KEGG   DRUG: FlumethasoneHelp
Entry
D04208                      Drug                                   

Name
Flumethasone (USAN);
Flumetasone (INN)
Formula
C22H28F2O5
Exact mass
410.1905
Mol weight
410.4515
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C14479
ATC code: D07AB03 D07XB01
Chemical structure group: DG00412
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB03 Flumetasone
      D04208  Flumethasone (USAN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB01 Flumetasone
      D04208  Flumethasone (USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D04208  Flumethasone (USAN)
BRITE hierarchy
Other DBs
CAS: 2135-17-3
PubChem: 47206154
ChEBI: 34764
ChEMBL: CHEMBL1201392
LigandBox: D04208
NIKKAJI: J7.332F
LinkDB All DBs
KCF data Show

ATOM        29
            1   C2x C    19.6700  -29.2600
            2   C5x C    19.6700  -30.6600
            3   C2x C    20.8600  -31.2900
            4   C2y C    22.0500  -30.6600
            5   C1z C    22.0500  -29.2600
            6   C2x C    20.8600  -28.6300
            7   C1y C    23.1700  -31.2900
            8   C1x C    24.3600  -30.6600
            9   C1y C    24.3600  -29.2600
            10  C1z C    23.1700  -28.6300
            11  C1y C    25.5500  -28.6300
            12  C1z C    25.5500  -27.2300
            13  C1x C    24.3600  -26.6000
            14  C1y C    23.1700  -27.2300
            15  C1x C    27.9300  -28.6300
            16  C1y C    27.9300  -27.2300
            17  C1z C    26.7400  -26.6000
            18  C1a C    22.0500  -27.9300
            19  O1a O    22.0500  -26.6000
            20  C1a C    25.5500  -25.9000
            21  C1a C    29.0500  -26.6000
            22  C5a C    26.7400  -24.8500
            23  X   F    23.1700  -29.9600
            24  O1a O    27.9300  -25.6900
            25  O5x O    18.4800  -31.2900
            26  O5a O    27.9300  -24.2200
            27  C1b C    25.5500  -24.2200
            28  O1a O    24.4300  -24.8500
            29  X   F    23.1522  -32.6899
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32    7  29 1 #Down

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