KEGG   DRUG: Sultopride hydrochloride
Entry
D02208                      Drug                                   
Name
Sultopride hydrochloride (JAN);
Sultopride monohydrochloride;
Barnetil (TN)
Formula
C17H26N2O4S. HCl
Exact mass
390.138
Mol weight
390.9253
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01941  Benzamide antipsychotic
Remark
Therapeutic category: 1179
ATC code: N05AL02
Chemical structure group: DG00900
Product (DG00900): D02208<JP>
Efficacy
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist
Comment
Benzamide derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AL Benzamides
     N05AL02 Sultopride
      D02208  Sultopride hydrochloride (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D02208  Sultopride hydrochloride (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00900  Sultopride
     D02208  Sultopride hydrochloride
  DG03200  Antipsychotic agent
   DG01941  Benzamide antipsychotic
    DG00900  Sultopride
     D02208  Sultopride hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02208  Sultopride hydrochloride (JAN) <JP>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00900  Sultopride
  DG03200  Antipsychotic agent
   DG01941  Benzamide antipsychotic
    DG00900  Sultopride
Other DBs
CAS: 23694-17-9
PubChem: 7849268
LigandBox: D02208
NIKKAJI: J352.952E
LinkDB
KCF data

ATOM        25
            1   X   Cl   26.4506  -16.1781
            2   S4a S    13.7200  -17.2200
            3   C1b C    12.5300  -17.9200
            4   O3c O    14.4200  -18.4800
            5   O3c O    13.0200  -16.0300
            6   C8y C    14.9100  -16.5200
            7   C8x C    14.9100  -15.1200
            8   C8x C    16.1700  -14.4200
            9   C8x C    16.1700  -17.2200
            10  C8y C    17.3600  -16.5200
            11  C8y C    17.3600  -15.1200
            12  O2a O    18.5500  -14.4200
            13  C5a C    18.5500  -17.2200
            14  N1b N    19.8100  -16.5200
            15  C1b C    21.0000  -17.2200
            16  O5a O    18.5500  -18.6200
            17  C1a C    18.5500  -13.0200
            18  C1a C    11.2700  -17.2200
            19  C1y C    22.2600  -16.5900
            20  N1y N    23.3800  -17.3600
            21  C1x C    24.5000  -16.5200
            22  C1x C    24.0100  -15.2600
            23  C1x C    22.6800  -15.2600
            24  C1b C    23.3800  -18.6900
            25  C1a C    24.6400  -19.3900
BOND        25
            1    14  13 1
            2    13  10 1
            3     2   5 2
            4     6   7 2
            5     7   8 1
            6    15  14 1
            7     8  11 2
            8    10   9 2
            9     9   6 1
            10    2   6 1
            11    2   3 1
            12   13  16 2
            13    2   4 2
            14   10  11 1
            15   11  12 1
            16   12  17 1
            17    3  18 1
            18   15  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   19  23 1
            24   20  24 1
            25   24  25 1

» Japanese version   » Back

KEGG   DRUG: Sultopride
Entry
D08549                      Drug                                   
Name
Sultopride (INN)
Formula
C17H26N2O4S
Exact mass
354.1613
Mol weight
354.4643
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01941  Benzamide antipsychotic
Remark
Same as: C11708
ATC code: N05AL02
Chemical structure group: DG00900
Product (DG00900): D02208<JP>
Efficacy
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist
Comment
Benzamide derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AL Benzamides
     N05AL02 Sultopride
      D08549  Sultopride (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00900  Sultopride
     D08549  Sultopride
  DG03200  Antipsychotic agent
   DG01941  Benzamide antipsychotic
    DG00900  Sultopride
     D08549  Sultopride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D08549  Sultopride (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00900  Sultopride
  DG03200  Antipsychotic agent
   DG01941  Benzamide antipsychotic
    DG00900  Sultopride
Other DBs
CAS: 53583-79-2
PubChem: 96025234
ChEBI: 9356
LigandBox: D08549
NIKKAJI: J10.063C
LinkDB
KCF data

ATOM        24
            1   S4a S    11.7600  -21.2800
            2   C1b C    10.5700  -21.9800
            3   O3c O    12.4600  -22.5400
            4   O3c O    11.0600  -20.0900
            5   C8y C    12.9500  -20.5800
            6   C8x C    12.9500  -19.1800
            7   C8x C    14.2100  -18.4800
            8   C8x C    14.2100  -21.2800
            9   C8y C    15.4000  -20.5800
            10  C8y C    15.4000  -19.1800
            11  O2a O    16.5900  -18.4800
            12  C5a C    16.5900  -21.2800
            13  N1b N    17.8500  -20.5800
            14  C1b C    19.0400  -21.2800
            15  O5a O    16.5900  -22.6800
            16  C1a C    16.5900  -17.0800
            17  C1a C     9.3100  -21.2800
            18  C1y C    20.2581  -20.5899
            19  N1y N    21.3786  -21.3805
            20  C1x C    22.4727  -20.5554
            21  C1x C    22.0262  -19.2598
            22  C1x C    20.6560  -19.2842
            23  C1b C    21.3297  -22.7491
            24  C1a C    22.6385  -23.4393
BOND        25
            1    13  12 1
            2    12   9 1
            3     1   4 2
            4     5   6 2
            5     6   7 1
            6    14  13 1
            7     7  10 2
            8     9   8 2
            9     8   5 1
            10    1   5 1
            11    1   2 1
            12   12  15 2
            13    1   3 2
            14    9  10 1
            15   10  11 1
            16   11  16 1
            17    2  17 1
            18   14  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   18  22 1
            24   19  23 1
            25   23  24 1

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