KEGG   DRUG: Micafungin sodium
Entry
D02465                      Drug                                   

Name
Micafungin sodium (JAN/USAN);
Funguard (TN);
Mycamine (TN)
Product
  Generic
Formula
C56H70N9O23S. Na
Exact mass
1291.4203
Mol weight
1292.2563
Structure
Simcomp
Remark
Same as: C15819
Therapeutic category: 6179
ATC code: J02AX05
Chemical structure group: DG00637
Product (DG00637): D02465<JP/US> D11010<JP>
Efficacy
Antifungal, Cell wall biosynthesis inhibitor
  Disease
Candidiasis [DS:H00363]
Comment
Echinocandins
Treatment of Aspergillus and Candida fungal infections
Target
beta-1,3-glucan synthase [KO:K00706]
  Pathway
ko00500  Starch and sucrose metabolism
Interaction
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AX Other antimycotics for systemic use
     J02AX05 Micafungin
      D02465  Micafungin sodium (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antifungals
  Micafungin
   D02465  Micafungin sodium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   617  Acting mainly on mold
    6179  Others
     D02465  Micafungin sodium (JAN/USAN)
Antimicrobials [BR:br08307]
 Antifungals
  Cell membrane function inhibitor
   Echinocandin
    D02465  Micafungin sodium (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02465
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02465
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02465
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02465
Antimicrobials abbreviations [BR:br08327]
 Antifungals
  Cell membrane function inhibitor
   Echinocandin
    DG00637  Micafungin
Other DBs
CAS: 208538-73-2
PubChem: 7849521
ChEBI: 80105
ChEMBL: CHEMBL1237070 CHEMBL260117
DrugBank: DB01141
LigandBox: D02465
NIKKAJI: J1.856.181F
LinkDB
KCF data

