KEGG   DRUG: Icatibant acetate
Entry
D04492                      Drug                                   
Name
Icatibant acetate (JAN/USAN);
Firazyr (TN)
Product
FIRAZYR (Takeda Pharmaceuticals America)
  Generic
ICATIBANT (Apotex Corp.), ICATIBANT (Bryant Ranch Prepack), ICATIBANT (Cipla USA), ICATIBANT (Eugia US LLC), ICATIBANT (Fresenius Kabi USA), ICATIBANT (Hikma Pharmaceuticals USA), ICATIBANT (Slayback Pharma LLC), ICATIBANT (Teva Pharmaceuticals USA), SAJAZIR (Cycle Pharmaceuticals Ltd-Uk)
Formula
C59H89N19O13S. (C2H4O2)x
Structure
Remark
Therapeutic category: 4490
ATC code: B06AC02
Product: D04492<JP/US>
Efficacy
Antiangioedema, Bradykinin receptor antagonist
  Disease
Hereditary angioedema [DS:H01006]
Target
BDKRB2 [HSA:624] [KO:K03916]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04961  Endocrine and other factor-regulated calcium reabsorption
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B06 OTHER HEMATOLOGICAL AGENTS
   B06A OTHER HEMATOLOGICAL AGENTS
    B06AC Drugs used in hereditary angioedema
     B06AC02 Icatibant
      D04492  Icatibant acetate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Angioedema Agents
   Bradykinin B2 receptor antagonists
    Icatibant
     D04492  Icatibant acetate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D04492  Icatibant acetate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Bradykinin
    BDKRB2
     D04492  Icatibant acetate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04492
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04492
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04492
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04492
Other DBs
CAS: 138614-30-9
PubChem: 47206340
ChEBI: 68564
LigandBox: D04492
LinkDB
KCF data

ATOM        96
            1   C1a C    51.4861  -17.2259
            2   C6a C    52.6784  -16.5245
            3   O6a O    53.9409  -17.2259
            4   O6a O    52.6784  -15.1218
            5   N1y N    32.5493  -15.1919
            6   C5a C    33.8118  -14.4906
            7   C1c C    35.0041  -15.1919
            8   N1b N    36.1964  -14.4906
            9   C5a C    37.4589  -15.1919
            10  C1c C    38.6512  -14.4906
            11  C1b C    39.8435  -15.1919
            12  C1b C    41.1060  -14.4906
            13  C1b C    42.2983  -15.1919
            14  N1b N    43.4906  -14.4906
            15  C2c C    44.7530  -15.1919
            16  N1a N    45.9454  -14.4906
            17  N2a N    44.7530  -16.5947
            18  N1a N    38.6512  -13.0879
            19  O5a O    37.4589  -16.5947
            20  C1b C    35.0041  -16.5947
            21  O5a O    33.8118  -13.0879
            22  C1y C    31.2869  -14.6308
            23  C1x C    30.3050  -15.6829
            24  C1x C    31.0064  -16.8752
            25  C1x C    32.4090  -16.5947
            26  C5a C    31.0064  -13.2281
            27  N1y N    29.6737  -12.8073
            28  O5a O    32.0584  -12.3164
            29  C1x C    29.2530  -11.4747
            30  C1y C    27.7801  -11.4747
            31  C1x C    27.3593  -12.8073
            32  C1y C    28.4814  -13.6490
            33  C5a C    28.4814  -15.0516
            34  O1a O    26.9385  -10.3525
            35  N1b N    27.2891  -15.7530
            36  C1b C    26.0968  -15.0516
            37  C5a C    24.9045  -15.7530
            38  N1b N    23.7122  -15.0516
            39  C1c C    22.5199  -15.7530
            40  O5a O    29.6737  -15.7530
            41  O5a O    24.9045  -17.1558
            42  C5a C    21.3276  -15.0516
            43  C1b C    22.5199  -17.1558
            44  C8y C    21.3276  -17.8571
            45  C8x C    20.0651  -17.2961
            46  C8x C    19.1533  -18.2779
            47  C8x C    19.7845  -19.4702
            48  S2x S    21.1873  -19.1898
            49  N1b N    20.1352  -15.7530
            50  O5a O    21.3276  -13.6490
            51  C1c C    18.9429  -15.0516
            52  C5a C    17.7506  -15.7530
            53  C1b C    18.9429  -13.6490
            54  N1y N    16.5583  -15.0516
            55  O5a O    17.7506  -17.1558
            56  O1a O    17.7506  -12.9476
            57  C1x C    16.5583  -13.6490
            58  C8y C    15.2958  -12.9476
            59  C8y C    14.1035  -13.6490
            60  C1x C    14.1035  -15.0516
            61  C1y C    15.2958  -15.7530
