -16.2556
            20  X   Cl   25.0537  -19.6724
            21  C1a C    25.0598  -14.2869
            22  O1a O    21.5430  -14.8930
            23  C5a C    26.2425  -13.2278
            24  C1b C    25.0599  -12.5530
            25  O7a O    27.4252  -14.2477
            26  O5a O    27.4136  -12.5401
            27  C7a C    29.1328  -14.2477
            28  C1a C    28.7732  -15.6300
            29  O7a O    23.8841  -13.2399
            30  C7a C    22.7016  -12.5652
            31  C1b C    21.5257  -13.2520
            32  O6a O    22.6705  -11.1576
            33  C1a C    20.3430  -12.5773
            34  O6a O    29.8136  -15.4267
            35  C1b C    29.8136  -13.0685
            36  C1a C    31.1753  -13.0685
BOND        39
            1     2  18 2
            2     9   5 1
            3     5  19 1 #Up
            4     5   4 1
            5     4   1 2
            6     8  20 1 #Down
            7     1   2 1
            8     9  10 1
            9    13  21 1 #Up
            10   10  14 1
            11   12  22 1 #Up
            12   13  11 1
            13   17  23 1 #Up
            14   23  26 2
            15   11  12 1
            16   23  24 1
            17   12   9 1
            18   17  25 1 #Down
            19    2   3 1
            20    3   6 2
            21   25  27 1
            22    5   6 1
            23   16  28 1 #Down
            24    6   7 1
            25   24  29 1
            26    7   8 1
            27   29  30 1
            28   13  14 1
            29   30  31 1
            30   15  16 1
            31   30  32 2
            32   16  17 1
            33   31  33 1
            34   17  13 1
            35   27  34 2
            36   14  15 1
            37   27  35 1
            38    8  10 1
            39   35  36 1

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