KEGG   DRUG: Fluocinolone acetonideHelp
Entry
D01825                      Drug                                   

Name
Fluocinolone acetonide (JP17/USP/INN);
Fluocet (TN);
Retisert (TN);
Synalar (TN)
Product
  Generic
FLUOCINOLONE ACETONIDE (Amneal Pharmaceuticals), FLUOCINOLONE ACETONIDE (Amneal Pharmaceuticals), FLUOCINOLONE ACETONIDE (Amneal Pharmaceuticals), FLUOCINOLONE ACETONIDE (AvKARE), FLUOCINOLONE ACETONIDE (AvKARE), FLUOCINOLONE ACETONIDE (AvKARE), FLUOCINOLONE ACETONIDE (E. FOUGERA &), FLUOCINOLONE ACETONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINOLONE ACETONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINOLONE ACETONIDE (G&W Laboratories), FLUOCINOLONE ACETONIDE (G&W Laboratories), FLUOCINOLONE ACETONIDE (G&W Laboratories), FLUOCINOLONE ACETONIDE (Glasshouse Pharmaceuticals Limited Canada), FLUOCINOLONE ACETONIDE (Lupin Pharmaceuticals), FLAC OTIC OIL (Patrin Pharma), FLUOCINOLONE ACETONIDE (Perrigo New York), FLUOCINOLONE ACETONIDE (Perrigo New York), FLUOCINOLONE ACETONIDE (Perrigo New York), FLUOCINOLONE ACETONIDE (Rising Pharmaceuticals), FLUOCINOLONE ACETONIDE (Rising Pharmaceuticals), XILAPAK (SOLUTECH PHARMACEUTICALS LLC), FLUOCINOLONE ACETONIDE (Seton Pharmaceuticals), FLUOCINOLONE ACETONIDE (Seton Pharmaceuticals), FLUOCINOLONE ACETONIDE 0.01% (Seton Pharmaceuticals), FLUOCINOLONE ACETONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINOLONE ACETONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINOLONE ACETONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINOLONE ACETONIDE (Teligent Pharma), FLUOCINOLONE ACETONIDE (Teligent Pharma), FLUOCINOLONE ACETONIDE (Teligent Pharma), FLUOCINOLONE ACETONIDE (VersaPharm Inc. - an Akorn Company), FLUOCINOLONE ACETONIDE (Lyne Laboratories), FLUOCINOLONE ACETONIDE (Lyne Laboratories), FLUOCINOLONE ACETONIDE (Lyne Laboratories), FLUOCINOLONE ACETONIDE (Rising Pharmaceuticals), FLUOCINOLONE ACETONIDE TOPICAL (Actavis Pharma)
Formula
C24H30F2O6
Exact mass
452.201
Mol weight
452.4882
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: C05AA10 D07AC04 S01BA15 S02BA08
Product: D01825<JP/US>
Product (mixture): D04795<JP/US> D11089<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA10 Fluocinolone acetonide
      D01825  Fluocinolone acetonide (JP17/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC04 Fluocinolone acetonide
      D01825  Fluocinolone acetonide (JP17/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA15 Fluocinolone acetonide
      D01825  Fluocinolone acetonide (JP17/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA08 Fluocinolone acetonide
      D01825  Fluocinolone acetonide (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Fluocinolone
   D01825  Fluocinolone acetonide (JP17/USP/INN)
  Fluocinolone
   D01825  Fluocinolone acetonide (JP17/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Fluocinolone
    D01825  Fluocinolone acetonide (JP17/USP/INN)
 Otic Agents
  Fluocinolone
   D01825  Fluocinolone acetonide (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01825  Fluocinolone acetonide (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D01825  Fluocinolone acetonide (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Fluocinolone acetonide
    D01825  Fluocinolone acetonide (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Fluocinolone acetonide
    D01825  Fluocinolone acetonide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01825  Fluocinolone acetonide (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01825  Fluocinolone acetonide
Topical steroids potency [br08317.html]
 Classification in the USA
  D01825
 Classification in Japan
  D01825
BRITE hierarchy
Other DBs
CAS: 67-73-2
PubChem: 7848887
ChEBI: 31623
ChEMBL: CHEMBL279775 CHEMBL989
DrugBank: DB00591
LigandBox: D01825
NIKKAJI: J1.414A
LinkDB All DBs
KCF data Show

ATOM        32
            1   C2x C    18.6900  -29.1900
            2   C5x C    18.6900  -30.5200
            3   C2x C    19.8800  -31.2200
            4   C2y C    21.0700  -30.5200
            5   C1z C    21.0700  -29.1900
            6   C2x C    19.8800  -28.4900
            7   C1y C    22.2600  -31.2200
            8   C1x C    23.4500  -30.5200
            9   C1y C    23.4500  -29.1900
            10  C1z C    22.2600  -28.4900
            11  C1y C    24.5000  -28.4900
            12  C1z C    24.5000  -27.1600
            13  C1x C    23.4500  -26.4600
            14  C1y C    22.2600  -27.1600
            15  C1x C    26.8800  -28.4900
            16  C1y C    26.8800  -27.1600
            17  C1z C    25.6900  -26.4600
            18  O5x O    17.5700  -31.2200
            19  C1a C    21.0700  -27.7900
            20  X   F    22.2600  -29.8200
            21  O1a O    21.0700  -26.4600
            22  C1a C    24.5000  -25.7600
            23  C5a C    25.6900  -24.8500
            24  O2x O    27.0900  -25.5500
            25  O5a O    26.8800  -24.2200
            26  C1b C    24.5000  -24.2200
            27  O1a O    23.4500  -24.8500
            28  O2x O    28.2800  -27.1600
            29  C1z C    28.4900  -25.5500
            30  C1a C    29.8900  -25.5500
            31  C1a C    28.4900  -24.2200
            32  X   F    22.2600  -32.6200
BOND        36
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Up
            27   17  24 1 #Down
            28   23  25 2
            29   23  26 1
            30   26  27 1
            31   16  28 1 #Down
            32   24  29 1
            33   29  28 1
            34   29  30 1
            35   29  31 1
            36    7  32 1 #Down

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