KEGG   DRUG: Travoprost
Entry
D01964                      Drug                                   
Name
Travoprost (JAN/USP/INN);
Travatan (TN)
Product
IDOSE TR (Glaukos Corporation), TRAVATAN Z (Novartis Pharmaceuticals Corporation), TRAVATAN Z (Sandoz)
  Generic
TRAVOPROST (Apotex Corp.), TRAVOPROST (Golden State Medical Supply), TRAVOPROST (Somerset Therapeutics), TRAVOPROST OPHTHALMIC (Micro Labs Limited), TRAVOPROST OPHTHALMIC SOLUTION (Bryant Ranch Prepack), TRAVOPROST OPHTHALMIC SOLUTION (Bryant Ranch Prepack), TRAVOPROST OPHTHALMIC SOLUTION (Gland Pharma Limited), TRAVOPROST OPHTHALMIC SOLUTION (Sandoz), TRAVOPROST OPHTHALMIC SOLUTION USP, 0.004% (Alembic Pharmaceuticals), TRAVOPROST OPHTHALMIC SOLUTION, 0.004% (Mylan Pharmaceuticals)
Formula
C26H35F3O6
Exact mass
500.2386
Mol weight
500.55
Structure
Simcomp
Class
Hormonal agent
 DG01961  Prostaglandin derivative
  DG01960  Prostaglandin F derivative
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Therapeutic category: 1319
ATC code: S01EE04
Product: D01964<JP/US>
Product (mixture): D09815<JP>
Efficacy
Antiglaucoma, Prostaglandin F receptor agonist
  Disease
Open-angle glaucoma [DS:H00612]
Comment
Prostaglandin derivative
Target
PTGFR [HSA:5737] [KO:K04262]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07035  Prostaglandins
map07054  Antiglaucoma agents
map07228  Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EE Prostaglandin analogues
     S01EE04 Travoprost
      D01964  Travoprost (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Prostaglandin and Prostamide Analogs, Ophthalmic
    Travoprost
     D01964  Travoprost (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01964  Travoprost (JAN/USP/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01961  Prostaglandin derivative
   DG01960  Prostaglandin F derivative
    D01964  Travoprost
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D01964  Travoprost
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D01964  Travoprost
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    PTGFR
     D01964  Travoprost (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01964
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01964
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01964
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01964
Other DBs
CAS: 157283-68-6
PubChem: 7849026
ChEBI: 746859
LigandBox: D01964
NIKKAJI: J1.152.432J
LinkDB
KCF data

ATOM        35
            1   C1y C    19.2500  -20.4400
            2   C1y C    19.2500  -21.8400
            3   C1y C    17.8500  -20.0200
            4   C1b C    20.4400  -19.7400
            5   C1y C    17.9200  -22.2600
            6   C2b C    20.4400  -22.5400
            7   C1x C    17.0800  -21.1400
            8   C2b C    21.6300  -20.4400
            9   O1a O    17.5000  -23.6600
            10  C2b C    21.6300  -21.8400
            11  C1c C    22.8900  -22.5400
            12  C1b C    24.0800  -21.8400
            13  O1a O    22.8900  -23.9400
            14  O2a O    25.3400  -22.5400
            15  C8y C    25.3400  -23.9400
            16  C8x C    26.5300  -24.6400
            17  C8y C    26.5300  -26.0400
            18  C8x C    25.3400  -26.7400
            19  C8x C    24.0800  -26.0400
            20  C8x C    24.0800  -24.6400
            21  O1a O    17.3600  -18.6900
            22  C2b C    23.0300  -20.4400
            23  C1b C    24.2200  -19.7400
            24  C1b C    25.4100  -20.4400
            25  C1b C    26.6000  -19.7400
            26  C7a C    27.7900  -20.4400
            27  O7a O    28.9800  -19.7400
            28  C1c C    30.1700  -20.4400
            29  C1a C    31.3600  -19.7400
            30  O6a O    27.7900  -21.8400
            31  C1a C    30.1700  -21.8400
            32  C1d C    27.7453  -26.7351
            33  X   F    28.9337  -26.0423
            34  X   F    27.7511  -28.1397
            35  X   F    28.9435  -27.4205
BOND        36
            1    12  14 1
            2     5   7 1
            3    14  15 1
            4     1   2 1
            5     1   3 1
            6     1   4 1 #Down
            7     2   5 1
            8     2   6 1 #Up
            9    15  16 2
            10   16  17 1
            11   17  18 2
            12   18  19 1
            13   19  20 2
            14   20  15 1
            15    3   7 1
            16    4   8 1
            17    5   9 1 #Down
            18    6  10 2
            19   10  11 1
            20   11  12 1
            21   11  13 1 #Down
            22    3  21 1 #Down
            23    8  22 2
            24   23  24 1
            25   23  22 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   26  30 2
            32   28  31 1
            33   17  32 1
            34   32  33 1
            35   32  34 1
            36   32  35 1

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