KEGG   DRUG: Lidorestat
Entry
D03803                      Drug                                   
Name
Lidorestat (USAN)
Formula
C18H11F3N2O2S. H2O
Exact mass
394.0599
Mol weight
394.3676
Structure
Class
Antidiabetic agent
 DG01882  Aldose reductase inhibitor
Efficacy
Hypoglycemic, Aldose reductase inhibitor
Comment
Treatment of diabetic complications, including neuropathy, retinopathy cataracts, nephropathy
Target
AKR1B1 [HSA:231] [KO:K00011]
  Pathway
hsa00051  Fructose and mannose metabolism
hsa00052  Galactose metabolism
Interaction
Brite
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01882  Aldose reductase inhibitor
   D03803  Lidorestat
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    AKR1B1
     D03803  Lidorestat (USAN)
Other DBs
PubChem: 17397891
LigandBox: D03803
LinkDB
KCF data

ATOM        27
            1   C8y C    35.1563  -20.9396
            2   N5x N    35.2963  -19.5389
            3   S2x S    36.4169  -21.5698
            4   C8y C    36.6270  -19.2588
            5   C8y C    37.3273  -20.5194
            6   C8y C    37.3973  -18.0682
            7   C8y C    38.7280  -20.5194
            8   C8y C    38.7980  -18.0682
            9   C8x C    39.4283  -19.2588
            10  X   F    36.6970  -16.8076
            11  X   F    39.4983  -16.8776
            12  X   F    39.4283  -21.7099
            13  C1b C    33.9657  -21.6399
            14  C8y C    32.7051  -20.9396
            15  C8y C    31.3045  -20.9396
            16  C8x C    33.1253  -19.6089
            17  N4y N    32.0048  -18.7685
            18  C8y C    30.8843  -19.6089
            19  C1b C    32.0048  -17.3679
            20  C6a C    33.1954  -16.6675
            21  O6a O    34.3859  -17.3679
            22  O6a O    33.1954  -15.2669
            23  C8x C    29.5167  -19.3064
            24  C8x C    28.5709  -20.3395
            25  C8x C    28.9911  -21.6701
            26  C8x C    30.3586  -21.9726
            27  O0  O    44.2400  -19.6700
BOND        29
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     5   7 1
            7     6   8 2
            8     7   9 2
            9     4   5 2
            10    8   9 1
            11    6  10 1
            12    8  11 1
            13    7  12 1
            14    1  13 1
            15   13  14 1
            16   15  14 1
            17   14  16 2
            18   16  17 1
            19   17  18 1
            20   15  18 1
            21   17  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 2
            25   18  23 2
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   15  26 2

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