KEGG   DRUG: Micafungin sodium
Entry
D02465                      Drug                                   
Name
Micafungin sodium (JAN/USAN);
Funguard (TN);
Mycamine (TN)
Product
MICAFUNGIN (Par Pharmaceutical), MYCAMINE (Astellas Pharma US), MYCAMINE (Astellas Pharma US)
  Generic
MICAFUNGIN (Apotex Corp.), MICAFUNGIN (Fresenius Kabi USA), MICAFUNGIN (Fresenius Kabi USA), MICAFUNGIN (Hikma Pharmaceuticals USA), MICAFUNGIN (Sagent Pharmaceuticals), MICAFUNGIN (Xellia Pharmaceuticals USA LLC)
Formula
C56H70N9O23S. Na
Exact mass
1291.4203
Mol weight
1292.2563
Structure
Simcomp
Remark
Same as: C15819
Therapeutic category: 6179
ATC code: J02AX05
Chemical structure group: DG00637
Product (DG00637): D02465<JP/US> D11010<JP>
Efficacy
Antifungal, Cell wall biosynthesis inhibitor
  Disease
Candidiasis [DS:H00363]
Comment
Echinocandins
Treatment of Aspergillus and Candida fungal infections
Target
beta-1,3-glucan synthase [KO:K00706]
  Pathway
ko00500  Starch and sucrose metabolism
Interaction
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AX Other antimycotics for systemic use
     J02AX05 Micafungin
      D02465  Micafungin sodium (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antifungals
  Micafungin
   D02465  Micafungin sodium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   617  Acting mainly on mold
    6179  Others
     D02465  Micafungin sodium (JAN/USAN)
Antimicrobials [BR:br08307]
 Antifungals
  Cell membrane function inhibitor
   Echinocandin
    D02465  Micafungin sodium (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02465
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02465
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02465
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02465
Antimicrobials abbreviations [BR:br08327]
 Antifungals
  Cell membrane function inhibitor
   Echinocandin
    DG00637  Micafungin
Other DBs
CAS: 208538-73-2
PubChem: 7849521
ChEBI: 80105
LigandBox: D02465
NIKKAJI: J1.856.181F
LinkDB
KCF data

ATOM        90
            1   C8x C    33.1145  -13.0218
            2   C8x C    33.1145  -14.4220
            3   C8y C    34.3047  -15.1221
            4   C8x C    35.5648  -14.4220
            5   C8y C    35.5648  -13.0218
            6   C8y C    34.3047  -12.3217
            7   O1a O    34.3047  -10.9215
            8   O2a O    36.7550  -12.3217
            9   C1c C    34.3047  -16.5223
            10  C1c C    33.1145  -17.2224
            11  O1a O    35.4948  -17.2224
            12  S4a S    38.1552  -12.3217
            13  O1d O    38.1552  -13.7219
            14  O1d O    38.1552  -10.9215
            15  O1d O    39.5554  -12.3217 #-
            16  C1c C    31.8543  -16.5223
            17  N1b N    31.8543  -15.1221
            18  C5a C    30.6641  -17.2224
            19  N1b N    30.6641  -18.6226
            20  O5a O    29.4740  -16.5223
            21  C1c C    29.4740  -19.3227
            22  C5a C    28.2838  -18.6226
            23  C1c C    29.4740  -20.7229
            24  C1b C    30.6641  -21.4230
            25  O1a O    28.2838  -21.4230
            26  C5a C    30.6641  -22.8232
            27  O5a O    29.4740  -23.5233
            28  N1a N    31.8543  -23.5233
            29  N1y N    27.0236  -19.3227
            30  C1y C    25.8335  -18.6226
            31  O5a O    28.2838  -17.2224
            32  C5a C    25.8335  -17.2224
            33  O5a O    27.0236  -16.5223
            34  C1y C    24.7833  -19.6027
            35  C1y C    25.3434  -20.8629
            36  C1x C    26.7436  -20.7229
            37  N1b N    24.6433  -16.5223
            38  C5a C    30.6641  -14.4220
            39  C1y C    30.6641  -13.0218
            40  N1y N    29.4740  -12.3217
            41  C5a C    28.2138  -13.0218
            42  C1c C    27.0236  -12.3217
            43  O5a O    28.2138  -14.4220
            44  C1c C    27.0236  -10.9215
