KEGG   DRUG: Tazobactam and piperacillin
Entry
D02505            Mixture   Drug                                   
Name
Tazobactam and piperacillin (JP18);
Piperacillin sodium and tazobactam;
Tazocin (TN);
Zosyn (TN)
  Abbr
TZP
Product
ZOSYN (Baxter Healthcare Corporation), ZOSYN (Wyeth Pharmaceuticals LLC)
  Generic
PIPERACILLIN AND TAZOBACTAM (Apotex Corp.), PIPERACILLIN AND TAZOBACTAM (Apotex Corp.), PIPERACILLIN AND TAZOBACTAM (Armas Pharmaceuticals), PIPERACILLIN AND TAZOBACTAM (Armas Pharmaceuticals), PIPERACILLIN AND TAZOBACTAM (BluePoint Laboratories), PIPERACILLIN AND TAZOBACTAM (Civica), PIPERACILLIN AND TAZOBACTAM (Eugia US LLC), PIPERACILLIN AND TAZOBACTAM (Eugia US LLC), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Fresenius Kabi USA), PIPERACILLIN AND TAZOBACTAM (Hospira), PIPERACILLIN AND TAZOBACTAM (Hospira), PIPERACILLIN AND TAZOBACTAM (Hospira), PIPERACILLIN AND TAZOBACTAM (Provepharm), PIPERACILLIN AND TAZOBACTAM (Provepharm), PIPERACILLIN AND TAZOBACTAM (Sandoz), PIPERACILLIN AND TAZOBACTAM (Sandoz), PIPERACILLIN AND TAZOBACTAM (Sandoz), PIPERACILLIN AND TAZOBACTAM (Shandong Anxin Pharmaceutical), PIPERACILLIN AND TAZOBACTAM (Shandong Anxin Pharmaceutical), PIPERACILLIN AND TAZOBACTAM (Steriscience Specialties Private Limited), PIPERACILLIN AND TAZOBACTAM (WG Critical Care), PIPERACILLIN AND TAZOBACTAM (WG Critical Care), PIPERACILLIN AND TAZOBACTAM (Wockhardt USA LLC.), PIPERACILLIN AND TAZOBACTAM (Wockhardt USA LLC.), PIPERACILLIN SODIUM AND TAZOBACTAM SODIUM (Xellia Pharmaceuticals USA LLC), PIPERACILLIN, TAZOBACTAM (Sagent Pharmaceuticals), PIPERACILLIN, TAZOBACTAM (Sagent Pharmaceuticals)
Formula
C23H26N5O7S. C10H12N4O5S. Na
Exact mass
839.1979
Mol weight
839.8277
Structure
Component
(Piperacillin sodium [DR:D00466] | Piperacillin hydrate [DR:D02251] | Piperacillin [DR:D08380]), (Tazobactam [DR:D00660] | Tazobactam sodium [DR:D03707])
Remark
Therapeutic category: 6139
ATC code: J01CR05 J01RA01
Product: D02505<JP/US>
Efficacy
Antibacterial
Interaction
Structure map
map07011  Penicillins
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS
    J01CR Combinations of penicillins, incl. beta-lactamase inhibitors
     J01CR05 Piperacillin and beta-lactamase inhibitor
      D02505  Tazobactam and piperacillin (JP18) <JP/US>
   J01R COMBINATIONS OF ANTIBACTERIALS
    J01RA Combinations of antibacterials
     J01RA01 Penicillins, combinations with other antibacterials
      D02505  Tazobactam and piperacillin (JP18) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Penicillins
   Piperacillin Sodium/ Tazobactam Sodium
    D02505  Tazobactam and piperacillin (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6139  Others
     D02505  Tazobactam and piperacillin (JP18)
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Extended spectrum penicillin
    D02505  Tazobactam and piperacillin (JP18) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Extended spectrum penicillin
    D02505  Tazobactam and piperacillin (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02505  Tazobactam and piperacillin for injection
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02505
Other DBs
PubChem: 17396679
LigandBox: D02505
LinkDB
KCF data

ATOM        57
            1   C1y C    13.8347  -20.3124
            2   C5x C    13.8347  -21.7118
            3   N1y N    15.2341  -21.7118
            4   C1y C    15.2341  -20.3124
            5   C1y C    16.5637  -22.1316
            6   C1z C    17.4032  -21.0122
            7   S2x S    16.5637  -19.8927
            8   C1a C    18.3828  -21.9917
