KEGG   DRUG: Darbepoetin alfa
Entry
D03651                      Drug                                   
Name
Darbepoetin alfa (USAN/INN);
Darbepoetin alfa (genetical recombination) (JAN);
Darbepoetin alfa (genetical recombination) [Darbepoetin alfa biosimilar 1] (JAN);
Darbepoetin alfa (genetical recombination) [Darbepoetin alfa biosimilar 2] (JAN);
Darbepoetin alfa (genetical recombination) [Darbepoetin alfa biosimilar 3] (JAN);
Aranesp (TN)
Product
ARANESP (Amgen)
Formula
C800H1300N228O24S5
Exact mass
14646.6117
Mol weight
14656.73
Sequence
PPRLICDSR VLERYLLEAK EAENITTGCN ETCSLNENIT VPDTKVNFYA WKRMEVGQQA
VEVWQGLALL SEAVLRGQAL LVNSSQVNET LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS
PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR
  Type
Peptide
Remark
Therapeutic category: 3999
ATC code: B03XA02
Product: D03651<JP/US>
Efficacy
Anti-anemic, Erythropoietin receptor agonist
  Disease
Anemia due to chronic kidney disease [DS:H01642]
Target
EPOR [HSA:2057] [KO:K05079]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B03 ANTIANEMIC PREPARATIONS
   B03X OTHER ANTIANEMIC PREPARATIONS
    B03XA Other antianemic preparations
     B03XA02 Darbepoetin alfa
      D03651  Darbepoetin alfa (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Erythropoiesis Promoters
   Erythropoiesis-Stimulating Agents
    Darbepoetin Alfa
     D03651  Darbepoetin alfa (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03651  Darbepoetin alfa (USAN/INN); Darbepoetin alfa (genetical recombination) (JAN); Darbepoetin alfa (genetical recombination) [Darbepoetin alfa biosimilar 1] (JAN); Darbepoetin alfa (genetical recombination) [Darbepoetin alfa biosimilar 2] (JAN); Darbepoetin alfa (genetical recombination) [Darbepoetin alfa biosimilar 3] (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    EPOR
     D03651  Darbepoetin alfa (USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03651
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03651
Other DBs
CAS: 209810-58-2
PubChem: 17397749
LinkDB

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