KEGG   DRUG: AlteplaseHelp
Entry
D02837                      Drug                                   

Name
Alteplase (USP/INN);
Alteplase (genetical recombination) (JAN);
Activase (TN)
Product
Formula
C2569H3894N746O781S40
Exact mass
58969.675
Mol weight
59007.5363
Sequence
SYQVICRDEK TQMIYQQHQS WLRPVLRSNR VEYCWCNSGR AQCHSVPVKS CSEPRCFNGG
TCQQALYFSD FVCQCPEGFA GKCCEIDTRA TCYEDQGISY RGTWSTAESG AECTNWNSSA
LAQKPYSGRR PDAIRLGLGN HNYCRNPDRD SKPWCYVFKA GKYSSEFCST PACSEGNSDC
YFGNGSAYRG THSLTESGAS CLPWNSMILI GKVYTAQNPS AQALGLGKHN YCRNPDGDAK
PWCHVLKNRR LTWEYCDVPS CSTCGLRQYS QPQFRIKGGL FADIASHPWQ AAIFAKHRRS
PGERFLCGGI LISSCWILSA AHCFQERFPP HHLTVILGRT YRVVPGEEEQ KFEVEKYIVH
KEFDDDTYDN DIALLQLKSD SSRCAQESSV VRTVCLPPAD LQLPDWTECE LSGYGKHEAL
SPFYSERLKE AHVRLYPSSR CTSQHLLNRT VTDNMLCAGD TRSGGPQANL HDACQGDSGG
PLVCLNDGRM TLVGIISWGL GCGQKDVPGV YTKVTNYLDW IRDNMRP
(Disulfide bridge:6-36, 34-43, 51-62, 56-73, 75-84, 92-173, 113-155, 144-168, 180-261, 201-243, 232-256, 264-395, 307-323, 315-384, 409-484, 441-457, 474-502)
  Type
Peptide
Class
Cardiovascular agent
 DG01950  Antithrombotic agent
  DG01707  Fibrinolytic
   DG01664  Tissue plasminogen activator (t-PA)
 DG01707  Fibrinolytic
  DG01664  Tissue plasminogen activator (t-PA)
Remark
Therapeutic category: 3959
ATC code: B01AD02 S01XA13
Product: D02837<JP/US>
Efficacy
Thrombolytic, Tissue plasminogen activator (t-PA)
Comment
recombinant tissue plasminogen activator (rt-PA) [HSA:5327] [KO:K01343] [EC:3.4.21.68]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AD Enzymes
     B01AD02 Alteplase
      D02837  Alteplase (USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01X OTHER OPHTHALMOLOGICALS
    S01XA Other ophthalmologicals
     S01XA13 Alteplase
      D02837  Alteplase (USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D02837  Alteplase (USP/INN); Alteplase (genetical recombination) (JAN)
BRITE hierarchy
Other DBs
CAS: 105857-23-6
PubChem: 17396994
DrugBank: DB00009
NIKKAJI: J2.287.934K
LinkDB All DBs

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