ATOM        90
            1   C8x C    33.1145  -13.0218
            2   C8x C    33.1145  -14.4220
            3   C8y C    34.3047  -15.1221
            4   C8x C    35.5648  -14.4220
            5   C8y C    35.5648  -13.0218
            6   C8y C    34.3047  -12.3217
            7   O1a O    34.3047  -10.9215
            8   O2a O    36.7550  -12.3217
            9   C1c C    34.3047  -16.5223
            10  C1c C    33.1145  -17.2224
            11  O1a O    35.4948  -17.2224
            12  S4a S    38.1552  -12.3217
            13  O1d O    38.1552  -13.7219
            14  O1d O    38.1552  -10.9215
            15  O1d O    39.5554  -12.3217 #-
            16  C1c C    31.8543  -16.5223
            17  N1b N    31.8543  -15.1221
            18  C5a C    30.6641  -17.2224
            19  N1b N    30.6641  -18.6226
            20  O5a O    29.4740  -16.5223
            21  C1c C    29.4740  -19.3227
            22  C5a C    28.2838  -18.6226
            23  C1c C    29.4740  -20.7229
            24  C1b C    30.6641  -21.4230
            25  O1a O    28.2838  -21.4230
            26  C5a C    30.6641  -22.8232
            27  O5a O    29.4740  -23.5233
            28  N1a N    31.8543  -23.5233
            29  N1y N    27.0236  -19.3227
            30  C1y C    25.8335  -18.6226
            31  O5a O    28.2838  -17.2224
            32  C5a C    25.8335  -17.2224
            33  O5a O    27.0236  -16.5223
            34  C1y C    24.7833  -19.6027
            35  C1y C    25.3434  -20.8629
            36  C1x C    26.7436  -20.7229
            37  N1b N    24.6433  -16.5223
            38  C5a C    30.6641  -14.4220
            39  C1y C    30.6641  -13.0218
            40  N1y N    29.4740  -12.3217
            41  C5a C    28.2138  -13.0218
            42  C1c C    27.0236  -12.3217
            43  O5a O    28.2138  -14.4220
            44  C1c C    27.0236  -10.9215
            45  C1a C    28.2138  -10.2214
            46  O1a O    25.8335  -10.2214
            47  C1x C    31.7143  -12.1116
            48  C1y C    31.1542  -10.7815
            49  C1x C    29.7540  -10.9915
            50  O5a O    29.4740  -15.1221
            51  O1a O    31.8543   -9.5913
            52  N1b N    25.8335  -13.0218
            53  C5a C    24.6433  -12.3217
            54  C1c C    23.4531  -13.0218
            55  O5a O    24.6433  -10.9215
            56  N1b N    22.2630  -12.3217
            57  C1b C    23.4531  -14.4220
            58  C1c C    22.4730  -15.4021
            59  C1c C    23.2431  -16.8723
            60  O1a O    21.0728  -15.6121
            61  O1a O    22.7530  -18.2025
            62  O1a O    23.4531  -19.2527
            63  C1a C    24.6433  -22.0531
            64  O1a O    33.1145  -18.6226
            65  C5a C    21.0728  -13.0218
            66  C8y C    19.8826  -12.3217
            67  O5a O    21.0728  -14.4220
            68  C8x C    19.8826  -10.9215
            69  C8x C    18.6224  -10.2214
            70  C8y C    17.4323  -10.9215
            71  C8x C    17.4323  -12.3217
            72  C8x C    18.6224  -13.0218
            73  C8y C    16.2421  -10.2214
            74  O2x O    14.4218   -8.8912
            75  N5x N    15.8220   -8.8912
            76  C8y C    14.0018  -10.2214
            77  C8x C    15.1219  -11.0615
            78  C8y C    12.7416  -10.9215
            79  C8x C    11.5407  -10.2015
            80  C8x C    10.3168  -10.8815
            81  C8y C    10.2937  -12.2815
            82  C8x C    11.4945  -13.0015
            83  C8x C    12.7185  -12.3215
            84  O2a O     9.0806  -12.9551
            85  C1b C     7.8935  -12.2430
            86  C1b C     6.6791  -12.9174
            87  C1b C     5.4734  -12.1939
            88  C1b C     4.2447  -12.8761
            89  C1a C     3.0655  -12.1685
            90  Z   Na   41.1656  -12.3917 #+
BOND        95
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     5   8 1
            9     3   9 1
            10    9  10 1
            11    9  11 1 #Down
            12    8  12 1
            13   12  13 2
            14   12  14 2
            15   12  15 1
            16   10  16 1
            17   16  17 1 #Up
            18   16  18 1
            19   18  19 1
            20   18  20 2
            21   21  19 1 #Up
            22   21  22 1
            23   21  23 1
            24   23  24 1
            25   23  25 1 #Up
            26   24  26 1
            27   26  27 2
            28   26  28 1
            29   22  29 1
            30   29  30 1
            31   22  31 2
            32   30  32 1 #Up
            33   32  33 2
            34   30  34 1
            35   34  35 1
            36   35  36 1
            37   29  36 1
            38   32  37 1
            39   17  38 1
            40   39  38 1 #Up
            41   39  40 1
            42   40  41 1
            43   41  42 1
            44   41  43 2
            45   42  44 1
            46   44  45 1
            47   44  46 1 #Down
            48   39  47 1
            49   47  48 1
            50   48  49 1
            51   40  49 1
            52   38  50 2
            53   48  51 1 #Down
            54   42  52 1 #Up
            55   52  53 1
            56   53  54 1
            57   53  55 2
            58   54  56 1 #Down
            59   54  57 1
            60   57  58 1
            61   37  59 1
            62   58  59 1
            63   58  60 1 #Down
            64   59  61 1 #Down
            65   34  62 1 #Down
            66   35  63 1 #Down
            67   10  64 1 #Up
            68   56  65 1
            69   65  66 1
            70   65  67 2
            71   66  68 2
            72   68  69 1
            73   69  70 2
            74   70  71 1
            75   71  72 2
            76   66  72 1
            77   70  73 1
            78   74  75 1
            79   74  76 1
            80   76  77 2
            81   77  73 1
            82   75  73 2
            83   76  78 1
            84   78  79 2
            85   79  80 1
            86   80  81 2
            87   81  82 1
            88   82  83 2
            89   78  83 1
            90   81  84 1
            91   84  85 1
            92   85  86 1
            93   86  87 1
            94   87  88 1
            95   88  89 1