            9   C1a C    18.3828  -20.0325
            10  C6a C    17.0534  -23.5309
            11  O6a O    18.4527  -23.5309 #-
            12  O6a O    16.2138  -24.6504
            13  N1b N    12.6453  -19.6128
            14  C5a C    11.4559  -20.3124
            15  O5x O    12.6453  -22.4115
            16  O5a O    11.4559  -21.7118
            17  C1c C    10.1965  -19.6128
            18  C8y C    10.1965  -18.2133
            19  C8x C    11.4559  -17.5137
            20  C8x C    11.4559  -16.1143
            21  C8x C    10.1965  -15.4145
            22  C8x C     9.0069  -16.1143
            23  C8x C     9.0069  -17.5137
            24  N1b N     9.0069  -20.3124
            25  C5a C     7.8175  -19.6128
            26  O5a O     7.8175  -18.2133
            27  N1y N     6.5724  -20.3245
            28  C5x C     5.3574  -19.6230
            29  C5x C     4.1423  -20.3245
            30  N1y N     4.1423  -21.7275
            31  C1x C     5.3574  -22.4290
            32  C1x C     6.5724  -21.7275
            33  C1b C     2.9252  -22.4301
            34  C1a C     1.7449  -21.7486
            35  O5x O     2.9441  -19.6328
            36  O5x O     5.3572  -18.2419
            37  Z   Na   20.0064  -23.5033 #+
            38  C1x C    21.9422  -20.1909
            39  C5x C    21.9422  -21.5882
            40  N1y N    23.3397  -21.5882
            41  C1y C    23.3397  -20.1909
            42  C1y C    24.6685  -22.0200
            43  C1z C    25.4898  -20.8896
            44  S2x S    24.6685  -19.7591
            45  C1a C    26.4777  -21.8776
            46  C1b C    26.4777  -19.9016
            47  C6a C    25.0964  -23.3371
            48  O6a O    26.4938  -23.3371
            49  O6a O    24.2727  -24.4710
            50  O3c O    24.3076  -18.4122
            51  O3c O    25.6546  -18.7731
            52  N4y N    27.8742  -19.9016
            53  C8x C    28.7046  -21.0445
            54  C8x C    30.0481  -20.6080
            55  N5x N    30.0482  -19.1954
            56  N5x N    28.7047  -18.7588
            57  O5x O    20.7298  -22.2882
BOND        61
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     1   4 1
            5     3   5 1
            6     5   6 1
            7     6   7 1
            8     4   7 1
            9     6   8 1
            10    6   9 1
            11    5  10 1 #Down
            12   10  11 1
            13   10  12 2
            14    1  13 1 #Up
            15   13  14 1
            16    2  15 2
            17   14  16 2
            18   14  17 1
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26   24  25 1
            27   17  24 1 #Up
            28   25  26 2
            29   25  27 1
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 1
            34   31  32 1
            35   27  32 1
            36   30  33 1
            37   33  34 1
            38   29  35 2
            39   28  36 2
            40   38  39 1
            41   39  40 1
            42   40  41 1
            43   38  41 1
            44   40  42 1
            45   42  43 1
            46   43  44 1
            47   41  44 1
            48   43  45 1 #Down
            49   43  46 1
            50   42  47 1 #Down
            51   47  48 1
            52   47  49 2
            53   44  50 2
            54   44  51 2
            55   46  52 1
            56   52  53 1
            57   53  54 2
            58   54  55 1
            59   55  56 2
            60   52  56 1
            61   39  57 2

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