            45  C1a C    28.2138  -10.2214
            46  O1a O    25.8335  -10.2214
            47  C1x C    31.7143  -12.1116
            48  C1y C    31.1542  -10.7815
            49  C1x C    29.7540  -10.9915
            50  O5a O    29.4740  -15.1221
            51  O1a O    31.8543   -9.5913
            52  N1b N    25.8335  -13.0218
            53  C5a C    24.6433  -12.3217
            54  C1c C    23.4531  -13.0218
            55  O5a O    24.6433  -10.9215
            56  N1b N    22.2630  -12.3217
            57  C1b C    23.4531  -14.4220
            58  C1c C    22.4730  -15.4021
            59  C1c C    23.2431  -16.8723
            60  O1a O    21.0728  -15.6121
            61  O1a O    22.7530  -18.2025
            62  O1a O    23.4531  -19.2527
            63  C1a C    24.6433  -22.0531
            64  O1a O    33.1145  -18.6226
            65  C5a C    21.0728  -13.0218
            66  C8y C    19.8826  -12.3217
            67  O5a O    21.0728  -14.4220
            68  C8x C    19.8826  -10.9215
            69  C8x C    18.6224  -10.2214
            70  C8y C    17.4323  -10.9215
            71  C8x C    17.4323  -12.3217
            72  C8x C    18.6224  -13.0218
            73  C8y C    16.2421  -10.2214
            74  O2x O    14.4218   -8.8912
            75  N5x N    15.8220   -8.8912
            76  C8y C    14.0018  -10.2214
            77  C8x C    15.1219  -11.0615
            78  C8y C    12.7416  -10.9215
            79  C8x C    11.5407  -10.2015
            80  C8x C    10.3168  -10.8815
            81  C8y C    10.2937  -12.2815
            82  C8x C    11.4945  -13.0015
            83  C8x C    12.7185  -12.3215
            84  O2a O     9.0806  -12.9551
            85  C1b C     7.8935  -12.2430
            86  C1b C     6.6791  -12.9174
            87  C1b C     5.4734  -12.1939
            88  C1b C     4.2447  -12.8761
            89  C1a C     3.0655  -12.1685
            90  Z   Na   41.1656  -12.3917 #+
BOND        95
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     5   8 1
            9     3   9 1
            10    9  10 1
            11    9  11 1 #Down
            12    8  12 1
            13   12  13 2
            14   12  14 2
            15   12  15 1
            16   10  16 1
            17   16  17 1 #Up
            18   16  18 1
            19   18  19 1
            20   18  20 2
            21   21  19 1 #Up
            22   21  22 1
            23   21  23 1
            24   23  24 1
            25   23  25 1 #Up
            26   24  26 1
            27   26  27 2
            28   26  28 1
            29   22  29 1
            30   29  30 1
            31   22  31 2
            32   30  32 1 #Up
            33   32  33 2
            34   30  34 1
            35   34  35 1
            36   35  36 1
            37   29  36 1
            38   32  37 1
            39   17  38 1
            40   39  38 1 #Up
            41   39  40 1
            42   40  41 1
            43   41  42 1
            44   41  43 2
            45   42  44 1
            46   44  45 1
            47   44  46 1 #Down
            48   39  47 1
            49   47  48 1
            50   48  49 1
            51   40  49 1
            52   38  50 2
            53   48  51 1 #Down
            54   42  52 1 #Up
            55   52  53 1
            56   53  54 1
            57   53  55 2
            58   54  56 1 #Down
            59   54  57 1
            60   57  58 1
            61   37  59 1
            62   58  59 1
            63   58  60 1 #Down
            64   59  61 1 #Down
            65   34  62 1 #Down
            66   35  63 1 #Down
            67   10  64 1 #Up
            68   56  65 1
            69   65  66 1
            70   65  67 2
            71   66  68 2
            72   68  69 1
            73   69  70 2
            74   70  71 1
            75   71  72 2
            76   66  72 1