» Japanese version   » Back

KEGG   DRUG: Micafungin
Entry
D08218                      Drug                                   

Name
Micafungin (INN)
Formula
C56H71N9O23S
Exact mass
1269.4383
Mol weight
1270.2744
Structure
Simcomp
Remark
ATC code: J02AX05
Chemical structure group: DG00637
Product (DG00637): D02465<JP/US> D11010<JP>
Efficacy
Antifungal, Cell wall biosynthesis inhibitor
Comment
Echinocandins
Target
beta-1,3-glucan synthase [KO:K00706]
  Pathway
ko00500  Starch and sucrose metabolism
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AX Other antimycotics for systemic use
     J02AX05 Micafungin
      D08218  Micafungin (INN)
Antimicrobials [BR:br08307]
 Antifungals
  Cell membrane function inhibitor
   Echinocandin
    D08218  Micafungin (INN)
Antimicrobials abbreviations [BR:br08327]
 Antifungals
  Cell membrane function inhibitor
   Echinocandin
    DG00637  Micafungin
Other DBs
CAS: 235114-32-6
PubChem: 96024906
ChEBI: 600520
ChEMBL: CHEMBL2219519 CHEMBL457547
DrugBank: DB01141
LigandBox: D08218
LinkDB
KCF data

ATOM        89
            1   C8x C    34.5100  -34.1600
            2   C8x C    34.5100  -35.5600
            3   C8y C    35.7000  -36.2600
            4   C8x C    36.9600  -35.5600
            5   C8y C    36.9600  -34.1600
            6   C8y C    35.7000  -33.4600
            7   O1a O    35.7000  -32.0600
            8   O2a O    38.1500  -33.4600
            9   C1c C    35.7000  -37.6600
            10  C1c C    34.5100  -38.3600
            11  O1a O    36.8900  -38.3600
            12  S4a S    39.5500  -33.4600
            13  O1d O    39.5500  -34.8600
            14  O1d O    39.5500  -32.0600
            15  O1d O    40.9500  -33.4600
            16  C1c C    33.2500  -37.6600
            17  N1b N    33.2500  -36.2600
            18  C5a C    32.0600  -38.3600
            19  N1b N    32.0600  -39.7600
            20  O5a O    30.8700  -37.6600
            21  C1c C    30.8700  -40.4600
            22  C5a C    29.6800  -39.7600
            23  C1c C    30.8700  -41.8600
            24  C1b C    32.0600  -42.5600
            25  O1a O    29.6800  -42.5600
            26  C5a C    32.0600  -43.9600
            27  O5a O    30.8700  -44.6600
            28  N1a N    33.2500  -44.6600
            29  N1y N    28.4200  -40.4600
            30  C1y C    27.2300  -39.7600
            31  O5a O    29.6800  -38.3600
            32  C5a C    27.2300  -38.3600
            33  O5a O    28.4200  -37.6600
            34  C1y C    26.1800  -40.7400
            35  C1y C    26.7400  -42.0000
            36  C1x C    28.1400  -41.8600
            37  N1b N    26.0400  -37.6600
            38  C5a C    32.0600  -35.5600
            39  C1y C    32.0600  -34.1600
            40  N1y N    30.8700  -33.4600
            41  C5a C    29.6100  -34.1600
            42  C1c C    28.4200  -33.4600
            43  O5a O    29.6100  -35.5600
            44  C1c C    28.4200  -32.0600
            45  C1a C    29.6100  -31.3600
            46  O1a O    27.2300  -31.3600
            47  C1x C    33.1100  -33.2500
            48  C1y C    32.5500  -31.9200
            49  C1x C    31.1500  -32.1300
            50  O5a O    30.8700  -36.2600
            51  O1a O    33.2500  -30.7300
            52  N1b N    27.2300  -34.1600
            53  C5a C    26.0400  -33.4600
            54  C1c C    24.8500  -34.1600
            55  O5a O    26.0400  -32.0600
            56  N1b N    23.6600  -33.4600
            57  C1b C    24.8500  -35.5600
            58  C1c C    23.8700  -36.5400
            59  C1c C    24.6400  -38.0100
            60  O1a O    22.4700  -36.7500
            61  O1a O    24.1500  -39.3400
