KEGG   DRUG: DesonideHelp
Entry
D03696                      Drug                                   

Name
Desonide (USAN/INN);
Desowen (TN);
Verdeso (TN)
Product
  Generic
Formula
C24H32O6
Exact mass
416.2199
Mol weight
416.5073
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: D07AB08 S01BA11
Product: D03696<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB08 Desonide
      D03696  Desonide (USAN/INN) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA11 Desonide
      D03696  Desonide (USAN/INN) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Desonide
   D03696  Desonide (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D03696  Desonide (USAN/INN) <US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D03696
BRITE hierarchy
Other DBs
CAS: 638-94-8
PubChem: 17397789
ChEBI: 204734
ChEMBL: CHEMBL1201109 CHEMBL1871261
DrugBank: DB01260
LigandBox: D03696
NIKKAJI: J6.927B
LinkDB All DBs
KCF data Show

ATOM        30
            1   C2x C    29.0870  -20.6780
            2   C5x C    29.0870  -22.0509
            3   C2x C    30.2760  -22.7374
            4   C2y C    31.4650  -22.0509
            5   C1z C    31.4650  -20.6780
            6   C2x C    30.2760  -19.9916
            7   C1x C    32.6539  -22.7374
            8   C1x C    33.8429  -22.0509
            9   C1y C    33.8429  -20.6780
            10  C1y C    32.6539  -19.9916
            11  C1y C    35.0319  -19.9916
            12  C1z C    35.0319  -18.6187
            13  C1x C    33.8429  -17.9322
            14  C1y C    32.6539  -18.6187
            15  C1x C    37.4098  -19.9916
            16  C1y C    37.4098  -18.6187
            17  C1z C    36.2208  -17.9322
            18  O2x O    38.7827  -18.6187
            19  C1z C    38.7827  -17.2458
            20  C1a C    38.7827  -15.8728
            21  O2x O    37.4098  -17.2458
            22  C1a C    40.1556  -17.2458
            23  C5a C    36.2208  -16.2793
            24  O5a O    37.4138  -15.5906
            25  C1b C    35.0358  -15.5951
            26  O5x O    27.8981  -22.7374
            27  C1a C    31.4650  -19.3051
            28  O1a O    31.4670  -17.9334
            29  C1a C    35.0319  -17.2458
            30  O1a O    33.8431  -16.2843
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   16  18 1 #Down
            22   18  19 1
            23   19  20 1
            24   17  21 1 #Down
            25   21  19 1
            26   19  22 1
            27   17  23 1 #Up
            28   23  24 2
            29   23  25 1
            30    2  26 2
            31    5  27 1 #Up
            32   14  28 1 #Up
            33   12  29 1 #Up
            34   25  30 1

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