KEGG   DRUG: AlvimopanHelp
Entry
D02878                      Drug                                   

Name
Alvimopan (USAN);
Alvimopan dihydrate;
Entereg (TN)
Product
Formula
C25H32N2O4. 2H2O
Exact mass
460.2573
Mol weight
460.5631
Structure
Mol fileKCF fileDB search
Class
Gastrointestinal agent
 DG01770  Laxative
  DG01768  Opioid-induced laxative
Analgesic
 DG01586  Opioid receptor antagonist
Remark
ATC code: A06AH02
Product: D02878<US>
Efficacy
Laxative, Opioid receptor antagonist
Comment
Treatment of opioid-induced bowel dysfunction, opioid-induced nausea and vomiting, postoperative ileus, idiopathic constipation, and irritable bowel syndrome
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonist
     A06AH02 Alvimopan
      D02878  Alvimopan (USAN) <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Alvimopan
    D02878  Alvimopan (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D02878  Alvimopan (USAN) <US>
Drug classes of therapeutic agents [br08360.html]
 Gastrointestinal agents
  D02878
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02878
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02878
BRITE hierarchy
Other DBs
CAS: 170098-38-1
PubChem: 17397035
LigandBox: D02878
LinkDB All DBs
KCF data Show

ATOM        33
            1   O0  O    38.7802  -16.8251
            2   C1z C    23.1358  -16.4305
            3   C1y C    23.1358  -17.8140
            4   C1x C    24.3339  -18.5057
            5   N1y N    25.5321  -17.8140
            6   C1x C    25.5321  -16.4305
            7   C1x C    24.3339  -15.7387
            8   C1a C    21.9377  -18.5057
            9   C1b C    26.7302  -18.5057
            10  C1c C    27.9283  -17.8140
            11  C1b C    27.9283  -16.4305
            12  C5a C    29.1265  -18.5057
            13  N1b N    30.3246  -17.8140
            14  C1b C    31.5228  -18.5057
            15  C6a C    32.7210  -17.8140
            16  O5a O    29.1265  -19.8892
            17  O6a O    33.9191  -18.5057
            18  O6a O    32.7210  -16.4305
            19  C8x C    30.3246  -16.4305
            20  C8y C    29.1264  -15.7387
            21  C8x C    31.5228  -15.7387
            22  C8x C    31.5228  -14.3552
            23  C8x C    30.3245  -13.6635
            24  C8x C    29.1264  -14.3552
            25  C8y C    21.9574  -15.7502
            26  C8x C    21.9574  -14.3502
            27  C8x C    20.7450  -13.6502
            28  C8x C    19.5325  -14.3502
            29  C8y C    19.5326  -15.7503
            30  C8x C    20.7450  -16.4502
            31  O1a O    18.3183  -16.4513
            32  C1a C    23.1358  -15.0305
            33  O0  O    38.7802  -16.8251
BOND        33
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     2   7 1
            7     3   8 1 #Down
            8     5   9 1
            9     9  10 1
            10   10  12 1
            11   12  13 1
            12   13  14 1
            13   14  15 1
            14   10  11 1 #Down
            15   12  16 2
            16   15  17 1
            17   15  18 2
            18   20  11 1
            19   20  19 2
            20   19  21 1
            21   21  22 2
            22   22  23 1
            23   23  24 2
            24   20  24 1
            25    2  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   28  29 1
            30   29  30 2
            31   25  30 1
            32   29  31 1
            33    2  32 1 #Up
BRACKET     1    36.5400  -17.6400   36.5400  -16.1000
            1    39.6200  -16.1000   39.6200  -17.6400
            1  2
 ORIGINAL  1    1
 REPEAT    1   33

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