KEGG   DRUG: Lanreotide acetateHelp
Entry
D04666                      Drug                                   

Name
Lanreotide acetate (JAN/USAN);
Somatuline (TN)
Product
Formula
C54H69N11O10S2. (C2H4O2)x
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01588  Somatostatin receptor agonist
Remark
Therapeutic category: 2499
ATC code: H01CB03
Product: D04666<JP/US>
Efficacy
Antineoplastic, Antisecretory (hormone), Somatostatin receptor agonist
  Disease
Acromegaly [DS:H01483]
Comment
Somatostatin [DR:D07431] analog
Target
SSTR2 [HSA:6752] [KO:K04218]
SSTR5 [HSA:6755] [KO:K04221]
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01C HYPOTHALAMIC HORMONES
    H01CB Somatostatin and analogues
     H01CB03 Lanreotide
      D04666  Lanreotide acetate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Pituitary)
  Lanreotide
   D04666  Lanreotide acetate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D04666  Lanreotide acetate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Somatostatin
    SSTR2
     D04666  Lanreotide acetate (JAN/USAN) <JP/US>
    SSTR5
     D04666  Lanreotide acetate (JAN/USAN) <JP/US>
Antineoplastics [br08340.html]
 D04666
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04666
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04666
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04666
BRITE hierarchy
Other DBs
CAS: 127984-74-1
PubChem: 47206506
LinkDB All DBs
KCF data Show

ATOM        81
            1   C8y C    26.3200  -22.1900
            2   C8x C    25.6200  -23.3800
            3   C8x C    26.3200  -24.5700
            4   C8x C    27.7200  -24.5700
            5   C8x C    28.4900  -23.3800
            6   C8y C    27.7200  -22.1900
            7   N4x N    28.2100  -20.8600
            8   C8x C    27.0900  -19.9500
            9   C8y C    25.9000  -20.8600
            10  N1b N    18.6200  -13.7900
            11  C1y C    19.8800  -14.4900
            12  C5x C    19.8800  -15.8900
            13  O5x O    18.6200  -16.5900
            14  C5x C    28.4200  -16.5900
            15  C1y C    28.4200  -17.9900
            16  O5x O    27.1600  -15.8900
            17  N1x N    27.1600  -18.6900
            18  C5x C    25.9700  -17.9900
            19  C1y C    24.7100  -18.6900
            20  O5x O    25.9700  -16.5900
            21  N1x N    23.5200  -17.9900
            22  C5x C    22.3300  -18.6900
            23  C1y C    21.0700  -17.9900
            24  C1b C    19.8800  -18.6900
            25  N1x N    21.0700  -16.5900
            26  O5x O    22.3300  -20.0900
            27  C8y C    19.8800  -20.0900
            28  C5a C    17.4300  -14.4900
            29  C1c C    16.2400  -13.7900
            30  O5a O    17.4300  -15.8900
            31  N1a N    16.2400  -12.3900
            32  C1b C    15.0500  -14.4900
            33  C8x C    18.6200  -20.8600
            34  C8x C    18.6200  -22.1900
            35  C8y C    19.8800  -22.8900
            36  C8x C    21.0700  -22.1900
            37  C8x C    21.0700  -20.8600
            38  C1b C    24.7100  -20.0900
            39  C1b C    29.6100  -18.6900
            40  N1x N    29.6100  -15.8900
            41  C1b C    30.8700  -17.9900
            42  C1b C    32.0600  -18.6900
            43  C1b C    33.2500  -17.9900
            44  N1a N    34.4400  -18.6900
            45  C1y C    29.6100  -14.4900
            46  C5x C    28.4200  -13.7900
            47  C1c C    30.8000  -13.7900
            48  C1a C    32.0600  -14.4900
            49  C1a C    30.8000  -12.3900
            50  N1x N    27.1600  -14.4900
            51  O5x O    28.4200  -12.4600
            52  C1y C    25.9700  -13.8600
            53  C1x C    24.7100  -14.5600
            54  S3x S    23.5200  -13.8600
            55  C1x C    21.1400  -13.7900
            56  S3x S    22.3300  -14.4900
            57  C5a C    25.9700  -12.4600
            58  O5a O    27.0900  -11.7600
            59  N1b N    24.7100  -11.7600
            60  C1c C    24.7100  -10.2900
            61  C5a C    23.5200   -9.5900
            62  C1c C    25.9000   -9.5900
            63  O5a O    23.5200   -8.2600
            64  N1a N    22.3300  -10.2900
            65  C8y C    15.0500  -15.8900
            66  C8x C    13.8600  -16.5900
            67  C8x C    13.8600  -17.9900
            68  C8y C    15.0500  -18.6200
            69  C8y C    16.2400  -17.9900
            70  C8x C    16.2400  -16.5900
            71  O1a O    19.8800  -24.2900
            72  C1a C    25.9000   -8.1900
            73  C8x C    15.0686  -20.0191
            74  C8x C    16.1846  -20.7631
            75  C8x C    17.4446  -20.1331
            76  C8x C    17.4259  -18.7340
            77  O1a O    27.1153  -10.2851
            78  C6a C    34.0900  -22.8900
            79  C1a C    35.3024  -23.5900
            80  O6a O    32.8776  -23.5900
            81  O6a O    34.0900  -21.4900
BOND        85
            1     9   1 1
            2    47  48 1
            3     1   2 1
            4    47  49 1
            5     2   3 2
            6    46  50 1
            7    10  28 1
            8    46  51 2
            9     3   4 1
            10   50  52 1
            11   28  29 1
            12   52  53 1
            13    4   5 2
            14   53  54 1
            15   28  30 2
            16   11  55 1
            17    5   6 1
            18   55  56 1
            19   54  56 1
            20   29  31 1
            21   52  57 1
            22   29  32 1
            23   57  58 2
            24   11  12 1
            25   57  59 1
            26   27  33 2
            27   59  60 1
            28   33  34 1
            29   60  61 1
            30   34  35 2
            31   60  62 1
            32   35  36 1
            33   36  37 2
            34   61  63 2
            35   37  27 1
            36   61  64 1
            37   14  15 1
            38   19  38 1
            39   38   9 1
            40   12  13 2
            41   15  39 1
            42   14  16 2
            43   12  25 1
            44   15  17 1
            45   17  18 1
            46   18  19 1
            47   18  20 2
            48   19  21 1
            49   10  11 1
            50   21  22 1
            51   22  23 1
            52   23  24 1
            53   14  40 1
            54   32  65 1
            55   23  25 1
            56   39  41 1
            57   22  26 2
            58   41  42 1
            59   24  27 1
            60   65  66 2
            61   66  67 1
            62   67  68 2
            63   68  69 1
            64   69  70 2
            65   70  65 1
            66   42  43 1
            67    6   1 2
            68   43  44 1
            69    6   7 1
            70   40  45 1
            71    7   8 1
            72   45  46 1
            73    8   9 2
            74   45  47 1
            75   35  71 1
            76   62  72 1
            77   68  73 1
            78   73  74 2
            79   74  75 1
            80   75  76 2
            81   69  76 1
            82   62  77 1
            83   78  79 1
            84   78  80 1
            85   78  81 2
BRACKET     1    31.6400  -24.5700   31.6400  -20.5800
            1    37.0300  -20.5800   37.0300  -24.5700
            1  x
 ORIGINAL  1   78  79  80  81
 REPEAT    1

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