            77   70  73 1
            78   74  75 1
            79   74  76 1
            80   76  77 2
            81   77  73 1
            82   75  73 2
            83   76  78 1
            84   78  79 2
            85   79  80 1
            86   80  81 2
            87   81  82 1
            88   82  83 2
            89   78  83 1
            90   81  84 1
            91   84  85 1
            92   85  86 1
            93   86  87 1
            94   87  88 1
            95   88  89 1

» Japanese version   » Back

KEGG   DRUG: Micafungin
Entry
D08218                      Drug                                   
Name
Micafungin (INN)
Formula
C56H71N9O23S
Exact mass
1269.4383
Mol weight
1270.2744
Structure
Simcomp
Remark
ATC code: J02AX05
Chemical structure group: DG00637
Product (DG00637): D02465<JP/US> D11010<JP>
Efficacy
Antifungal, Cell wall biosynthesis inhibitor
Comment
Echinocandins
Target
beta-1,3-glucan synthase [KO:K00706]
  Pathway
ko00500  Starch and sucrose metabolism
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AX Other antimycotics for systemic use
     J02AX05 Micafungin
      D08218  Micafungin (INN)
Antimicrobials [BR:br08307]
 Antifungals
  Cell membrane function inhibitor
   Echinocandin
    D08218  Micafungin (INN)
Antimicrobials abbreviations [BR:br08327]
 Antifungals
  Cell membrane function inhibitor
   Echinocandin
    DG00637  Micafungin
Other DBs
CAS: 235114-32-6
PubChem: 96024906
ChEBI: 600520
LigandBox: D08218
LinkDB
KCF data

ATOM        89
            1   C8x C    34.5100  -34.1600
            2   C8x C    34.5100  -35.5600
            3   C8y C    35.7000  -36.2600
            4   C8x C    36.9600  -35.5600
            5   C8y C    36.9600  -34.1600
            6   C8y C    35.7000  -33.4600
            7   O1a O    35.7000  -32.0600
            8   O2a O    38.1500  -33.4600
            9   C1c C    35.7000  -37.6600
            10  C1c C    34.5100  -38.3600
            11  O1a O    36.8900  -38.3600
            12  S4a S    39.5500  -33.4600
            13  O1d O    39.5500  -34.8600
            14  O1d O    39.5500  -32.0600
            15  O1d O    40.9500  -33.4600
            16  C1c C    33.2500  -37.6600
            17  N1b N    33.2500  -36.2600
            18  C5a C    32.0600  -38.3600
            19  N1b N    32.0600  -39.7600
            20  O5a O    30.8700  -37.6600
            21  C1c C    30.8700  -40.4600
            22  C5a C    29.6800  -39.7600
            23  C1c C    30.8700  -41.8600
            24  C1b C    32.0600  -42.5600
            25  O1a O    29.6800  -42.5600
            26  C5a C    32.0600  -43.9600
            27  O5a O    30.8700  -44.6600
            28  N1a N    33.2500  -44.6600
            29  N1y N    28.4200  -40.4600
            30  C1y C    27.2300  -39.7600
            31  O5a O    29.6800  -38.3600
            32  C5a C    27.2300  -38.3600
            33  O5a O    28.4200  -37.6600
            34  C1y C    26.1800  -40.7400
            35  C1y C    26.7400  -42.0000
            36  C1x C    28.1400  -41.8600
            37  N1b N    26.0400  -37.6600
            38  C5a C    32.0600  -35.5600
            39  C1y C    32.0600  -34.1600
            40  N1y N    30.8700  -33.4600
            41  C5a C    29.6100  -34.1600
            42  C1c C    28.4200  -33.4600
            43  O5a O    29.6100  -35.5600
            44  C1c C    28.4200  -32.0600
            45  C1a C    29.6100  -31.3600
            46  O1a O    27.2300  -31.3600
            47  C1x C    33.1100  -33.2500
            48  C1y C    32.5500  -31.9200
            49  C1x C    31.1500  -32.1300
            50  O5a O    30.8700  -36.2600
            51  O1a O    33.2500  -30.7300
            52  N1b N    27.2300  -34.1600
            53  C5a C    26.0400  -33.4600
            54  C1c C    24.8500  -34.1600
            55  O5a O    26.0400  -32.0600
            56  N1b N    23.6600  -33.4600
