KEGG   DRUG: Lasofoxifene tartrate
Entry
D04672                      Drug                                   
Name
Lasofoxifene tartrate (JAN/USAN)
Formula
C28H31NO2. C4H6O6
Exact mass
563.2519
Mol weight
563.6381
Structure
Simcomp
Class
Hormonal agent
 DG01619  Estrogen receptor antagonist/modulator
  DG01621  Selective estrogen receptor modulator
Remark
ATC code: G03XC03
Efficacy
Osteoporosis agent, Selective estrogen receptor modulator (SERM)
Comment
Clomifene, tamoxifen derivative
Treatment and prevention of osteoporosis and breast cancer, reduction of cardiovascular risk
Target
NR3A (ESR) [HSA:2099 2100] [KO:K08550 K08551]
  Pathway
hsa04915  Estrogen signaling pathway
hsa04961  Endocrine and other factor-regulated calcium reabsorption
Structure map
map07047  Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03X OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
    G03XC Selective estrogen receptor modulators
     G03XC03 Lasofoxifene
      D04672  Lasofoxifene tartrate (JAN/USAN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01619  Estrogen receptor antagonist/modulator
   DG01621  Selective estrogen receptor modulator
    D04672  Lasofoxifene tartrate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   Estrogen receptor
    NR3A (ESR)
     D04672  Lasofoxifene tartrate (JAN/USAN)
Other DBs
CAS: 190791-29-8
PubChem: 47206511
LigandBox: D04672
NIKKAJI: J2.113.260H
LinkDB
KCF data

ATOM        41
            1   C1c C    26.5097  -16.9656
            2   C1c C    27.7011  -16.2648
            3   C6a C    25.2483  -16.2648
            4   O1a O    26.5097  -18.3673
            5   C6a C    28.8925  -16.9656
            6   O1a O    27.7011  -14.8631
            7   O6a O    24.0569  -16.9656
            8   O6a O    25.2483  -14.8631
            9   O6a O    30.1540  -16.2648
            10  O6a O    28.8925  -18.3673
            11  C1x C     9.4797  -15.4939
            12  C8y C     9.4797  -16.8955
            13  C8y C    10.6935  -17.5964
            14  C1y C    11.9074  -16.8955
            15  C1y C    11.9074  -15.4939
            16  C1x C    10.6935  -14.7930
            17  C8x C     8.2659  -17.5964
            18  C8y C     8.2659  -18.9980
            19  C8x C     9.4797  -19.6989
            20  C8x C    10.6935  -18.9980
            21  C8y C    13.1400  -14.7820
            22  C8y C    13.1400  -17.6074
            23  C8x C    14.3466  -15.4786
            24  C8x C    15.5604  -14.7776
            25  C8x C    15.5604  -13.3760
            26  C8x C    14.3537  -12.6794
            27  C8x C    13.1399  -13.3804
            28  C8x C    13.1397  -18.9979
            29  C8x C    14.3534  -19.6991
            30  C8y C    15.5675  -18.9985
            31  C8x C    15.5678  -17.6080
            32  C8x C    14.3540  -16.9068
            33  O2a O    16.7907  -19.6989
            34  C1b C    18.0047  -18.9980
            35  C1b C    19.2185  -19.6989
            36  N1y N    20.4356  -18.9987
            37  C1x C    21.7567  -19.4100
            38  C1x C    22.5560  -18.2808
            39  C1x C    21.7292  -17.1715
            40  C1x C    20.4186  -17.6152
            41  O1a O     7.0690  -19.6892
BOND        44
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 2
            8     5   9 1
            9     5  10 2
            10   11  12 1
            11   12  13 2
            12   13  14 1
            13   14  15 1
            14   15  16 1
            15   11  16 1
            16   12  17 1
            17   17  18 2
            18   18  19 1
            19   19  20 2
            20   20  13 1
            21   15  21 1 #Down
            22   14  22 1 #Down
            23   21  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   26  27 1
            28   21  27 2
            29   22  28 2
            30   28  29 1
            31   29  30 2
            32   30  31 1
            33   31  32 2
            34   22  32 1
            35   30  33 1
            36   33  34 1
            37   34  35 1
            38   35  36 1
            39   36  37 1
            40   37  38 1
            41   38  39 1
            42   39  40 1
            43   36  40 1
            44   18  41 1

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