KEGG   DRUG: Epoetin alfa
Entry
D03231                      Drug                                   
Name
Epoetin alfa (USAN/INN);
Epoetin kappa (INN);
Epoetin alfa (genetical recombination) (JP18);
Epoetin kappa (genetical recombination) [Epoetin alfa biosimilar 1] (JAN);
Epoetin alfa-epbx;
Epogen (TN);
Epoetin alfa BS (TN)
Product
Formula
C809H1301N229O240S5
Exact mass
18224.5242
Mol weight
18235.7015
Sequence
APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA
VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS
PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGD
(Disulfide bridge: 7-161, 29-33)
  Type
Peptide
Remark
Therapeutic category: 3999
ATC code: B03XA01
Chemical structure group: DG00177
Product (DG00177): D03231<JP/US> D03232<JP>
Efficacy
Anti-anemic, Hematinic, Erythropoietin receptor agonist
  Disease
Anemia due to chronic kidney disease [DS:H01642]
Target
EPOR [HSA:2057] [KO:K05079]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B03 ANTIANEMIC PREPARATIONS
   B03X OTHER ANTIANEMIC PREPARATIONS
    B03XA Other antianemic preparations
     B03XA01 Erythropoietin
      D03231  Epoetin alfa (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Blood Products and Modifiers, Other
   Erythropoietins
    Epoetin Alfa
     D03231  Epoetin alfa (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03231  Epoetin alfa (USAN/INN); Epoetin kappa (INN); Epoetin alfa (genetical recombination) (JP18); Epoetin kappa (genetical recombination) [Epoetin alfa biosimilar 1] (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    EPOR
     D03231  Epoetin alfa (USAN/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D03231  Epoetin alfa (genetical recombination)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03231
Other DBs
CAS: 113427-24-0
PubChem: 17397384
LinkDB

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