| Entry |
|
|---|
| Name |
Clocapramine hydrochloride hydrate (JP18);
Clofekton (TN) |
|---|
| Formula |
C28H37ClN4O. 2HCl. H2O
|
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| Exact mass |
570.2295
|
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| Mol weight |
572.00
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01942 Iminobenzyl antipsychotic
|
|---|
| Remark |
| Therapeutic category: | 1179 |
| Product (DG01313): | D02371<JP> |
|
|---|
| Efficacy |
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Iminodibenzyl derivative
|
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| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07213 | Dopamine receptor agonists/antagonists |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D02371 Clocapramine hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG01313 Clocapramine
D02371 Clocapramine hydrochloride hydrate
DG03200 Antipsychotic agent
DG01942 Iminobenzyl antipsychotic
DG01313 Clocapramine
D02371 Clocapramine hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D02371 Clocapramine hydrochloride hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02371 Clocapramine hydrochloride hydrate
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG01313 Clocapramine
DG03200 Antipsychotic agent
DG01942 Iminobenzyl antipsychotic
DG01313 Clocapramine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 37
1 C1x C 15.4700 -20.7200
2 C8y C 14.6300 -19.6000
3 C8y C 14.9800 -18.2700
4 N1y N 16.2400 -17.7100
5 C1x C 16.8700 -20.7200
6 C8y C 17.5000 -18.3400
7 C8y C 17.7800 -19.6700
8 C8x C 13.9300 -17.2900
9 C8y C 12.6000 -17.7100
10 C8x C 12.2500 -19.0400
11 C8x C 13.3000 -20.0200
12 C8x C 19.1100 -20.0900
13 C8x C 20.1600 -19.1800
14 C8x C 19.8800 -17.7800
15 C8x C 18.5500 -17.3600
16 C1b C 16.2718 -16.3104
17 C1b C 17.4753 -15.6512
18 C1b C 18.7026 -16.3967
19 N1y N 19.9275 -15.7254
20 C1x C 21.1515 -16.4686
21 C1x C 22.3791 -15.7955
22 C1z C 22.4100 -14.3959
23 C1x C 21.1860 -13.6527
24 C1x C 19.9584 -14.3257
25 N1y N 23.6198 -13.7329
26 C1x C 24.7888 -14.4431
27 C1x C 26.0166 -13.7703
28 C1x C 26.0478 -12.3707
29 C1x C 24.8788 -11.6605
30 C1x C 23.5810 -12.3332
31 C5a C 23.7499 -15.7544
32 N1a N 24.9621 -15.0852
33 O5a O 23.7230 -17.1500
34 X Cl 11.5863 -16.7444
35 X Cl 24.9200 -18.7600
36 O0 O 25.3400 -20.5100
37 X Cl 24.9200 -18.7600
BOND 38
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 19 24 1
28 22 25 1
29 25 26 1
30 26 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 25 30 1
35 22 31 1
36 31 32 1
37 31 33 2
38 9 34 1
BRACKET 1 23.3100 -19.3900 23.3100 -17.9900
1 25.6900 -17.9900 25.6900 -19.3900
1 2
ORIGINAL 1 35
REPEAT 1 37
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