KEGG   DRUG: Leridistim
Entry
D04695                      Drug                                   

Name
Leridistim (USAN/INN)
Formula
C1550H2463N425O462S12
Exact mass
34806.8949
Mol weight
34828.4915
Sequence
ANCSNMIDEI ITHLKQPPLP LLDFNNLNGE DQDILMDNNL RRPNLEAFNR AVKSLQNASA
IESILKNLLP CLPLATAAPT RHPIHIKDGD WNEFRRKLTF YLKTLENAQA QQYVEGGGGS
PGEPSGPIST INPSPPSKES HKSPNMATPL GPASSLPQSF LLKSLEQVRK IQGDGAALQE
KLCATYKLCH PEELVLLGHS LGIPWAPLSS CPSQALQLAG CLSQLHSGLF LYQGLLQALE
GISPELGPTL DTLQLDVADF ATTIWQQMEE LGMAPALQPT QGAMPAFASA FQRRAGGVLV
ASHLQSFLEV SYRVLRHLAQ P
  Type
Peptide
Class
Cardiovascular agent
 DG01753  Colony stimulating factor
Efficacy
Antineutropenic, Antithrombocytopenia
Comment
Treatment of chemotherapy-induced neutropenia and thrombocytopenia (multifunctional agonist that activates both interleukin-3 and G-CSF receptors)
Target
CSF3R (GCSFR, CD114) [HSA:1441] [KO:K05061]
IL3RA (CD123) [HSA:3563] [KO:K04737]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interleukin receptors
    IL3RA (CD123)
     D04695  Leridistim (USAN/INN)
   CSF and other factor receptors
    CSF3R (GCSFR, CD114)
     D04695  Leridistim (USAN/INN)
Other DBs
CAS: 193700-51-5
PubChem: 47206528
LinkDB

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