            57  C1b C    24.8500  -35.5600
            58  C1c C    23.8700  -36.5400
            59  C1c C    24.6400  -38.0100
            60  O1a O    22.4700  -36.7500
            61  O1a O    24.1500  -39.3400
            62  O1a O    24.8500  -40.3900
            63  C1a C    26.0400  -43.1900
            64  O1a O    34.5100  -39.7600
            65  C5a C    22.4700  -34.1600
            66  C8y C    21.2800  -33.4600
            67  O5a O    22.4700  -35.5600
            68  C8x C    21.2800  -32.0600
            69  C8x C    20.0200  -31.3600
            70  C8y C    18.8300  -32.0600
            71  C8x C    18.8300  -33.4600
            72  C8x C    20.0200  -34.1600
            73  C8y C    17.6400  -31.3600
            74  O2x O    15.8200  -30.0300
            75  N5x N    17.2200  -30.0300
            76  C8y C    15.4000  -31.3600
            77  C8x C    16.5200  -32.2000
            78  C8y C    14.1400  -32.0600
            79  C8x C    12.9500  -31.3600
            80  C8x C    11.6900  -31.9900
            81  C8y C    11.6900  -33.3900
            82  C8x C    12.8800  -34.1600
            83  C8x C    14.1400  -33.4600
            84  O2a O    10.5000  -34.0900
            85  C1b C     9.3100  -33.3900
            86  C1b C     8.0500  -34.0900
            87  C1b C     6.8600  -33.3200
            88  C1b C     5.6700  -34.0200
            89  C1a C     4.4800  -33.3200
BOND        95
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     5   8 1
            9     3   9 1
            10    9  10 1
            11    9  11 1 #Down
            12    8  12 1
            13   12  13 2
            14   12  14 2
            15   12  15 1
            16   10  16 1
            17   16  17 1 #Up
            18   16  18 1
            19   18  19 1
            20   18  20 2
            21   21  19 1 #Up
            22   21  22 1
            23   21  23 1
            24   23  24 1
            25   23  25 1 #Up
            26   24  26 1
            27   26  27 2
            28   26  28 1
            29   22  29 1
            30   29  30 1
            31   22  31 2
            32   30  32 1 #Up
            33   32  33 2
            34   30  34 1
            35   34  35 1
            36   35  36 1
            37   29  36 1
            38   32  37 1
            39   17  38 1
            40   39  38 1 #Up
            41   39  40 1
            42   40  41 1
            43   41  42 1
            44   41  43 2
            45   42  44 1
            46   44  45 1
            47   44  46 1 #Down
            48   39  47 1
            49   47  48 1
            50   48  49 1
            51   40  49 1
            52   38  50 2
            53   48  51 1 #Down
            54   42  52 1 #Up
            55   52  53 1
            56   53  54 1
            57   53  55 2
            58   54  56 1 #Down
            59   54  57 1
            60   57  58 1
            61   37  59 1
            62   58  59 1
            63   58  60 1 #Down
            64   59  61 1 #Down
            65   34  62 1 #Down
            66   35  63 1 #Down
            67   10  64 1 #Up
            68   56  65 1
            69   65  66 1
            70   65  67 2
            71   66  68 2
            72   68  69 1
            73   69  70 2
            74   70  71 1
            75   71  72 2
            76   66  72 1
            77   70  73 1
            78   74  75 1
            79   74  76 1
            80   76  77 2
            81   77  73 1
            82   75  73 2
            83   76  78 1
            84   78  79 2
            85   79  80 1
            86   80  81 2
            87   81  82 1
            88   82  83 2
            89   78  83 1
            90   81  84 1
            91   84  85 1
            92   85  86 1
            93   86  87 1
            94   87  88 1
            95   88  89 1

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