KEGG   DRUG: Farglitazar
Entry
D04132                      Drug                                   
Name
Farglitazar (USAN/INN)
Formula
C34H30N2O5
Exact mass
546.2155
Mol weight
546.6124
Structure
Simcomp
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01795  PPAR gamma agonist
   DG01732  Non-thiazolidinedione type PPAR agonist
Efficacy
Antidiabetic, Peroxisome proliferator-activated receptor (PPAR) gamma agonist
Comment
Treatment of type II diabetes (insulin action enhancer)
Target
NR1C3 (PPARG) [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway
hsa04152  AMPK signaling pathway
Interaction
Brite
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01685  Insulin sensitizer
   DG01795  PPAR gamma agonist
    DG01732  Non-thiazolidinedione type PPAR agonist
     D04132  Farglitazar
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C3 (PPARG)
     D04132  Farglitazar (USAN/INN)
Other DBs
CAS: 196808-45-4
PubChem: 47206079
PDB-CCD: 570[PDBj]
LigandBox: D04132
LinkDB
KCF data

ATOM        41
            1   C8x C    17.2200  -20.8600
            2   C8y C    17.2200  -22.2600
            3   C8x C    18.4324  -22.9600
            4   C8x C    19.6449  -22.2600
            5   C8y C    19.6449  -20.8600
            6   C8x C    18.4324  -20.1600
            7   O2a O    16.0076  -22.9600
            8   C1b C    20.8760  -20.1490
            9   C1b C    14.8121  -22.2696
            10  C1b C    13.6247  -22.9551
            11  C8y C    12.4335  -22.2671
            12  C8y C    12.4807  -20.8602
            13  O2x O    11.1610  -20.3809
            14  C8y C    10.2974  -21.4880
            15  N5x N    11.0834  -22.6514
            16  C1a C    13.6263  -20.0855
            17  C8y C     8.8909  -21.5099
            18  C8x C     8.1630  -20.2936
            19  C8x C     6.7631  -20.3155
            20  C8x C     6.0822  -21.5388
            21  C8x C     6.8102  -22.7552
            22  C8x C     8.2100  -22.7332
            23  C1c C    22.0812  -20.8447
            24  C6a C    23.2635  -20.1619
            25  N1b N    22.0816  -22.2596
            26  O6a O    24.4575  -20.8512
            27  O6a O    23.2635  -18.7602
            28  C8y C    23.2705  -22.9459
            29  C8y C    23.2709  -24.3597
            30  C8x C    24.4836  -25.0593
            31  C8x C    25.6958  -24.3589
            32  C8x C    25.6953  -22.9451
            33  C8x C    24.4827  -22.2455
            34  C5a C    22.0356  -25.0737
            35  O5a O    20.8278  -24.3772
            36  C8y C    22.0364  -26.4599
            37  C8x C    20.8346  -27.1548
            38  C8x C    20.8355  -28.5548
            39  C8x C    22.0484  -29.2541
            40  C8x C    23.2502  -28.5592
            41  C8x C    23.2493  -27.1592
BOND        45
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     5   8 1
            9     7   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 1
            15   14  15 2
            16   11  15 1
            17   12  16 1
            18   14  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25    8  23 1
            26   23  24 1 #Up
            27   23  25 1
            28   24  26 1
            29   24  27 2
            30   25  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   31  32 1
            35   32  33 2
            36   28  33 1
            37   29  34 1
            38   34  35 2
            39   34  36 1
            40   36  37 2
            41   37  38 1
            42   38  39 2
            43   39  40 1
            44   40  41 2
            45   36  41 1

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