            62  C8x C    15.2958  -11.5448
            63  C8x C    14.1035  -10.8435
            64  C8x C    12.9112  -11.5448
            65  C8x C    12.9112  -12.9476
            66  C5a C    15.2958  -17.1558
            67  N1y N    14.1035  -17.8571
            68  O5a O    16.4882  -17.8571
            69  C1y C    12.7008  -17.8571
            70  C1x C    12.2800  -19.1898
            71  C1y C    13.4021  -20.0313
            72  C1y C    14.5243  -19.1898
            73  C5a C    11.4860  -17.1558
            74  N1b N    10.2711  -17.8571
            75  C1c C     9.0564  -17.1558
            76  C1b C     7.8416  -17.8571
            77  C1b C     6.6268  -17.1558
            78  C1b C     5.4120  -17.8571
            79  N1b N     4.1972  -17.1558
            80  C2c C     2.9824  -17.8571
            81  C1x C    13.5700  -21.4240
            82  C1x C    14.8598  -21.9750
            83  C1x C    15.9821  -21.1334
            84  C1x C    15.8143  -19.7407
            85  O5a O    11.4860  -15.7532
            86  C6a C     9.0564  -15.7530
            87  O6a O     7.8395  -15.0504
            88  O6a O    10.2691  -15.0528
            89  N1a N     1.7449  -17.1423
            90  N2a N     2.9822  -19.2595
            91  C1b C    33.7886  -17.2965
            92  C1b C    33.7886  -18.6962
            93  N1b N    32.5931  -19.3864
            94  C2c C    32.5931  -20.7862
            95  N1a N    31.3977  -21.4765
            96  N2a N    33.8196  -21.4945
BOND        101
            1     1   2 1
            2     2   3 1
            3     2   4 2
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     8   9 1
            8     9  10 1
            9    10  11 1
            10   11  12 1
            11   12  13 1
            12   13  14 1
            13   14  15 1
            14   15  16 1
            15   15  17 2
            16   10  18 1 #Down
            17    9  19 2
            18    7  20 1 #Up
            19    6  21 2
            20    5  22 1
            21   22  23 1
            22   23  24 1
            23   24  25 1
            24    5  25 1
            25   22  26 1 #Up
            26   26  27 1
            27   26  28 2
            28   27  29 1
            29   29  30 1
            30   30  31 1
            31   31  32 1
            32   27  32 1
            33   32  33 1 #Down
            34   30  34 1 #Up
            35   33  35 1
            36   35  36 1
            37   36  37 1
            38   37  38 1
            39   38  39 1
            40   33  40 2
            41   37  41 2
            42   39  42 1
            43   39  43 1 #Up
            44   43  44 1
            45   44  45 2
            46   45  46 1
            47   46  47 2
            48   47  48 1
            49   44  48 1
            50   42  49 1
            51   42  50 2
            52   49  51 1
            53   51  52 1
            54   51  53 1 #Down
            55   52  54 1
            56   52  55 2
            57   53  56 1
            58   54  57 1
            59   57  58 1
            60   58  59 1
            61   59  60 1
            62   60  61 1
            63   54  61 1
            64   58  62 2
            65   62  63 1
            66   63  64 2
            67   64  65 1
            68   59  65 2
            69   61  66 1 #Up
            70   66  67 1
            71   66  68 2
            72   67  69 1
            73   69  70 1
            74   70  71 1
            75   71  72 1
            76   67  72 1
            77   69  73 1
            78   73  74 1
            79   74  75 1
            80   75  76 1
            81   76  77 1
            82   77  78 1
            83   78  79 1
            84   79  80 1
            85   71  81 1
            86   81  82 1
            87   82  83 1
            88   83  84 1
            89   72  84 1
            90   73  85 2
            91   75  86 1 #Up
            92   86  87 1
            93   86  88 2
            94   80  89 1
            95   80  90 2
            96   20  91 1
            97   91  92 1
            98   92  93 1
            99   93  94 1
            100  94  95 1
            101  94  96 2
BRACKET     1    49.2100  -18.2700   49.2100  -14.0700
            1    55.4400  -14.0700   55.4400  -18.2700
            1  x
 ORIGINAL  1    1   2   3   4
 REPEAT    1

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