KEGG   DRUG: Agalsidase betaHelp
Entry
D03228                      Drug                                   

Name
Agalsidase beta (INN);
Agalsidase beta (genetical recombination) (JAN);
Agalsidase beta (genetical recombination) [Agalsidase beta biosimilar 1] (JAN);
Fabrazyme (TN)
Product
Sequence
LDNGLARTPT MGWLHWERFM CNLDCQEEPD SCISEKLFME MAELMVSEGW KDAGYEYLCI
DDCWMAPQRD SEGRLQADPQ RFPHGIRQLA NYVHSKGLKL GIYADVGNKT CAGFPGSFGY
YDIDAQTFAD WGVDLLKFDG CYCDSLENLA DGYKHMSLAL NRTGRSIVYS CEWPLYMWPF
QKPNYTEIRQ YCNHWRNFAD IDDSWKSIKS ILDWTSFNQE RIVDVAGPGG WNDPDMLVIG
NFGLSWNQQV TQMALWAIMA APLFMSNDLR HISPQAKALL QDKDVIAINQ DPLGKQGYQL
RQGDNFEVWE RPLSGLAWAV AMINRQEIGG PRSYTIAVAS LGKGVACNPA CFITQLLPVK
RKLGFYEWTS RLRSHINPTG TVLLQLENTM QMSLKDLL
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB04
Product: D03228<JP/US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (alpha-galactosidase)
  Disease
Fabry disease [DS:H00125]
Comment
Enzyme replacement therapy product
Target
GLA* [HSA_VAR:2717v1] [HSA:2717] [KO:K01189]
  Network
N10015  Replacement of deficient GLA
  Pathway
hsa00600  Sphingolipid metabolism
hsa04142  Lysosome
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB04 Agalsidase beta
      D03228  Agalsidase beta (INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic or Enzyme Disorder: Replacement, Modifiers, Treatment
  Short Bowel Syndrome Agents
   Agalsidase Beta
    D03228  Agalsidase beta (INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D03228  Agalsidase beta (INN); Agalsidase beta (genetical recombination) (JAN); Agalsidase beta (genetical recombination) [Agalsidase beta biosimilar 1] (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Glycosidases
    GLA* [HSA_VAR:2717v1]
     D03228  Agalsidase beta (INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03228
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03228
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D03228
BRITE hierarchy
Other DBs
CAS: 104138-64-9
PubChem: 17397381
DrugBank: DB00103
LinkDB All DBs

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