KEGG   DRUG: Alvimopan
Entry
D02878                      Drug                                   
Name
Alvimopan (USAN);
Alvimopan dihydrate;
Entereg (TN)
Product
ENTEREG (Merck Sharp & Dohme LLC)
  Generic
ALVIMOPAN (Actavis Pharma), ALVIMOPAN (Golden State Medical Supply), ALVIMOPAN (Hikma Pharmaceuticals USA), ALVIMOPAN (Par Pharmaceutical)
Formula
C25H32N2O4. 2H2O
Exact mass
460.2573
Mol weight
460.5631
Structure
Class
Analgesic
 DG01586  Opioid receptor antagonist
Gastrointestinal agent
 DG01770  Laxative
Remark
ATC code: A06AH02
Product: D02878<US>
Efficacy
Laxative, Opioid receptor antagonist
Comment
Treatment of opioid-induced bowel dysfunction, opioid-induced nausea and vomiting, postoperative ileus, idiopathic constipation, and irritable bowel syndrome
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonists
     A06AH02 Alvimopan
      D02878  Alvimopan (USAN) <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Alvimopan
    D02878  Alvimopan (USAN)
Drug groups [BR:br08330]
 Analgesic
  DG01586  Opioid receptor antagonist
   D02878  Alvimopan
 Gastrointestinal agent
  DG01770  Laxative
   D02878  Alvimopan
Drug classes [BR:br08332]
 Gastrointestinal agent
  DG01770  Laxative
   D02878  Alvimopan
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D02878  Alvimopan (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02878
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02878
Other DBs
CAS: 170098-38-1
PubChem: 17397035
LigandBox: D02878
LinkDB
KCF data

ATOM        33
            1   O0  O    38.7802  -16.8251
            2   C1z C    23.1358  -16.4305
            3   C1y C    23.1358  -17.8140
            4   C1x C    24.3339  -18.5057
            5   N1y N    25.5321  -17.8140
            6   C1x C    25.5321  -16.4305
            7   C1x C    24.3339  -15.7387
            8   C1a C    21.9377  -18.5057
            9   C1b C    26.7302  -18.5057
            10  C1c C    27.9283  -17.8140
            11  C1b C    27.9283  -16.4305
            12  C5a C    29.1265  -18.5057
            13  N1b N    30.3246  -17.8140
            14  C1b C    31.5228  -18.5057
            15  C6a C    32.7210  -17.8140
            16  O5a O    29.1265  -19.8892
            17  O6a O    33.9191  -18.5057
            18  O6a O    32.7210  -16.4305
            19  C8x C    30.3246  -16.4305
            20  C8y C    29.1264  -15.7387
            21  C8x C    31.5228  -15.7387
            22  C8x C    31.5228  -14.3552
            23  C8x C    30.3245  -13.6635
            24  C8x C    29.1264  -14.3552
            25  C8y C    21.9574  -15.7502
            26  C8x C    21.9574  -14.3502
            27  C8x C    20.7450  -13.6502
            28  C8x C    19.5325  -14.3502
            29  C8y C    19.5326  -15.7503
            30  C8x C    20.7450  -16.4502
            31  O1a O    18.3183  -16.4513
            32  C1a C    23.1358  -15.0305
            33  O0  O    38.7802  -16.8251
BOND        33
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     2   7 1
            7     3   8 1 #Down
            8     5   9 1
            9     9  10 1
            10   10  12 1
            11   12  13 1
            12   13  14 1
            13   14  15 1
            14   10  11 1 #Down
            15   12  16 2
            16   15  17 1
            17   15  18 2
            18   20  11 1
            19   20  19 2
            20   19  21 1
            21   21  22 2
            22   22  23 1
            23   23  24 2
            24   20  24 1
            25    2  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   28  29 1
            30   29  30 2
            31   25  30 1
            32   29  31 1
            33    2  32 1 #Up
BRACKET     1    36.5400  -17.6400   36.5400  -16.1000
            1    39.6200  -16.1000   39.6200  -17.6400
            1  2
 ORIGINAL  1    1
 REPEAT    1   33

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