| Entry |
|
|---|
| Name |
Lornoxicam (JAN/USAN/INN);
Lorcam (TN) |
|---|
| Formula |
C13H10ClN3O4S2
|
|---|
| Exact mass |
370.9801
|
|---|
| Mol weight |
371.8192
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
DG01922 Selective COX2 inhibitor
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
| Therapeutic category: | 1149 |
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, COX-2 inhibitor |
|---|
| Comment |
Oxicams
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AC Oxicams
M01AC05 Lornoxicam
D01866 Lornoxicam (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D01866 Lornoxicam (JAN/USAN/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
D01866 Lornoxicam
DG01922 Selective COX2 inhibitor
D01866 Lornoxicam
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
D01866 Lornoxicam
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D01866 Lornoxicam
D01866 Lornoxicam
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D01866 Lornoxicam (JAN/USAN/INN) <JP>
PTGS2 (COX2)
D01866 Lornoxicam (JAN/USAN/INN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01866
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01866
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 23
1 C8y C 19.9545 -16.6724
2 C8y C 21.1625 -17.3723
3 N4y N 21.1625 -18.7720
4 S2x S 19.9545 -19.4719
5 C8y C 18.7394 -17.3723
6 C8y C 18.7434 -18.7749
7 C8x C 17.4107 -19.2123
8 C8y C 16.5831 -18.0799
9 S2x S 17.4041 -16.9428
10 O3c O 21.1571 -20.1789
11 O3c O 18.7322 -20.1717
12 X Cl 15.1834 -18.0842
13 C5a C 22.3751 -16.6734
14 O5a O 22.3763 -15.2737
15 N1b N 23.5869 -17.3741
16 C8y C 24.7996 -16.6751
17 C8x C 24.7986 -15.2803
18 C8x C 26.0114 -14.5813
19 C8x C 27.2229 -15.2820
20 C8x C 27.2219 -16.6817
21 N5x N 26.0093 -17.3808
22 C1a C 22.3751 -19.4710
23 O1a O 19.9562 -15.2727
BOND 25
1 4 11 2
2 5 1 1
3 8 12 1
4 1 2 2
5 2 13 1
6 2 3 1
7 13 14 2
8 3 4 1
9 13 15 1
10 5 6 2
11 15 16 1
12 6 7 1
13 7 8 2
14 8 9 1
15 9 5 1
16 4 6 1
17 16 17 2
18 17 18 1
19 18 19 2
20 19 20 1
21 20 21 2
22 21 16 1
23 4 10 2
24 3 22 1
25 1 23 1
|
|---|
