KEGG   DRUG: TipifarnibHelp
Entry
D03720                      Drug                                   

Name
Tipifarnib (USAN/INN)
Formula
C27H22Cl2N4O
Exact mass
488.1171
Mol weight
489.3958
Structure
Mol fileKCF fileDB search
Efficacy
Antineoplastic
Comment
Treatment of advanced pancreatic cancer, colorectal cancer, and nonsmall cell lung cancer
Target
FNT [HSA:2339 2342] [KO:K05955 K05954]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Alkyl/Aryl transferases
    FNT
     D03720  Tipifarnib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 192185-72-1
PubChem: 17397811
ChEBI: 141969
ChEMBL: CHEMBL289228
PDB-CCD: JAN[PDBj]
LigandBox: D03720
NIKKAJI: J2.227.995E
LinkDB All DBs
KCF data Show

ATOM        34
            1   C8x C    34.0302  -16.5229
            2   C8y C    34.0302  -17.9291
            3   C8x C    35.2254  -18.6322
            4   C8y C    36.4910  -17.9291
            5   C8y C    36.4910  -16.5229
            6   C8x C    35.2254  -15.8198
            7   C8y C    37.6862  -18.6322
            8   C8x C    38.8815  -17.9291
            9   C8y C    38.8815  -16.5229
            10  N4y N    37.6862  -15.8198
            11  C1d C    32.8349  -18.6322
            12  C8y C    37.6862  -20.0384
            13  C8x C    36.4910  -20.7415
            14  C8x C    36.4910  -22.1476
            15  C8x C    37.6862  -22.8507
            16  C8y C    38.8815  -22.1476
            17  C8x C    38.8815  -20.7415
            18  X   Cl   40.0767  -22.8507
            19  O5x O    40.0767  -15.8198
            20  C1a C    37.6862  -14.4137
            21  C8y C    31.6079  -17.9371
            22  C8x C    31.6659  -16.5207
            23  C8x C    30.3776  -15.8309
            24  C8y C    29.1711  -16.5412
            25  C8x C    29.1831  -17.9575
            26  C8x C    30.4014  -18.6473
            27  X   Cl   27.9583  -15.8544
            28  C8y C    32.8349  -20.0322
            29  N4y N    31.7049  -20.8532
            30  C8x C    32.1365  -22.1816
            31  N5x N    33.5333  -22.1816
            32  C8x C    33.9649  -20.8532
            33  C1a C    30.3801  -20.4227
            34  N1a N    31.6225  -19.3322
BOND        38
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    2  11 1
            13    7  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20   16  18 1
            21    9  19 2
            22   10  20 1
            23   11  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   24  27 1
            31   11  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 2
            35   31  32 1
            36   28  32 2
            37   29  33 1
            38   11  34 1 #Down

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