KEGG   DRUG: ImigluceraseHelp
Entry
D03020                      Drug                                   

Name
Imiglucerase (USAN/INN);
Imiglucerase (genetical recombination) (JAN);
Cerezyme (TN)
Product
Formula
C2532H3843N671O711S16
Exact mass
55537.0717
Mol weight
55571.7149
Sequence
ARPCIPKSFG YSSVVCVCNA TYCDSFDPPT FPALGTFSRY ESTRSGRRME LSMGPIQANH
TGTGLLLTLQ PEQKFQKVKG FGGAMTDAAA LNILALSPPA QNLLLKSYFS EEGIGYNIIR
VPMASCDFSI RTYTYADTPD DFQLHNFSLP EEDTKLKIPL IHRALQLAQR PVSLLASPWT
SPTWLKTNGA VNGKGSLKGQ PGDIYHQTWA RYFVKFLDAY AEHKLQFWAV TAENEPSAGL
LSGYPFQCLG FTPEHQRDFI ARDLGPTLAN STHHNVRLLM LDDQRLLLPH WAKVVLTDPE
AAKYVHGIAV HWYLDFLAPA KATLGETHRL FPNTMLFASE ACVGSKFWEQ SVRLGSWDRG
MQYSHSIITN LLYHVVGWTD WNLALNPEGG PNWVRNFVDS PIIVDITKDT FYKQPMFYHL
GHFSKFIPEG SQRVGLVASQ KNDLDAVALM HPDGSAVVVV LNRSSKDVPL TIKDPAVGFL
ETISPGYSIH TYLWHRQ
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB02
Product: D03020<JP/US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (glucocerebrosidase)
  Disease
Gaucher disease [DS:H00126]
Comment
Enzyme replacement therapy product
Target
GBA* [HSA_VAR:2629v1] [HSA:2629] [KO:K01201]
  Network
N10017  Replacement of deficient GBA
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB02 Imiglucerase
      D03020  Imiglucerase (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic or Enzyme Disorder: Replacement, Modifiers, Treatment
  Short Bowel Syndrome Agents
   Imiglucerase
    D03020  Imiglucerase (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D03020  Imiglucerase (USAN/INN); Imiglucerase (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Glycosidases
    GBA* [HSA_VAR:2629v1]
     D03020  Imiglucerase (USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03020
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D03020
BRITE hierarchy
Other DBs
CAS: 154248-97-2
PubChem: 47205823
DrugBank: DB00053
LinkDB All DBs

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