Entry |
|
Name |
Lidorestat (USAN) |
Formula |
C18H11F3N2O2S. H2O
|
Exact mass |
394.0599
|
Mol weight |
394.3676
|
Structure |
|
Class |
Antidiabetic agent
DG01882 Aldose reductase inhibitor
|
Efficacy |
Hypoglycemic, Aldose reductase inhibitor |
Comment |
Treatment of diabetic complications, including neuropathy, retinopathy cataracts, nephropathy
|
Target |
|
Pathway |
hsa00051 | Fructose and mannose metabolism |
|
Interaction |
|
Brite |
Drug groups [BR:br08330]
Antidiabetic agent
DG01882 Aldose reductase inhibitor
D03803 Lidorestat
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
AKR1B1
D03803 Lidorestat (USAN)
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 27
1 C8y C 35.1563 -20.9396
2 N5x N 35.2963 -19.5389
3 S2x S 36.4169 -21.5698
4 C8y C 36.6270 -19.2588
5 C8y C 37.3273 -20.5194
6 C8y C 37.3973 -18.0682
7 C8y C 38.7280 -20.5194
8 C8y C 38.7980 -18.0682
9 C8x C 39.4283 -19.2588
10 X F 36.6970 -16.8076
11 X F 39.4983 -16.8776
12 X F 39.4283 -21.7099
13 C1b C 33.9657 -21.6399
14 C8y C 32.7051 -20.9396
15 C8y C 31.3045 -20.9396
16 C8x C 33.1253 -19.6089
17 N4y N 32.0048 -18.7685
18 C8y C 30.8843 -19.6089
19 C1b C 32.0048 -17.3679
20 C6a C 33.1954 -16.6675
21 O6a O 34.3859 -17.3679
22 O6a O 33.1954 -15.2669
23 C8x C 29.5167 -19.3064
24 C8x C 28.5709 -20.3395
25 C8x C 28.9911 -21.6701
26 C8x C 30.3586 -21.9726
27 O0 O 44.2400 -19.6700
BOND 29
1 1 2 2
2 1 3 1
3 2 4 1
4 3 5 1
5 4 6 1
6 5 7 1
7 6 8 2
8 7 9 2
9 4 5 2
10 8 9 1
11 6 10 1
12 8 11 1
13 7 12 1
14 1 13 1
15 13 14 1
16 15 14 1
17 14 16 2
18 16 17 1
19 17 18 1
20 15 18 1
21 17 19 1
22 19 20 1
23 20 21 1
24 20 22 2
25 18 23 2
26 23 24 1
27 24 25 2
28 25 26 1
29 15 26 2
|