            62  O1a O    24.8500  -40.3900
            63  C1a C    26.0400  -43.1900
            64  O1a O    34.5100  -39.7600
            65  C5a C    22.4700  -34.1600
            66  C8y C    21.2800  -33.4600
            67  O5a O    22.4700  -35.5600
            68  C8x C    21.2800  -32.0600
            69  C8x C    20.0200  -31.3600
            70  C8y C    18.8300  -32.0600
            71  C8x C    18.8300  -33.4600
            72  C8x C    20.0200  -34.1600
            73  C8y C    17.6400  -31.3600
            74  O2x O    15.8200  -30.0300
            75  N5x N    17.2200  -30.0300
            76  C8y C    15.4000  -31.3600
            77  C8x C    16.5200  -32.2000
            78  C8y C    14.1400  -32.0600
            79  C8x C    12.9500  -31.3600
            80  C8x C    11.6900  -31.9900
            81  C8y C    11.6900  -33.3900
            82  C8x C    12.8800  -34.1600
            83  C8x C    14.1400  -33.4600
            84  O2a O    10.5000  -34.0900
            85  C1b C     9.3100  -33.3900
            86  C1b C     8.0500  -34.0900
            87  C1b C     6.8600  -33.3200
            88  C1b C     5.6700  -34.0200
            89  C1a C     4.4800  -33.3200
BOND        95
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     5   8 1
            9     3   9 1
            10    9  10 1
            11    9  11 1 #Down
            12    8  12 1
            13   12  13 2
            14   12  14 2
            15   12  15 1
            16   10  16 1
            17   16  17 1 #Up
            18   16  18 1
            19   18  19 1
            20   18  20 2
            21   21  19 1 #Up
            22   21  22 1
            23   21  23 1
            24   23  24 1
            25   23  25 1 #Up
            26   24  26 1
            27   26  27 2
            28   26  28 1
            29   22  29 1
            30   29  30 1
            31   22  31 2
            32   30  32 1 #Up
            33   32  33 2
            34   30  34 1
            35   34  35 1
            36   35  36 1
            37   29  36 1
            38   32  37 1
            39   17  38 1
            40   39  38 1 #Up
            41   39  40 1
            42   40  41 1
            43   41  42 1
            44   41  43 2
            45   42  44 1
            46   44  45 1
            47   44  46 1 #Down
            48   39  47 1
            49   47  48 1
            50   48  49 1
            51   40  49 1
            52   38  50 2
            53   48  51 1 #Down
            54   42  52 1 #Up
            55   52  53 1
            56   53  54 1
            57   53  55 2
            58   54  56 1 #Down
            59   54  57 1
            60   57  58 1
            61   37  59 1
            62   58  59 1
            63   58  60 1 #Down
            64   59  61 1 #Down
            65   34  62 1 #Down
            66   35  63 1 #Down
            67   10  64 1 #Up
            68   56  65 1
            69   65  66 1
            70   65  67 2
            71   66  68 2
            72   68  69 1
            73   69  70 2
            74   70  71 1
            75   71  72 2
            76   66  72 1
            77   70  73 1
            78   74  75 1
            79   74  76 1
            80   76  77 2
            81   77  73 1
            82   75  73 2
            83   76  78 1
            84   78  79 2
            85   79  80 1
            86   80  81 2
            87   81  82 1
            88   82  83 2
            89   78  83 1
            90   81  84 1
            91   84  85 1
            92   85  86 1
            93   86  87 1
            94   87  88 1
            95   88  89 1

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