KEGG   DRUG: Lomerizine hydrochloride
Entry
D02633                      Drug                                   
Name
Lomerizine hydrochloride (JAN);
Terranas (TN)
Formula
C27H30F2N2O3. 2HCl
Exact mass
540.1758
Mol weight
541.4574
Structure
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
Remark
Therapeutic category: 2190
Product: D02633<JP>
Efficacy
Antimigraine, Vasoconstriction suppressant
Target
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04020  Calcium signaling pathway
Interaction
Structure map
map07036  Calcium channel blocking drugs
map07048  Antimigraines
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D02633  Lomerizine hydrochloride (JAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   D02633  Lomerizine hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   D02633  Lomerizine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-T
     D02633  Lomerizine hydrochloride (JAN) <JP>
Other DBs
CAS: 101477-54-7
PubChem: 17396803
LigandBox: D02633
NIKKAJI: J247.629K
LinkDB
KCF data

ATOM        36
            1   X   Cl   42.1446  -18.7935
            2   C8x C    30.5200  -20.7900
            3   C8y C    30.5200  -22.1900
            4   C8x C    31.7324  -22.8900
            5   C8x C    32.9449  -22.1900
            6   C8y C    32.9449  -20.7900
            7   C8x C    31.7324  -20.0900
            8   C8x C    35.3697  -22.1900
            9   C8y C    35.3697  -20.7900
            10  C1c C    34.1573  -20.0900
            11  N1y N    34.1573  -18.6900
            12  C1x C    35.3718  -17.9888
            13  C1x C    35.3718  -16.5888
            14  N1y N    34.1593  -15.8888
            15  C1x C    32.9449  -16.5900
            16  C1x C    32.9449  -17.9900
            17  C8x C    36.5822  -22.8900
            18  C8y C    37.7946  -22.1900
            19  C8x C    37.7946  -20.7900
            20  C8x C    36.5822  -20.0900
            21  C1b C    34.1593  -14.4900
            22  C8y C    35.3723  -13.7897
            23  C8y C    36.5680  -14.4802
            24  C8y C    37.7805  -13.7804
            25  C8y C    37.7807  -12.3804
            26  C8x C    36.5849  -11.6898
            27  C8x C    35.3724  -12.3897
            28  X   F    39.0111  -22.8923
            29  X   F    29.3076  -22.8900
            30  O2a O    39.0033  -11.6745
            31  C1a C    40.2123  -12.3726
            32  O2a O    39.0116  -14.4914
            33  C1a C    40.2084  -13.8004
            34  O2a O    36.5681  -15.8897
            35  C1a C    37.7594  -16.5778
            36  X   Cl   42.1446  -18.7935
BOND        37
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   11  16 1
            17    8  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21    9  20 2
            22   14  21 1
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1
            30   18  28 1
            31    3  29 1
            32   25  30 1
            33   30  31 1
            34   24  32 1
            35   32  33 1
            36   23  34 1
            37   34  35 1
BRACKET     1    40.3200  -19.7400   40.3200  -17.7100
            1    43.0500  -17.7100   43.0500  -19.7400
            1  2
 ORIGINAL  1    1
 REPEAT    1   36

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