KEGG   DRUG: BelataceptHelp
Entry
D03222                      Drug                                   

Name
Belatacept (USAN/INN);
Nulojix (TN)
Product
Formula
C3508H5440N922O1096S32
Exact mass
79042.9351
Mol weight
79092.329
Sequence
MHVAQPAVVL ASSRGIASFV CEYASPGKYT EVRVTVLRQA DSQVTEVCAA TYMMGNELTF
LDDSICTGTS SGNQVNLTIQ GLRAMDTGLY ICKVELMYPP PYYEGIGNGT QIYVIDPEPC
PDSDQEPKSS DKTHTSPPSP APELLGGSSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED
PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA
PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN
YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Disulfide bridge: 21-92; 48-66; 171-231; 277-335, Dimer: 120)
  Type
Peptide
Remark
ATC code: L04AA28
Product: D03222<US>
Efficacy
Antirheumatic, Immunosuppressant
  Disease
Organ rejection, kidney transplant [DS:H00083]
Comment
Fusion protein (extracellular domain of CTLA4 fused to Fc of a human IgG1)
Prevention of allograft rejection in recipients of solid organ transplants, Prevention of graft-vs.-host disease following bone marrow transplantation, Treatment of autoimmune diseases and conditions such as rheumatoid arthritis
Target
CD80 [HSA:941] [KO:K05412]
CD86 [HSA:942] [KO:K05413]
  Pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04672  Intestinal immune network for IgA production
hsa05330  Allograft rejection
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA28 Belatacept
      D03222  Belatacept (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD80
     D03222  Belatacept (USAN/INN) <US>
    CD86
     D03222  Belatacept (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03222
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03222
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03222
BRITE hierarchy
Other DBs
CAS: 706808-37-9
PubChem: 17397375
LinkDB All DBs

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