| Entry |
|
|---|
| Name |
Bromfenac sodium (USAN);
Bromfenac sodium hydrate (JP18);
Bromfenac sodium sesquihydrate;
Bromday (TN);
Prolensa (TN);
Xibrom (TN);
Yellox (TN) |
|---|
| Product |
|
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| Generic |
BROMFENAC (ARMAS PHARMACEUTICALS), BROMFENAC (Alembic Pharmaceuticals Limited), BROMFENAC (Aurobindo Pharma Limited), BROMFENAC (Fosun Pharma USA), BROMFENAC (Gland Pharma Limited), BROMFENAC (Lupin Pharmaceuticals), BROMFENAC (Lupin Pharmaceuticals), BROMFENAC (Sun Pharmaceutical Industries), BROMFENAC OPHTHALMIC SOLUTION (Bausch & Lomb Americas), BROMFENAC OPHTHALMIC SOLUTION 0.09% (Alembic Pharmaceuticals), BROMFENAC SODIUM (Lupin Pharmaceuticals) |
|---|
| Formula |
(C15H11BrNO3)2. 2Na. 3H2O
|
|---|
| Exact mass |
763.9957
|
|---|
| Mol weight |
766.3389
|
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| Structure |
|
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
|
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| Remark |
| Therapeutic category: | 1319 |
| Product (DG01128): | D03163<JP/US> |
|
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| Efficacy |
Analgesic, Anti-inflammatory (ophthalmic), COX inhibitor |
|---|
| Target |
|
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| Pathway |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC11 Bromfenac
D03163 Bromfenac sodium (USAN) <JP/US>
USP drug classification [BR:br08302]
Ophthalmic Agents
Ophthalmic Anti-inflammatories
Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
Bromfenac
D03163 Bromfenac sodium (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D03163 Bromfenac sodium (USAN); Bromfenac sodium hydrate (JP18)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG01128 Bromfenac
D03163 Bromfenac sodium
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D03163 Bromfenac sodium
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D03163 Bromfenac sodium (USAN) <JP/US>
PTGS2 (COX2)
D03163 Bromfenac sodium (USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D03163 Bromfenac sodium hydrate
D03163 Bromfenac sodium ophthalmic solution
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D03163
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D03163
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG01128 Bromfenac
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 45
1 O0 O 27.9740 -15.4853
2 C8y C 15.7500 -14.3500
3 C8x C 15.7500 -15.7500
4 C8x C 16.9624 -16.4500
5 C8x C 18.1749 -15.7500
6 C8y C 18.1749 -14.3500
7 C8y C 16.9624 -13.6500
8 N1a N 16.9624 -12.2502
9 C1b C 19.4060 -13.6390
10 C6a C 20.6112 -14.3347
11 O6a O 21.7935 -13.6519 #-
12 O6a O 20.6116 -15.7496
13 C5a C 14.5376 -13.6500
14 C8y C 13.3421 -14.3404
15 O5a O 14.5375 -12.2502
16 C8x C 12.1547 -13.6549
17 C8x C 10.9423 -14.3550
18 C8y C 10.9424 -15.7550
19 C8x C 12.1297 -16.4404
20 C8x C 13.3421 -15.7404
21 X Br 9.7155 -16.4636
22 Z Na 26.8800 -11.9700 #+
23 O0 O 27.9740 -15.4853
24 O0 O 27.9740 -15.4853
25 C8y C 15.7500 -14.3500
26 C8x C 15.7500 -15.7500
27 C8x C 16.9624 -16.4500
28 C8x C 18.1749 -15.7500
29 C8y C 18.1749 -14.3500
30 C8y C 16.9624 -13.6500
31 N1a N 16.9624 -12.2502
32 C1b C 19.4060 -13.6390
33 C6a C 20.6112 -14.3347
34 O6a O 21.7935 -13.6519 #-
35 O6a O 20.6116 -15.7496
36 C5a C 14.5376 -13.6500
37 C8y C 13.3421 -14.3404
38 C8x C 12.1547 -13.6549
39 C8x C 10.9423 -14.3550
40 C8y C 10.9424 -15.7550
41 C8x C 12.1297 -16.4404
42 C8x C 13.3421 -15.7404
43 X Br 9.7155 -16.4636
44 O5a O 14.5375 -12.2502
45 Z Na 26.8800 -11.9700 #+
BOND 42
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 7 8 1
8 6 9 1
9 9 10 1
10 10 11 1
11 10 12 2
12 2 13 1
13 13 14 1
14 13 15 2
15 14 16 2
16 16 17 1
17 17 18 2
18 18 19 1
19 19 20 2
20 14 20 1
21 18 21 1
22 25 26 2
23 26 27 1
24 27 28 2
25 28 29 1
26 29 30 2
27 25 30 1
28 30 31 1
29 29 32 1
30 32 33 1
31 33 34 1
32 33 35 2
33 25 36 1
34 36 37 1
35 36 44 2
36 37 38 2
37 38 39 1
38 39 40 2
39 40 41 1
40 41 42 2
41 37 42 1
42 40 43 1
BRACKET 1 26.1100 -16.5200 26.1100 -14.4900
1 28.4900 -14.4900 28.4900 -16.5200
1 3
ORIGINAL 1 1
REPEAT 1 23 24
2 9.3800 -17.6400 9.3800 -10.7100
2 22.4700 -10.7100 22.4700 -17.6400
2 2
ORIGINAL 2 2 3 4 5 6 7 8 9 10 11 12 13 14 16 17 18
2 19 20 21 15
REPEAT 2 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40
2 41 42 43 44
3 25.8300 -12.8800 25.8300 -10.9200
3 28.4900 -10.9200 28.4900 -12.8800
3 2
ORIGINAL 3 22
REPEAT 3 45
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