KEGG   DRUG: Lornoxicam
Entry
D01866                      Drug                                   
Name
Lornoxicam (JP18/USAN/INN);
Lorcam (TN)
Formula
C13H10ClN3O4S2
Exact mass
370.9801
Mol weight
371.82
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01910  Anti-inflammatory drug, oxicams
  DG01922  Selective COX2 inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 1149
ATC code: M01AC05
Product: D01866<JP>
Efficacy
Analgesic, Anti-inflammatory, COX-2 inhibitor
Comment
Oxicams
Target
PTGS2 (COX2) [HSA:5743] [KO:K11987]
PTGS1 (COX1) [HSA:5742] [KO:K00509]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AC Oxicams
     M01AC05 Lornoxicam
      D01866  Lornoxicam (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01866  Lornoxicam (JP18/USAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01910  Anti-inflammatory drug, oxicams
    D01866  Lornoxicam
   DG01922  Selective COX2 inhibitor
    D01866  Lornoxicam
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D01866  Lornoxicam
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D01866  Lornoxicam
   D01866  Lornoxicam
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01866  Lornoxicam (JP18/USAN/INN) <JP>
    PTGS2 (COX2)
     D01866  Lornoxicam (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01866  Lornoxicam
  D01866  Lornoxicam tablets
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01866
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01866
Other DBs
CAS: 70374-39-9
PubChem: 7848928
ChEBI: 31783
LigandBox: D01866
NIKKAJI: J248.069G
LinkDB
KCF data

ATOM        23
            1   C8y C    19.9545  -16.6724
            2   C8y C    21.1625  -17.3723
            3   N4y N    21.1625  -18.7720
            4   S2x S    19.9545  -19.4719
            5   C8y C    18.7394  -17.3723
            6   C8y C    18.7434  -18.7749
            7   C8x C    17.4107  -19.2123
            8   C8y C    16.5831  -18.0799
            9   S2x S    17.4041  -16.9428
            10  O3c O    21.1571  -20.1789
            11  O3c O    18.7322  -20.1717
            12  X   Cl   15.1834  -18.0842
            13  C5a C    22.3751  -16.6734
            14  O5a O    22.3763  -15.2737
            15  N1b N    23.5869  -17.3741
            16  C8y C    24.7996  -16.6751
            17  C8x C    24.7986  -15.2803
            18  C8x C    26.0114  -14.5813
            19  C8x C    27.2229  -15.2820
            20  C8x C    27.2219  -16.6817
            21  N5x N    26.0093  -17.3808
            22  C1a C    22.3751  -19.4710
            23  O1a O    19.9562  -15.2727
BOND        25
            1     4  11 2
            2     5   1 1
            3     8  12 1
            4     1   2 2
            5     2  13 1
            6     2   3 1
            7    13  14 2
            8     3   4 1
            9    13  15 1
            10    5   6 2
            11   15  16 1
            12    6   7 1
            13    7   8 2
            14    8   9 1
            15    9   5 1
            16    4   6 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  16 1
            23    4  10 2
            24    3  22 1
            25    1  23 1

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