KEGG   DRUG: Bimatoprost
Entry
D02724                      Drug                                   
Name
Bimatoprost (JAN/USAN/INN);
Lumigan (TN);
Latisse (TN)
Product
DURYSTA (Allergan), LATISSE (Allergan), LUMIGAN (Allergan)
  Generic
BIMATOPROST (Alembic Pharmaceuticals Limited), BIMATOPROST (Alembic Pharmaceuticals Limited), BIMATOPROST (Alembic Pharmaceuticals), BIMATOPROST (Alembic Pharmaceuticals), BIMATOPROST (Apotex Corp.), BIMATOPROST (Aurobindo Pharma Limited), BIMATOPROST (Fosun Pharma USA), BIMATOPROST (Gland Pharma Limited), BIMATOPROST (Micro Labs Limited), BIMATOPROST (NuCare Pharmaceuticals), BIMATOPROST (NuCare Pharmaceuticals), BIMATOPROST (Sandoz), BIMATOPROST (Somerset Therapeutics)
Formula
C25H37NO4
Exact mass
415.2723
Mol weight
415.56
Structure
Class
Hormonal agent
 DG01961  Prostaglandin derivative
  DG01960  Prostaglandin F derivative
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Therapeutic category: 1319 2679
ATC code: S01EE03
Chemical structure group: DG03267
Product (DG03267): D02724<JP/US>
Efficacy
Antiglaucoma, Eyelash growth stimulant
  Disease
Open angle glaucoma [DS:H00612]
Comment
Prostamide analog
Target
PTGFR [HSA:5737] [KO:K04262]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07035  Prostaglandins
map07054  Antiglaucoma agents
map07228  Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EE Prostaglandin analogues
     S01EE03 Bimatoprost
      D02724  Bimatoprost (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatological Agents, Other
   Dermatological Agents, Miscellaneous
    Bimatoprost
     D02724  Bimatoprost (JAN/USAN/INN)
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Prostaglandin and Prostamide Analogs, Ophthalmic
    Bimatoprost
     D02724  Bimatoprost (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D02724  Bimatoprost (JAN/USAN/INN)
 2  Agents affecting individual organs
  26  Epidermides
   267  Hair remedies
    2679  Others
     D02724  Bimatoprost (JAN/USAN/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01961  Prostaglandin derivative
   DG01960  Prostaglandin F derivative
    DG03267  Bimatoprost
     D02724  Bimatoprost
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG03267  Bimatoprost
    D02724  Bimatoprost
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D02724  Bimatoprost
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    PTGFR
     D02724  Bimatoprost (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02724
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02724
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02724
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02724
Drug groups [BR:br08330]
 Hormonal agent
  DG01961  Prostaglandin derivative
   DG01960  Prostaglandin F derivative
    DG03267  Bimatoprost
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG03267  Bimatoprost
Other DBs
CAS: 155206-00-1
PubChem: 17396891
ChEBI: 51230
PDB-CCD: 15M[PDBj]
LigandBox: D02724
LinkDB
KCF data

ATOM        30
            1   C1y C    11.4800  -17.9900
            2   C1y C    11.4800  -16.5900
            3   C1y C    10.1485  -16.1574
            4   C1x C     9.3256  -17.2900
            5   C1y C    10.1485  -18.4226
            6   O1a O     9.7197  -14.8378
            7   O1a O     9.7197  -19.7422
            8   C1b C    12.6924  -15.8900
            9   C2b C    13.9049  -16.5900
            10  C2b C    12.6924  -18.6900
            11  C2b C    13.9049  -17.9900
            12  C1c C    15.1173  -18.6900
            13  C1b C    16.3297  -17.9900
            14  C1b C    17.5422  -18.6900
            15  C2b C    15.3049  -16.5900
            16  C1b C    16.5424  -15.8900
            17  C1b C    17.7549  -16.5900
            18  C1b C    18.9673  -15.8900
            19  C5a C    20.1797  -16.5900
            20  N1b N    21.3922  -15.8900
            21  C1b C    22.6046  -16.5900
            22  O1a O    15.1173  -20.0900
            23  C8y C    17.5422  -20.0900
            24  C8x C    16.3508  -20.7781
            25  C8x C    16.3510  -22.1781
            26  C8x C    17.5636  -22.8779
            27  C8x C    18.7550  -22.1898
            28  C8x C    18.7547  -20.7898
            29  O5a O    20.1797  -17.9899
            30  C1a C    23.8211  -15.8877
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     3   6 1 #Down
            7     5   7 1 #Down
            8     2   8 1 #Down
            9     8   9 1
            10    1  10 1 #Up
            11   10  11 2
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    9  15 2
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   12  22 1 #Down
            23   14  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   23  28 1
            30   19  29 2
            31   21  30 1

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